Search Results - "Newkirk, Simon J."

Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia by Gu, Zhimin, Liu, Yuxuan, Zhang, Yuannyu, Cao, Hui, Lyu, Junhua, Wang, Xun, Wylie, Annika, Newkirk, Simon J., Jones, Amanda E., Lee, Michael, Botten, Giovanni A., Deng, Mi, Dickerson, Kathryn E., Zhang, Cheng Cheng, An, Wenfeng, Abrams, John M., Xu, Jian

“…Transposable elements or transposons are major players in genetic variability and genome evolution. Aberrant activation of long interspersed element-1 (LINE-1…”
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Intact piRNA pathway prevents L1 mobilization in male meiosis by Newkirk, Simon J., Lee, Suman, Grandi, Fiorella C., Gaysinskaya, Valeriya, Rosser, James M., Vanden Berg, Nicole, Hogarth, Cathryn A., Marchetto, Maria C. N., Muotri, Alysson R., Griswold, Michael D., Ye, Ping, Bortvin, Alex, Gage, Fred H., Boeke, Jef D., An, Wenfeng

“…The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit…”
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Subfamily-specific quantification of endogenous mouse L1 retrotransposons by droplet digital PCR by Newkirk, Simon J., Kong, Lingqi, Jones, Mason M., Habben, Chase E., Dilts, Victoria L., Ye, Ping, An, Wenfeng

“…Long interspersed element type 1 (LINE-1; L1) mobilizes during early embryogenesis, neurogenesis, and germ cell development, accounting for 25% of…”
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Subfamily-specific differential contribution of individual monomers and the tether sequence to mouse L1 promoter activity by Kong, Lingqi, Saha, Karabi, Hu, Yuchi, Tschetter, Jada N, Habben, Chase E, Whitmore, Leanne S, Yao, Changfeng, Ge, Xijin, Ye, Ping, Newkirk, Simon J, An, Wenfeng

“…The internal promoter in L1 5'UTR is critical for autonomous L1 transcription and initiating retrotransposition. Unlike the human genome, which features one…”
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Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype by Wang, Zhuqing, McSwiggin, Hayden, Newkirk, Simon J, Wang, Yue, Oliver, Daniel, Tang, Chong, Lee, Sandy, Wang, Shawn, Yuan, Shuiqiao, Zheng, Huili, Ye, Ping, An, Wenfeng, Yan, Wei

“…Transposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns…”
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UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis by Newkirk, Simon J, An, Wenfeng

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Influenza D virus diverges from its related influenza C virus in the recognition of 9-O-acetylated N-acetyl- or N-glycolyl-neuraminic acid-containing glycan receptors by Liu, Runxia, Sreenivasan, Chithra, Yu, Hai, Sheng, Zizhang, Newkirk, Simon J., An, Wenfeng, Smith, David F., Chen, Xi, Wang, Dan, Li, Feng

“…Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to other mammalian hosts. By using traditional hemagglutination assay…”
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SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina by Vazquez, Berta N, Thackray, Joshua K, Simonet, Nicolas G, Chahar, Sanjay, Kane-Goldsmith, Noriko, Newkirk, Simon J, Lee, Suman, Xing, Jinchuan, Verzi, Michael P, An, Wenfeng, Vaquero, Alejandro, Tischfield, Jay A, Serrano, Lourdes

“…Abstract Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic…”
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Identification and characterization of viral defective RNA genomes in influenza B virus by Sheng, Zizhang, Liu, Runxia, Yu, Jieshi, Ran, Zhiguang, Newkirk, Simon J, An, Wenfeng, Li, Feng, Wang, Dan

“…Influenza B virus (FLUBV) is an important pathogen that infects humans and causes seasonal influenza epidemics. To date, little is known about defective…”
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Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites by Grandi, Fiorella C, Rosser, James M, Newkirk, Simon J, Yin, Jun, Jiang, Xiaoling, Xing, Zhuo, Whitmore, Leanne, Bashir, Sanum, Ivics, Zoltán, Izsvák, Zsuzsanna, Ye, Ping, Yu, Y Eugene, An, Wenfeng

“…Long interspersed elements (LINEs), through both self-mobilization and trans-mobilization of short interspersed elements and processed pseudogenes, have made…”
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Corrigendum: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites by Grandi, Fiorella C, Rosser, James M, Newkirk, Simon J, Yin, Jun, Jiang, Xiaoling, Xing, Zhuo, Whitmore, Leanne, Bashir, Sanum, Ivics, Zoltán, Izsvák, Zsuzsanna, Ye, Ping, Yu, Y Eugene, An, Wenfeng

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