Search Results - "Newell, Karen"

Cytoskeletal regulation of synaptogenesis in a model of human fetal brain development by Wilson, Emily, Rudisill, Taylor, Kirk, Brenna, Johnson, Colin, Kemper, Paige, Newell‐Litwa, Karen

“…Excitatory synapse formation begins in mid‐fetal gestation. However, due to our inability to image fetal synaptogenesis, the initial formation of synapses…”
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Non-muscle myosin II in disease: mechanisms and therapeutic opportunities by Newell-Litwa, Karen A, Horwitz, Rick, Lamers, Marcelo L

“…The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell morphology, with a role in several essential cellular processes,…”
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ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity by Newell-Litwa, Karen A, Badoual, Mathilde, Asmussen, Hannelore, Patel, Heather, Whitmore, Leanna, Horwitz, Alan Rick

“…RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in…”
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TGR5 signaling reduces neuroinflammation during hepatic encephalopathy by McMillin, Matthew, Frampton, Gabriel, Tobin, Richard, Dusio, Giuseppina, Smith, Jenny, Shin, Hope, Newell‐Rogers, Karen, Grant, Stephanie, DeMorrow, Sharon

“…Hepatic encephalopathy (HE) is a serious neurological complication of acute and chronic liver failure. Expression of the neurosteroid/bile acid receptor Takeda…”
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The effects of inflammatory cytokines on lymphatic endothelial barrier function by Cromer, Walter E., Zawieja, Scott D., Tharakan, Binu, Childs, Ed W., Newell, M. Karen, Zawieja, David C.

“…Proper lymphatic function is necessary for the transport of fluids, macromolecules, antigens and immune cells out of the interstitium. The lymphatic…”
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Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis by Divan, Ali, Casselli, Timothy, Narayanan, S Anand, Mukherjee, Sanjib, Zawieja, David C, Watt, John A, Brissette, Catherine A, Newell-Rogers, M Karen

“…Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If…”
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The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition by Peddaboina, Chander, Jupiter, Daniel, Fletcher, Steven, Yap, Jeremy L, Rai, Arun, Tobin, Richard P, Jiang, Weihua, Rascoe, Philip, Rogers, M Karen Newell, Smythe, W Roy, Cao, Xiaobo

“…It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of…”
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Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to a Traumatic Brain Injury by Newell-Rogers, M Karen, Duong, Amanda, Nazarali, Rizwan, Tobin, Richard P, Rogers, Susannah K, Shapiro, Lee A

“…TBI induces splenic B and T cell expansion that contributes to neuroinflammation and neurodegeneration. The vagus nerve, the longest of the cranial nerves, is…”
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Antagonism of Macrophage Migration Inhibitory Factory (MIF) after Traumatic Brain Injury Ameliorates Astrocytosis and Peripheral Lymphocyte Activation and Expansion by Newell-Rogers, M Karen, Rogers, Susannah K, Tobin, Richard P, Mukherjee, Sanjib, Shapiro, Lee A

“…Traumatic brain injury (TBI) precedes the onset of epilepsy in up to 15-20% of symptomatic epilepsies and up to 5% of all epilepsy. Treatment of acquired…”
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Neuronal and non-neuronal functions of the AP-3 sorting machinery by Newell-Litwa, Karen, Seong, Eunju, Burmeister, Margit, Faundez, Victor

“…Vesicles selectively exchange lipids, membrane proteins and luminal contents between organelles along the exocytic and endocytic routes. The repertoire of…”
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Stem cell models of human synapse development and degeneration by Wilson, Emily S, Newell-Litwa, Karen

“…Many brain disorders exhibit altered synapse formation in development or synapse loss with age. To understand the complexities of human synapse development and…”
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Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice by Iannucci, Jaclyn, Dominy, Reagan, Bandopadhyay, Shreya, Arthur, E Madison, Noarbe, Brenda, Jullienne, Amandine, Krkasharyan, Margret, Tobin, Richard P, Pereverzev, Aleksandr, Beevers, Samantha, Venkatasamy, Lavanya, Souza, Karienn A, Jupiter, Daniel C, Dabney, Alan, Obenaus, Andre, Newell-Rogers, M Karen, Shapiro, Lee A

“…Traumatic brain injury (TBI) is a significant risk factor for Alzheimer's disease (AD), and accumulating evidence supports a role for adaptive immune B and T…”
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Depletion of MHC class II invariant chain peptide or γ-δ T-cells ameliorates experimental preeclampsia by Chatterjee, Piyali, Chiasson, Valorie L, Seerangan, Geetha, De Guzman, Eugene, Milad, Moheb, Bounds, Kelsey R, Gasheva, Olga, Tobin, Richard P, Hatahet, Mohamad, Kopriva, Shelley, Jones, Kathleen A, Newell-Rogers, M Karen, Mitchell, Brett M

“…Excessive innate immune system activation and inflammation during pregnancy can lead to organ injury and dysfunction and preeclampsia (PE); however, the…”
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γδ T Cells and dendritic cells in refractory Lyme arthritis by Divan, Ali, Budd, Ralph C., Tobin, Richard P., Newell‐Rogers, M. Karen

“…Review on TLR signaling and antigen processing, presentation between γδ T cells and dendritic cells, both which contribute to refractory Lyme arthritis. Lyme…”
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Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration by Tobin, Richard P, Mukherjee, Sanjib, Kain, Jessica M, Rogers, Susannah K, Henderson, Stephanie K, Motal, Heather L, Newell Rogers, M Karen, Shapiro, Lee A

“…Traumatic brain injury (TBI), a significant cause of death and disability, causes, as in any injury, an acute, innate immune response. A key component in the…”
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Cell Migration: PKA and RhoA Set the Pace by Newell-Litwa, Karen A., Horwitz, Alan Rick

“…A new study shows that protein kinase A (PKA) activity establishes a signaling loop that governs protrusion–retraction cycles in migrating cells. PKA activity…”
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Differential Effects of In Vitro Treatment with Cinobufotalin on Three Types of Ovarian Cancer Cells by Afroze, Syeda H, Peddaboina, Chander, McDowell, Jr, Anthony B, Ashraf, A H M Zuberi, McCormick, Timothy C, Newell-Rogers, M Karen, Zawieja, David C, Kuehl, Thomas J, Uddin, Mohammad N

“…Cinobufotalin (CINO), a cardiotonic steroid, has been used as an anticancer agent. This study assessed the cell-specific effect of CINO on SK-OV-3, CRL-1978…”
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Racial Disparities in Malignant Primary Brain Tumor Survival in Texas From 1995 to 2013 by Ambe, Solomon, Lyon, Kristopher A, Oh, Janice, Rogers, M Karen Newell, Olanipekun, Olalekan, Basil, Nduma N, Fonkem, Ekokobe

“…Differences among the top five races in Texas will be explored to determine if racial, geographic, and healthcare disparities exist in patients undergoing…”
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Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells by Vicente-Manzanares, Miguel, Newell-Litwa, Karen, Bachir, Alexia I, Whitmore, Leanna A, Horwitz, Alan Rick

“…Migratory front-back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during…”
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RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development by Martin-Vilchez, Samuel, Whitmore, Leanna, Asmussen, Hannelore, Zareno, Jessica, Horwitz, Rick, Newell-Litwa, Karen

“…Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic…”
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