Search Results - "Nevin, Zachary"

Induction of myelinating oligodendrocytes in human cortical spheroids by Madhavan, Mayur, Nevin, Zachary S., Shick, H. Elizabeth, Garrison, Eric, Clarkson-Paredes, Cheryl, Karl, Molly, Clayton, Benjamin L. L., Factor, Daniel C., Allan, Kevin C., Barbar, Lilianne, Jain, Tanya, Douvaras, Panagiotis, Fossati, Valentina, Miller, Robert H., Tesar, Paul J.

“…Cerebral organoids provide an accessible system for investigations of cellular composition, interactions, and organization but have lacked oligodendrocytes,…”
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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination by Hubler, Zita, Allimuthu, Dharmaraja, Bederman, Ilya, Elitt, Matthew S., Madhavan, Mayur, Allan, Kevin C., Shick, H. Elizabeth, Garrison, Eric, T. Karl, Molly, Factor, Daniel C., Nevin, Zachary S., Sax, Joel L., Thompson, Matthew A., Fedorov, Yuriy, Jin, Jing, Wilson, William K., Giera, Martin, Bracher, Franz, Miller, Robert H., Tesar, Paul J., Adams, Drew J.

“…Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem cell population in the central nervous system (CNS) and the principal…”
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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo by Najm, Fadi J., Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T., Factor, Daniel C., Miller, Tyler E., Nevin, Zachary S., Kantor, Christopher, Sargent, Alex, Quick, Kevin L., Schlatzer, Daniela M., Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R., Shen, Min, Boxer, Matthew B., Jadhav, Ajit, Robinson, Andrew P., Podojil, Joseph R., Miller, Stephen D., Miller, Robert H., Tesar, Paul J.

“…Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and…”
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Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease by Elitt, Matthew S., Barbar, Lilianne, Shick, H. Elizabeth, Powers, Berit E., Maeno-Hikichi, Yuka, Madhavan, Mayur, Allan, Kevin C., Nawash, Baraa S., Gevorgyan, Artur S., Hung, Stevephen, Nevin, Zachary S., Olsen, Hannah E., Hitomi, Midori, Schlatzer, Daniela M., Zhao, Hien T., Swayze, Adam, LePage, David F., Jiang, Weihong, Conlon, Ronald A., Rigo, Frank, Tesar, Paul J.

“…Mutations in PLP1 , the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked…”
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Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes by Nevin, Zachary S., Factor, Daniel C., Karl, Robert T., Douvaras, Panagiotis, Laukka, Jeremy, Windrem, Martha S., Goldman, Steven A., Fossati, Valentina, Hobson, Grace M., Tesar, Paul J.

“…Pelizaeus-Merzbacher disease (PMD) is a pediatric disease of myelin in the central nervous system and manifests with a wide spectrum of clinical severities…”
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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS by Factor, Daniel C., Barbeau, Anna M., Allan, Kevin C., Hu, Lucille R., Madhavan, Mayur, Hoang, An T., Hazel, Kathryn E.A., Hall, Parker A., Nisraiyya, Sagar, Najm, Fadi J., Miller, Tyler E., Nevin, Zachary S., Karl, Robert T., Lima, Bruna R., Song, Yanwei, Sibert, Alexandra G., Dhillon, Gursimran K., Volsko, Christina, Bartels, Cynthia F., Adams, Drew J., Dutta, Ranjan, Gallagher, Michael D., Phu, William, Kozlenkov, Alexey, Dracheva, Stella, Scacheri, Peter C., Tesar, Paul J., Corradin, Olivia

“…Multiple sclerosis (MS) is an autoimmune disease characterized by attack on oligodendrocytes within the central nervous system (CNS). Despite widespread use of…”
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Advances and challenges in modeling inherited peripheral neuropathies using iPSCs by Van Lent, Jonas, Prior, Robert, Pérez Siles, Gonzalo, Cutrupi, Anthony N., Kennerson, Marina L., Vangansewinkel, Tim, Wolfs, Esther, Mukherjee-Clavin, Bipasha, Nevin, Zachary, Judge, Luke, Conklin, Bruce, Tyynismaa, Henna, Clark, Alex J., Bennett, David L., Van Den Bosch, Ludo, Saporta, Mario, Timmerman, Vincent

“…Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations in various genes with fundamental roles in the development and…”
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Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease by Elitt, Matthew S., Shick, H. Elizabeth, Madhavan, Mayur, Allan, Kevin C., Clayton, Benjamin L.L., Weng, Chen, Miller, Tyler E., Factor, Daniel C., Barbar, Lilianne, Nawash, Baraa S., Nevin, Zachary S., Lager, Angela M., Li, Yan, Jin, Fulai, Adams, Drew J., Tesar, Paul J.

“…Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying…”
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A reference human induced pluripotent stem cell line for collaborative studies by Pantazis, CB, Yang, A, Lara, E, McDonough, JA, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D

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Modeling Genetic Diseases of Myelin Using Patient-derived Induced Pluripotent Stem Cells by Nevin, Zachary Scott

“…Myelin is a lipid-rich membrane that wraps, insulates, and provides trophic support to neural axons. Myelin is an essential component of the vertebrate central…”
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