Search Results - "Newell, Kelly A."

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice by Liu, Yi, Zhang, Yuyun, Zheng, Xian, Fang, Tongyong, Yang, Xia, Luo, Xuan, Guo, Anlei, Newell, Kelly A, Huang, Xu-Feng, Yu, Yinghua

“…Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer's disease. Lipopolysaccharide (LPS,…”
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Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia by MATOSIN, Natalie, NEWELL, Kelly A

“…Metabotropic glutamate receptor 5 (mGluR5) potentiates the NMDA receptor (NMDAR) in brain regions implicated in schizophrenia, making it a viable therapeutic…”
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Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture by Matosin, Natalie, Frank, Elisabeth, Engel, Martin, Lum, Jeremy S, Newell, Kelly A

“…Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is…”
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Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment by Lum, Jeremy S., Bird, Katrina M., Wilkie, Jennifer, Millard, Samuel J., Pallimulla, Sachie, Newell, Kelly A., Wright, Ian M.

“…Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide. Despite its widespread use, MMT is associated…”
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Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia by Andrews, Jessica L., Zalesky, Andrew, Nair, Shalima, Sullivan, Ryan P., Green, Melissa J., Pantelis, Christos, Newell, Kelly A., Fernandez, Francesca

“…Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) plays a vital role in a large number of neuronal processes underlying learning and…”
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Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients by Phillips, Gabrielle R., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., Kreilaus, Fabian, Newell, Kelly A., Mitchell, Todd W.

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt),…”
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Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics by Matosin, Natalie, BMSc Hons, Fernandez-Enright, Francesca, PhD, Frank, Elisabeth, PhD, Deng, Chao, PhD, Wong, Jenny, PhD, Huang, Xu-Feng, MD, PhD, Newell, Kelly A., PhD

“…Background Metabotropic glutamate receptors 2/3 (mGluR2/3) and 5 (mGluR5) are novel therapeutic targets for major depression (MD), bipolar disorder (BD) and…”
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Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway by Liu, Yi, Huang, Jie, Zheng, Xian, Yang, Xia, Ding, Yan, Fang, Tongyong, Zhang, Yuyun, Wang, Shuaishuai, Zhang, Xiaofei, Luo, Xuan, Guo, Anlei, Newell, Kelly A., Yu, Yinghua, Huang, Xu-Feng

“…Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has…”
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Phospholipid Profiles Are Selectively Altered in the Putamen and White Frontal Cortex of Huntington's Disease by Phillips, Gabrielle R, Hancock, Sarah E, Jenner, Andrew M, McLean, Catriona, Newell, Kelly A, Mitchell, Todd W

“…Huntington's disease (HD) is a genetic, neurodegenerative illness that onsets in late adulthood as a series of progressive and terminal cognitive, motor, and…”
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Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression by Han, Mei, Deng, Chao, Burne, Thomas H.J, Newell, Kelly A, Huang, Xu-Feng

“…Summary The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats…”
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The long and the short of Huntington’s disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases by Phillips, Gabrielle R., Saville, Jennifer T., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., McLean, Catriona, Fuller, Maria, Newell, Kelly A., Mitchell, Todd W.

“…Abstract Huntington’s disease is a devastating neurodegenerative disorder that onsets in late adulthood as progressive and terminal cognitive, psychiatric and…”
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The kynurenine pathway in major depression: What we know and where to next by Brown, Samara J., Huang, Xu-Feng, Newell, Kelly A.

“…•A growing body of evidence suggests the kynurenine pathway contributes to the pathophysiology of depression.•In this review, we integrate the clinical and…”
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Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats by Andrews, Jessica L., Newell, Kelly A., Matosin, Natalie, Huang, Xu-Feng, Fernandez, Francesca

“…Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood…”
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The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences by Millard, Samuel J., Weston-Green, Katrina, Newell, Kelly A.

“…Major depressive disorder (MDD) is one of the leading causes of years lived with disability and contributor to the burden of disease worldwide. The incidence…”
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The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders by Millard, Samuel J., Weston-Green, Katrina, Newell, Kelly A.

“…[Display omitted] •10% of pregnant women are prescribed Selective Serotonin Reuptake Inhibitors.•Serotonin is critical to brain development and behaviour.•SSRI…”
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Exercise and yoga during pregnancy and their impact on depression: a systematic literature review by Jarbou, Noor S., Newell, Kelly A.

“…  It is well established that exercise can improve depressive symptoms in the general population; however, it is not clear if these benefits are also seen in…”
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Sex- and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression by Brown, Samara J, Christofides, Katerina, Weissleder, Christin, Huang, Xu-Feng, Shannon Weickert, Cynthia, Lim, Chai K, Newell, Kelly A

“…Major depressive disorder (MDD) is a serious psychiatric disorder that in extreme cases can lead to suicide. Evidence suggests that alterations in the…”
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Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia by Osborne, Ashleigh L., Solowij, Nadia, Babic, Ilijana, Lum, Jeremy S., Newell, Kelly A., Huang, Xu-Feng, Weston-Green, Katrina

“…The mainstay treatment for schizophrenia is antipsychotic drugs (APDs), which are mostly effective against the positive symptoms (e.g. hallucinations), but…”
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Shifting towards a model of mGluR5 dysregulation in schizophrenia: Consequences for future schizophrenia treatment by Matosin, Natalie, Fernandez-Enright, Francesca, Lum, Jeremy S., Newell, Kelly A.

“…Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene, represents a compelling novel drug target for the treatment of schizophrenia…”
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N-Methyl-d-Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia by Rahman, Tasnim, Purves-Tyson, Tertia, Geddes, Amy E., Huang, Xu-Feng, Newell, Kelly A., Weickert, Cynthia Shannon

“…Lower N-methyl-d-aspartate receptor (NMDAR) GluN1 subunit levels and heightened neuroinflammation are found in the cortex in schizophrenia. Since…”
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