Search Results - "Newcomb, John R"

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors by Zhu, Xiaotian, Kim, Joseph L, Newcomb, John R, Rose, Paul E, Stover, David R, Toledo, Leticia M, Zhao, Huilin, Morgenstern, Kurt A

“…Background: The lymphocyte-specific kinase Lck is a member of the Src family of non-receptor tyrosine kinases. Lck catalyzes the initial phosphorylation of…”
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Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors by Buchanan, John L., Newcomb, John R., Carney, David P., Chaffee, Stuart C., Chai, Lilly, Cupples, Rod, Epstein, Linda F., Gallant, Paul, Gu, Yan, Harmange, Jean-Christophe, Hodge, Kathy, Houk, Brett E., Huang, Xin, Jona, Janan, Joseph, Smriti, Jun, H. Toni, Kumar, Rakesh, Li, Chun, Lu, John, Menges, Tom, Morrison, Michael J., Novak, Perry M., van der Plas, Simon, Radinsky, Robert, Rose, Paul E., Sawant, Satin, Sun, Ji-Rong, Surapaneni, Sekhar, Turci, Susan M., Xu, Keyang, Yanez, Evelyn, Zhao, Huilin, Zhu, Xiaotian

“…The discovery of 2,4-bis-arylamino-1,3-pyrimidines as IGF-1R inhibitors is described. Optimization studies led to the identification of 26, which displayed…”
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HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides by Riberdy, Janice M, Newcomb, John R, Surman, Michael J, Barbosat, James A, Cresswell, Peter

“…The invariant chain, which associates with the major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum, serves two functions…”
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N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR by Deak, Holly L., Newcomb, John R., Nunes, Joseph J., Boucher, Christina, Cheng, Alan C., DiMauro, Erin F., Epstein, Linda F., Gallant, Paul, Hodous, Brian L., Huang, Xin, Lee, Josie H., Patel, Vinod F., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian

“…A novel class of selective Lck inhibitors is reported. X-ray co-crystal structural data, structure–activity relationships, and the synthesis of these…”
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Mutations in Chlamydomonas reinhardtii conferring resistance to the herbicide sulfometuron methyl by Harnett, M.E, Newcomb, J.R, Hodson, R.C

“…Chlamydomonas reinhardtii mutants resistant to the herbicide sulfometuron methyl (SM) were isolated and characterized. Growth of C. reinhardtii is sensitive to…”
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Abstract 3609: Chimeric cytokine receptors increase memory phenotypes and improve expansion and efficacy of CAR-T cell therapies by Newcomb, John R., Ren, Jun, Syed, Sakeena, Caruolo, Zachary, Webb, Lindsay, McKay, Craig, Kwei, Stephanie, Novina, Carl, Mermelstein, Fred

“…Abstract Cytokine activation of T cells can promote T cell proliferation, memory and improve T cell function in driving tumor cell killing. However, systemic…”
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Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated αβ dimers by NEWCOMB, J. R, CRESSWELL, P

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Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers by Newcomb, John R., Carboy-Newcomb, Cerinda, Cresswell, Peter

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Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers by John R. Newcomb, Cerinda Carboy-Newcomb, Peter Cresswell

“…The invariant chain (I chain) associates with major histocompatibility complex class II αβ heterodimers upon synthesis, preventing them from binding peptides…”
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Affinity and kinetics of the interactions between an αβ T-cell receptor and its superantigen and class II-MHC/peptide ligands by Khandekar, Sanjay S., Brauer, Pamela P., Naylor, Jerome W., Chang, Hsiu-Ching, Kern, Petra, Newcomb, John R., Leclair, Kenneth P., Stump, Holly S., Bettencourt, Brian M., Kawasaki, Ernest, Banerji, Julian, Profy, Albert T., Jones, Barry

“…Immune activation is mediated by a specific interaction between the T-cell receptor (TCR) and an antigenic peptide bound to the major histocompatibility…”
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Studies on the immunosuppressive nature of staphylococcal enterotoxin B by Newcomb, John R

“…Staphylococcal enterotoxin B (SEB) is a potent activator of T cells. In order to activate T cells, SEB must first bind to major histocompatibility (MHC) class…”
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Mutations in Chlamydomonas reinhardtii Conferring Resistance to the Herbicide Sulfometuron Methyl 1 by Hartnett, Mary E., Newcomb, John R., Hodson, Robert C.

“…Chlamydomonas reinhardtii mutants resistant to the herbicide sulfometuron methyl (SM) were isolated and characterized. Growth of C. reinhardtii is sensitive to…”
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Effect of isotypic and allotypic variations of MHC class II molecules on staphylococcal enterotoxin presentation to murine T cells by Taub, D D, Newcomb, J R, Rogers, T J

“…Staphylococcal enterotoxins (SE) are known to be potent T cell activators, stimulating +/- proliferation and lymphokine production. These toxins have recently…”
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Requirement for accessory cells in suppression of MOPC-315 IgA secretion by staphylococcal enterotoxin B-induced T-suppressor cells by Newcomb, J R, Lin, Y S, Rogers, T J

“…Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T…”
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