Search Results - "Nevill, C R"

Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy by de Dios, Alfonso, Shih, Chuan, López de Uralde, Beatriz, Sánchez, Concepción, del Prado, Miriam, Martín Cabrejas, Luisa M, Pleite, Sehila, Blanco-Urgoiti, Jaime, Lorite, María José, Nevill, C. Richard, Bonjouklian, Rosanne, York, Jeremy, Vieth, Michal, Wang, Yong, Magnus, Nicholas, Campbell, Robert M, Anderson, Bryan D, McCann, Denis J, Giera, Deborah D, Lee, Paul A, Schultz, Richard M, Li, Johnson, Lea M, Wolos, Jeffrey A

“…We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38α inhibitors. The lead compound 1 had low-nanomolar…”
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Chemical Development of MDL 103371:  An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke by Watson, Timothy J. N, Horgan, Stephen W, Shah, Ramnik S, Farr, Robert A, Schnettler, Richard A, Nevill, C. Richard, Weiberth, Franz J, Huber, Edward W, Baron, Bruce M, Webster, Mark E, Mishra, Rajesh K, Harrison, Boyd L, Nyce, Phillip L, Rand, Cynthia L, Goralski, Christian T

“…MDL 103371 is a N-methyl-d-aspartate (NMDA)-type glycine receptor antagonist for the potential treatment of stroke. Evaluation of five different synthetic…”
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Biochemical and pharmacological activity of arene-fused prostacyclin analogues on human platelets by Jakubowski, J A, Utterback, B G, Mais, D E, Hardinger, S A, Braish, T F, Nevill, C R, Fuchs, P L

“…Human platelets have been employed as an assay system to evaluate the pharmacological activity of a group of stable, arene-fused prostacyclin analogs…”
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Synthesis of Imidazole Based p38 MAP (Mitogen-Activated Protein) Kinase Inhibitors under Buffered Conditions by Magnus, Nicholas A, Diseroad, William D, Nevill, C. Richard, Wepsiec, James P

“…This article describes chemistry that was developed to give access to multigram quantities of imidazole 479754 and several related analogues for Eli Lilly's…”
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A novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives by Nevill, C.Richard, Angell, Paul T.

“…Oxidation of carbamates with catalytic RuO 4, generated from RuO 2 and NaBrO 3, provides the corresponding acyl carbamates, which can be reduced with NaBH 4 to…”
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