Search Results - "Newgard, C"

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men by Tai, E. S, Tan, M. L. S, Stevens, R. D, Low, Y. L, Muehlbauer, M. J, Goh, D. L. M, Ilkayeva, O. R, Wenner, B. R, Bain, J. R, Lee, J. J. M, Lim, S. C, Khoo, C. M, Shah, S. H, Newgard, C. B

“…Aims/hypothesis Insulin resistance (IR) is associated with obesity, but can also develop in individuals with normal body weight. We employed comprehensive…”
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Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss by Shah, S. H., Crosslin, D. R., Haynes, C. S., Nelson, S., Turer, C. B., Stevens, R. D., Muehlbauer, M. J., Wenner, B. R., Bain, J. R., Laferrère, B., Gorroochurn, P., Teixeira, J., Brantley, P. J., Stevens, V. J., Hollis, J. F., Appel, L. J., Lien, L. F., Batch, B., Newgard, C. B., Svetkey, L. P.

“…Aims/hypothesis Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would…”
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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion by Hohmeier, H E, Mulder, H, Chen, G, Henkel-Rieger, R, Prentki, M, Newgard, C B

“…Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. H E Hohmeier , H…”
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Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism by Teh, J T, Zhu, W L, Ilkayeva, O R, Li, Y, Gooding, J, Casey, P J, Summers, S A, Newgard, C B, Wang, M

“…Isoprenylcysteine carboxylmethyltransferase (Icmt) catalyzes the last of the three-step posttranslational protein prenylation process for the so-called CaaX…”
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Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans by Morgan, P G, Higdon, R, Kolker, N, Bauman, A T, Ilkayeva, O, Newgard, C B, Kolker, E, Steele, L M, Sedensky, M M

“…Single-gene mutations that disrupt mitochondrial respiratory chain function in Caenorhabditis elegans change patterns of protein expression and metabolites…”
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Metabolomics in the developmental origins of obesity and its cardiometabolic consequences by Hivert, M F, Perng, W, Watkins, S M, Newgard, C S, Kenny, L C, Kristal, B S, Patti, M E, Isganaitis, E, DeMeo, D L, Oken, E, Gillman, M W

“…In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD)…”
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Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia by O'DOHERTY, R. M, LEHMAN, D. L, TELEMAQUE-POTTS, S, NEWGARD, C. B

“…Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. R M O'Doherty , D L Lehman , S…”
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Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell by Roduit, Raphaël, Morin, Johane, Massé, Frédéric, Segall, Laura, Roche, Enrique, Newgard, Christopher B., Assimacopoulos-Jeannet, Françoise, Prentki, Marc

“…To better understand the action of glucose on fatty acid metabolism in the β-cell and the link between chronically elevated glucose or fatty acids and β-cell…”
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Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells by St-Pierre, Julie, Lin, Jiandie, Krauss, Stefan, Tarr, Paul T., Yang, Ruojing, Newgard, Christopher B., Spiegelman, Bruce M.

“…Peroxisome proliferator-activated receptor γ coactivator (PGC)-1α is a coactivator of nuclear receptors and other transcription factors that regulates several…”
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Molecular predictors of hand strength by Thompson, D, Huffman, K, McDaniel, G, Bain, J, Stevens, R, Newgard, C, Kraus, V

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Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1 by NEWGARD, Christopher B, BRADY, Matthew J, O'DOHERTY, Robert M, SALTIEL, Alan R

“…Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. C B Newgard , M J Brady , R M O'Doherty and A R…”
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 by Spiegelman, Bruce M, Yoon, J. Cliff, Puigserver, Pere, Chen, Guoxun, Donovan, Jerry, Wu, Zhidan, Rhee, James, Adelmant, Guillaume, Stafford, John, Kahn, C. Ronald, Granner, Daryl K, Newgard, Christopher B

“…Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly…”
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STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells by Schnedl, W. J., Ferber, S., Johnson, J. H., Newgard, C. B.

“…STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. W J Schnedl , S Ferber , J H Johnson and C B Newgard Gifford Laboratories for…”
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Defining the “older” crash victim: The relationship between age and serious injury in motor vehicle crashes by Newgard, Craig D.

“…Age is often used as a predictor of injury and mortality in motor vehicle crashes (MVCs), however, the age that defines an “older” occupant in terms of…”
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Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis by Antinozzi, P A, Segall, L, Prentki, M, McGarry, J D, Newgard, C B

“…The mechanism by which glucose stimulates insulin secretion from the pancreatic islets of Langerhans is incompletely understood. It has been suggested that…”
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Inflammatory mechanisms in diabetes: lessons from the β-cell by Hohmeier, H.E, Tran, V.V, Chen, G, Gasa, R, Newgard, C.B

“…Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to type I diabetes. This involves infiltration of T-cells and…”
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Adenovirus-Mediated Leptin Expression Normalises Hypertension Associated with Diet-Induced Obesity by Zhang, W., Telemaque, S., Augustyniak, R. A., Anderson, P., Thomas, G. D., An, J., Wang, Z., Newgard, C. B., Victor, R. G.

“…In our previous study, moderate increases in plasma leptin levels achieved via administration of recombinant adenovirus containing the rat leptin cDNA were…”
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PGC-1β in the Regulation of Hepatic Glucose and Energy Metabolism by Lin, Jiandie, Tarr, Paul T., Yang, Ruojing, Rhee, James, Puigserver, Pere, Newgard, Christopher B., Spiegelman, Bruce M.

“…Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional coactivator that regulates multiple aspects of cellular energy…”
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Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids by Milburn, Jr, J L, Hirose, H, Lee, Y H, Nagasawa, Y, Ogawa, A, Ohneda, M, BeltrandelRio, H, Newgard, C B, Johnson, J H, Unger, R H

“…To elucidate the mechanism of the basal hyperinsulinemia of obesity, we perfused pancreata from obese Zucker and lean Wistar rats with substimulatory…”
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beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy by Koyama, K., Chen, G., Wang, M. Y., Lee, Y., Shimabukuro, M., Newgard, C. B., Unger, R. H.

“…beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. K Koyama , G Chen , M Y Wang , Y Lee , M Shimabukuro , C…”
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