Search Results - "Nevill, C. Richard"

Strategies for the Synthesis of Fusicoccanes by Nazarov Reactions of Dolabelladienones: Total Synthesis of (+)-Fusicoauritone by Williams, David R., Robinson, Leslie A., Nevill, C. Richard, Reddy, Jayachandra P.

“…Attaining closure: A synthetic pathway leading to (+)‐fusicoauritone (1) is highlighted by the use of a Julia condensation for preparation of an…”
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Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia by Brewer, Alison Campbell, Ruble, J. Craig, Vandeveer, H. George, Frank, Scott A, Nevill, C. Richard

“…Direct asymmetric reductive amination represents an efficient means of converting ketones to α-chiral primary amines, but reported examples are very limited…”
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Strategies for the Synthesis of Fusicoccanes by Nazarov Reactions of Dolabelladienones: Total Synthesis of (+)-Fusicoauritone by Williams, David R., Robinson, Leslie A., Nevill, C. Richard, Reddy, Jayachandra P.

“…Der Ring muss geschlossen werden: Der Schlüsselschritt eines Synthesewegs zu (+)‐Fusicoauriton (1) ist eine Julia‐Kondensation zur Bildung eines…”
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Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy by de Dios, Alfonso, Shih, Chuan, López de Uralde, Beatriz, Sánchez, Concepción, del Prado, Miriam, Martín Cabrejas, Luisa M, Pleite, Sehila, Blanco-Urgoiti, Jaime, Lorite, María José, Nevill, Jr, C Richard, Bonjouklian, Rosanne, York, Jeremy, Vieth, Michal, Wang, Yong, Magnus, Nicholas, Campbell, Robert M, Anderson, Bryan D, McCann, Denis J, Giera, Deborah D, Lee, Paul A, Schultz, Richard M, Li, Li C, Johnson, Lea M, Wolos, Jeffrey A

“…We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had…”
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Imidazolyl benzimidazoles and imidazo[4,5- b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties by Mader, Mary, de Dios, Alfonso, Shih, Chuan, Bonjouklian, Rosanne, Li, Tiechao, White, Wesley, de Uralde, Beatriz López, Sánchez-Martinez, Concepción, del Prado, Miriam, Jaramillo, Carlos, de Diego, Eugenio, Martín Cabrejas, Luisa M., Dominguez, Carmen, Montero, Carlos, Shepherd, Timothy, Dally, Robert, Toth, John E., Chatterjee, Arindam, Pleite, Sehila, Blanco-Urgoiti, Jaime, Perez, Leticia, Barberis, Mario, Lorite, María José, Jambrina, Enrique, Nevill, C. Richard, Lee, Paul A., Schultz, Richard C., Wolos, Jeffrey A., Li, Li C., Campbell, Robert M., Anderson, Bryan D.

“…The p38 MAP kinase activity of two series of trisubstituted imidazoles (X = C, N) is reported, leading to compounds with highly potent cellular and in vivo…”
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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties by Mader, Mary, de Dios, Alfonso, Shih, Chuan, Bonjouklian, Rosanne, Li, Tiechao, White, Wesley, López de Uralde, Beatriz, Sánchez-Martinez, Concepción, del Prado, Miriam, Jaramillo, Carlos, de Diego, Eugenio, Martín Cabrejas, Luisa M, Dominguez, Carmen, Montero, Carlos, Shepherd, Timothy, Dally, Robert, Toth, John E, Chatterjee, Arindam, Pleite, Sehila, Blanco-Urgoiti, Jaime, Perez, Leticia, Barberis, Mario, Lorite, María José, Jambrina, Enrique, Nevill, Jr, C Richard, Lee, Paul A, Schultz, Richard C, Wolos, Jeffrey A, Li, Li C, Campbell, Robert M, Anderson, Bryan D

“…Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing…”
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Strategies for the Synthesis of Fusicoccanes via Nazarov Reactions of Dolabelladienones. Total Synthesis of (+)-Fusicoauritone by Williams, David R., Robinson, Leslie A., Nevill, C. Richard, Reddy, Jayachandra P.

“…A synthetic pathway leading to (+)-fusicoauritone ( 1 ) is highlighted by the use of a Julia condensation for preparation of an eleven-membered…”
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Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy by de Dios, Alfonso, Shih, Chuan, López de Uralde, Beatriz, Sánchez, Concepción, del Prado, Miriam, Martín Cabrejas, Luisa M, Pleite, Sehila, Blanco-Urgoiti, Jaime, Lorite, María José, Nevill, C. Richard, Bonjouklian, Rosanne, York, Jeremy, Vieth, Michal, Wang, Yong, Magnus, Nicholas, Campbell, Robert M, Anderson, Bryan D, McCann, Denis J, Giera, Deborah D, Lee, Paul A, Schultz, Richard M, Li, Johnson, Lea M, Wolos, Jeffrey A

“…We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38α inhibitors. The lead compound 1 had low-nanomolar…”
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Synthesis of Imidazole Based p38 MAP (Mitogen-Activated Protein) Kinase Inhibitors under Buffered Conditions by Magnus, Nicholas A, Diseroad, William D, Nevill, C. Richard, Wepsiec, James P

“…This article describes chemistry that was developed to give access to multigram quantities of imidazole 479754 and several related analogues for Eli Lilly's…”
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A novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives by Nevill, C.Richard, Angell, Paul T.

“…Oxidation of carbamates with catalytic RuO 4, generated from RuO 2 and NaBrO 3, provides the corresponding acyl carbamates, which can be reduced with NaBH 4 to…”
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Chemical Development of MDL 103371:  An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke by Watson, Timothy J. N, Horgan, Stephen W, Shah, Ramnik S, Farr, Robert A, Schnettler, Richard A, Nevill, C. Richard, Weiberth, Franz J, Huber, Edward W, Baron, Bruce M, Webster, Mark E, Mishra, Rajesh K, Harrison, Boyd L, Nyce, Phillip L, Rand, Cynthia L, Goralski, Christian T

“…MDL 103371 is a N-methyl-d-aspartate (NMDA)-type glycine receptor antagonist for the potential treatment of stroke. Evaluation of five different synthetic…”
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Biochemical and pharmacological activity of arene-fused prostacyclin analogues on human platelets by Jakubowski, J A, Utterback, B G, Mais, D E, Hardinger, S A, Braish, T F, Nevill, C R, Fuchs, P L

“…Human platelets have been employed as an assay system to evaluate the pharmacological activity of a group of stable, arene-fused prostacyclin analogs…”
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