Search Results - "Newgard, C B"

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men by Tai, E. S, Tan, M. L. S, Stevens, R. D, Low, Y. L, Muehlbauer, M. J, Goh, D. L. M, Ilkayeva, O. R, Wenner, B. R, Bain, J. R, Lee, J. J. M, Lim, S. C, Khoo, C. M, Shah, S. H, Newgard, C. B

“…Aims/hypothesis Insulin resistance (IR) is associated with obesity, but can also develop in individuals with normal body weight. We employed comprehensive…”
Get full text

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss by Shah, S. H., Crosslin, D. R., Haynes, C. S., Nelson, S., Turer, C. B., Stevens, R. D., Muehlbauer, M. J., Wenner, B. R., Bain, J. R., Laferrère, B., Gorroochurn, P., Teixeira, J., Brantley, P. J., Stevens, V. J., Hollis, J. F., Appel, L. J., Lien, L. F., Batch, B., Newgard, C. B., Svetkey, L. P.

“…Aims/hypothesis Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would…”
Get full text

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion by Hohmeier, H E, Mulder, H, Chen, G, Henkel-Rieger, R, Prentki, M, Newgard, C B

“…Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. H E Hohmeier , H…”
Get full text

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia by O'DOHERTY, R. M, LEHMAN, D. L, TELEMAQUE-POTTS, S, NEWGARD, C. B

“…Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. R M O'Doherty , D L Lehman , S…”
Get full text

Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans by Morgan, P G, Higdon, R, Kolker, N, Bauman, A T, Ilkayeva, O, Newgard, C B, Kolker, E, Steele, L M, Sedensky, M M

“…Single-gene mutations that disrupt mitochondrial respiratory chain function in Caenorhabditis elegans change patterns of protein expression and metabolites…”
Get full text

STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells by Schnedl, W. J., Ferber, S., Johnson, J. H., Newgard, C. B.

“…STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. W J Schnedl , S Ferber , J H Johnson and C B Newgard Gifford Laboratories for…”
Get full text

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1 by NEWGARD, Christopher B, BRADY, Matthew J, O'DOHERTY, Robert M, SALTIEL, Alan R

“…Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. C B Newgard , M J Brady , R M O'Doherty and A R…”
Get full text

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell by Roduit, Raphaël, Morin, Johane, Massé, Frédéric, Segall, Laura, Roche, Enrique, Newgard, Christopher B., Assimacopoulos-Jeannet, Françoise, Prentki, Marc

“…To better understand the action of glucose on fatty acid metabolism in the β-cell and the link between chronically elevated glucose or fatty acids and β-cell…”
Get full text

Adenovirus-Mediated Leptin Expression Normalises Hypertension Associated with Diet-Induced Obesity by Zhang, W., Telemaque, S., Augustyniak, R. A., Anderson, P., Thomas, G. D., An, J., Wang, Z., Newgard, C. B., Victor, R. G.

“…In our previous study, moderate increases in plasma leptin levels achieved via administration of recombinant adenovirus containing the rat leptin cDNA were…”
Get full text

beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy by Koyama, K., Chen, G., Wang, M. Y., Lee, Y., Shimabukuro, M., Newgard, C. B., Unger, R. H.

“…beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. K Koyama , G Chen , M Y Wang , Y Lee , M Shimabukuro , C…”
Get full text

Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis by Antinozzi, P A, Segall, L, Prentki, M, McGarry, J D, Newgard, C B

“…The mechanism by which glucose stimulates insulin secretion from the pancreatic islets of Langerhans is incompletely understood. It has been suggested that…”
Get full text

Inflammatory mechanisms in diabetes: lessons from the β-cell by Hohmeier, H.E, Tran, V.V, Chen, G, Gasa, R, Newgard, C.B

“…Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to type I diabetes. This involves infiltration of T-cells and…”
Get full text

Cellular engineering and gene therapy strategies for insulin replacement in diabetes by Newgard, C. B.

“…Cellular engineering and gene therapy strategies for insulin replacement in diabetes. C B Newgard Gillford Laboratories for Diabetes Research, University of…”
Get full text

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism by GOMEZ-FOIX, A. M, COATS, W. S, BAQUE, S, ALAM, T, GERARD, R. D, NEWGARD, C. B

“…The muscle isozyme of glycogen phosphorylase is potently activated by the allosteric ligand AMP, whereas the liver isozyme is not. In this study we have…”
Get full text

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function by WANG, M.-Y, SHIMABUKURO, M, YOUNG LEE, TRINH, K. Y, CHEN, J.-L, NEWGARD, C. B, UNGER, R. H

“…Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell…”
Get full text

Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism by Teh, J T, Zhu, W L, Ilkayeva, O R, Li, Y, Gooding, J, Casey, P J, Summers, S A, Newgard, C B, Wang, M

“…Isoprenylcysteine carboxylmethyltransferase (Icmt) catalyzes the last of the three-step posttranslational protein prenylation process for the so-called CaaX…”
Get full text

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids by Milburn, Jr, J L, Hirose, H, Lee, Y H, Nagasawa, Y, Ogawa, A, Ohneda, M, BeltrandelRio, H, Newgard, C B, Johnson, J H, Unger, R H

“…To elucidate the mechanism of the basal hyperinsulinemia of obesity, we perfused pancreata from obese Zucker and lean Wistar rats with substimulatory…”
Get full text

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels by Becker, T.C, BeltrandelRio, H, Noel, R.J, Johnson, J.H, Newgard, C.B

“…Glucose metabolism and glucose-stimulated insulin secretion are thought to be controlled at the level of glucose phosphorylation in pancreatic islet…”
Get full text

Regulation of insulin secretion from novel engineered insulinoma cell lines by H E Hohmeier, H BeltrandelRio, S A Clark, R Henkel-Rieger, K Normington, C B Newgard

“…Regulation of insulin secretion from novel engineered insulinoma cell lines. H E Hohmeier , H BeltrandelRio , S A Clark , R Henkel-Rieger , K Normington and C…”
Get full text

Protein synthesis. The perks of balancing glucose by Sonenberg, N, Newgard, C B

“…What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard…”
Get full text