Search Results - "Newham, Pete"

Stem cells, organoids and microphysiological systems coupled to modeling & simulation guide drug discovery and enhance translational safety risk assessment by Newham, Pete

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Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors by Baxter, Andrew, Brough, Steve, Cooper, Anne, Floettmann, Eike, Foster, Steve, Harding, Christine, Kettle, Jason, McInally, Tom, Martin, Craig, Mobbs, Michelle, Needham, Maurice, Newham, Pete, Paine, Stuart, St-Gallay, Steve, Salter, Sylvia, Unitt, John, Xue, Yafeng

“…A hit-to-lead optimisation programme was carried out on the thiophenecarboxamide high throughput screening hits 1 and 2 resulting in the discovery of the…”
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Modifying the risk-benefit ratio using drug delivery systems by Newham, Pete

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Proteolysis‐targeting chimeras in drug development: A safety perspective by Moreau, Kevin, Coen, Muireann, Zhang, Andrew X., Pachl, Fiona, Castaldi, M. Paola, Dahl, Goran, Boyd, Helen, Scott, Clay, Newham, Pete

“…Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a protein of interest for…”
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Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized by Hunter, David J, Gerstenfeld, Lou, Bishop, Gavin, Davis, A David, Mason, Zach D, Einhorn, Tom A, Maciewicz, Rose A, Newham, Pete, Foster, Martyn, Jackson, Sonya, Morgan, Elise F

“…Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the…”
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The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator by Grant, Claire, Ewart, Lorna, Muthas, Daniel, Deavall, Damian, Smith, Simon A., Clack, Glen, Newham, Pete

“…Nausea and vomiting are components of a complex mechanism that signals food avoidance and protection of the body against the absorption of ingested toxins…”
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Bromodomain and extraterminal (BET) domain inhibitors induce a loss of intestinal stem cells and villous atrophy by Wagoner, Matt, Kelsal, Janet, Hattersley, Maureen, Hickling, Kevin, Pederson, John, Harris, Jayne, Keirstead, Natalie, Heathcote, Dan, Newham, Pete

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