Search Results - "Newcomer, M. E"

Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices by Deochand, D K, Perera, I C, Crochet, R B, Gilbert, N C, Newcomer, M E, Grove, A

“…Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological…”
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The structure of β -lactoglobulin and its similarity to plasma retinol-binding protein by Papiz, M. Z, Sawyer, L, Eliopoulos, E. E, North, A. C. T, Findlay, J. B. C, Sivaprasadarao, R, Jones, T. A, Newcomer, M. E, Kraulis, P. J

“…Since its first isolation, bovine beta-lactoglobulin (BLG) has been an enigma: although it is abundant in the whey fraction of milk, its function is still not…”
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Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol by Cowan, S W, Newcomer, M E, Jones, T A

“…P2 myelin protein (P2) and cellular retinol binding protein (CRBP) are members of a family of cellular lipophilic transport proteins. P2 has been refined at a…”
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Effect of pH and salt bridges on structural assembly: Molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain by Kishan, K.V. Radha, Newcomer, Marcia E., Rhodes, Thomas H., Guilliot, Stephen D.

“…The SH3 domain of Eps8 was previously found to form an intertwined, domain‐swapped dimer. We report here a monomeric structure of the EPS8 SH3 domain obtained…”
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Crystallographic refinement of human serum retinol binding protein at 2A resolution by Cowan, S W, Newcomer, M E, Jones, T A

“…Human serum retinol binding protein (RBP) in complex with retinol has been crystallographically refined to an R-factor of 18.1% with 2A resolution data. The…”
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Crystal structure of apo‐glycine N‐methyltransferase (GNMT) by Pattanayek, R., Newcomer, M.E., Wagner, C.

“…The crystal structure of the recombinant apo‐form of glycine N‐methyltransferase (GNMT) has been determined at 2.5 Å resolution. GNMT is a tetrameric enzyme…”
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Endogenous retinoids in rat epididymal tissue and rat and human spermatozoa by PAPPAS, R. S, NEWCOMER, M. E, ONG, D. E

“…Recent work has demonstrated high levels of retinoid binding proteins in rat epididymis, and a lumenal retinoic acid binding protein has been purified. These…”
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three-dimensional structure of retinol-binding protein by Newcomer, M.E, Jones, T.A, Aqvist, J, Sundelin, J, Eriksson, U, Rask, L, Peterson, P.A

“…The complex of retinol with its carrier protein, retinol‐binding protein (RBP) has been crystallized and its three‐dimensional structure determined using X‐ray…”
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Protein and ligand adaptation in a retinoic acid binding protein by PATTANAYEK, REKHA, NEWCOMER, MARCIA E.

“…A retinoic acid binding protein isolated from the lumen of the rat epididymis (ERABP) is a member of the lipocalin superfamily. ERABP binds both the all-trans…”
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X-Ray Crystallographic Identification of a Protein-Binding Site for Both All-Trans- and 9-cis-Retinoic Acid by NEWCOMER, M. E, PAPPAS, R. S, ONG, D. E

“…The elucidation of how a protein-binding site might specifically recognize both the all-trans and 9-cis isomers of retinoic acid is of particular interest…”
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Purification and crystallization of a retinoic acid-binding protein from rat epididymis. Identity with the major androgen-dependent epididymal proteins by NEWCOMER, M. E, ONG, D. E

“…The retinoic acid binding activity in the lumen of the rat epididymis (Ong, D., and Chytil, F. (1988) Arch. Biochem. Biophys. 267, 474-478) has been purified…”
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The Structure of Human Retinol-Binding Protein (RBP) with Its Carrier Protein Transthyretin Reveals an Interaction with the Carboxy Terminus of RBP by Naylor, Helen M, Newcomer, Marcia E

“…Whether ultimately utilized as retinoic acid, retinal, or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding…”
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Cellular Retinoid-Binding Proteins: Limited Proteolysis Reveals a Conformational Change upon Ligand Binding by Jamison, Robert S, Newcomer, Marcia E, Ong, David E

“…Intracellular retinoid-binding proteins are small, tightly folded, compact proteins, which appear to be involved in the delivery of retinoids to microsomal…”
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Purification of Receptor Protein Trg by Exploiting a Property Common to Chemotactic Transducers of Escherichia coli by Burrows, G G, Newcomer, M E, Hazelbauer, G L

“…The methyl-accepting chemotactic transducers of Escherichia coli were found to bind strongly to Cibacron blue-Sepharose. Among potential elutants tested, only…”
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Retinoid-binding proteins: structural determinants important for function by Newcomer, M E

“…The transport and functions of biologically active naturally occurring retinoids (Vitamin A, retinol, and its metabolites) are mediated by extracellular,…”
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The radius of gyration of L-arabinose-binding protein decreases upon binding of ligand by Newcomer, M E, Lewis, B A, Quiocho, F A

“…The technique of small angle x-ray scattering has been employed to study the effect of sugars on the radius of gyration of the L-arabinose-binding protein, a…”
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Molecular dynamics simulations of the holo and apo forms of retinol binding protein. Structural and dynamical changes induced by retinol removal by Aqvist, J, Sandblom, P, Jones, T A, Newcomer, M E, van Gunsteren, W F, Tapia, O

“…The effects of removing retinol from the X-ray structure of holo-retinol binding protein are studied using the molecular dynamics technique. Structural and…”
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Crystallization of and preliminary X-ray data for the plasma retinol-binding protein by Newcomer, M E, Liljas, A, Sundelin, J, Rask, L, Peterson, P A

“…Crystals of the human and rabbit plasma retinol-binding proteins have been grown from solutions of polyethylene glycol 6000 and CdCl2. Two crystal forms have…”
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A helical lid converts a sulfotransferase to a dehydratase by Newcomer, Marcia E, Pakhomova, Svetlana, Kobayashi, Mime, Buck, Jochen

“…We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the…”
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Plasma retinol binding protein: structure and function of the prototypic lipocalin by Newcomer, Marcia E, Ong, David E

“…In terms of both structure and biological function, retinol binding protein (RBP) is one of the best characterized members of the lipocalin superfamily. The…”
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