Search Results - "Neves, Susana R."

Decoding Information in Cell Shape by Rangamani, Padmini, Lipshtat, Azi, Azeloglu, Evren U., Calizo, Rhodora Cristina, Hu, Mufeng, Ghassemi, Saba, Hone, James, Scarlata, Suzanne, Neves, Susana R., Iyengar, Ravi

“…Shape is an indicator of cell health. But how is the information in shape decoded? We hypothesize that decoding occurs by modulation of signaling through…”
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G Protein Pathways by Neves, Susana R., Ram, Prahlad T., Iyengar, Ravi

“…The heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters,…”
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Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks by Neves, Susana R., Tsokas, Panayiotis, Sarkar, Anamika, Grace, Elizabeth A., Rangamani, Padmini, Taubenfeld, Stephen M., Alberini, Cristina M., Schaff, James C., Blitzer, Robert D., Moraru, Ion I., Iyengar, Ravi

“…The role of cell size and shape in controlling local intracellular signaling reactions, and how this spatial information originates and is propagated, is not…”
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ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion by Song, Roy S., Massenburg, Ben, Wenderski, Wendy, Jayaraman, Vino, Thompson, Lauren, Neves, Susana R.

“…AMPA-type glutamate receptor (AMPAR) trafficking is essential for modulating synaptic transmission strength. Prior studies that have characterized signaling…”
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Models of Spatially Restricted Biochemical Reaction Systems by Neves, Susana R., Iyengar, Ravi

“…Many reactions within the cell occur only in specific intracellular regions. Such local reaction networks give rise to microdomains of activated signaling…”
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Modeling of signaling networks by Neves, Susana R., Iyengar, Ravi

“…Biochemical networks, including those containing signaling pathways, display a wide range of regulatory properties. These include the ability to propagate…”
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Cell shape information is transduced through tension-independent mechanisms by Ron, Amit, Azeloglu, Evren U., Calizo, Rhodora C., Hu, Mufeng, Bhattacharya, Smiti, Chen, Yibang, Jayaraman, Gomathi, Lee, Sunwoo, Neves-Zaph, Susana R., Li, Hong, Gordon, Ronald E., He, John C., Hone, James C., Iyengar, Ravi

“…The shape of a cell within tissues can represent the history of chemical and physical signals that it encounters, but can information from cell shape regulate…”
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Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory by Havekes, Robbert, Park, Alan J, Tolentino, Rosa E, Bruinenberg, Vibeke M, Tudor, Jennifer C, Lee, Yool, Hansen, Rolf T, Guercio, Leonardo A, Linton, Edward, Neves-Zaph, Susana R, Meerlo, Peter, Baillie, George S, Houslay, Miles D, Abel, Ted

“…Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4…”
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Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking by Song, Roy S., Tolentino, Rosa, Sobie, Eric A., Neves-Zaph, Susana R.

“…Dopamine, a key striatal neuromodulator, increases synaptic strength by promoting surface insertion and/or retention of AMPA receptors (AMPARs). This process…”
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Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth by Bromberg, Kenneth D, Ma'ayan, Avi, Neves, Susana R, Iyengar, Ravi

“…Cannabinoid receptor 1 (CB1R) regulates neuronal differentiation. To understand the logic underlying decision-making in the signaling network controlling…”
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Obtaining and estimating kinetic parameters from the literature by Neves, Susana R

“…This Teaching Resource provides lecture notes, slides, and a student assignment for a lecture on strategies for the development of mathematical models. Many…”
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Developing models in virtual cell by Neves, Susana R

“…This Teaching Resource provides lecture notes, slides, and a student assignment for a two-part lecture on mathematical modeling using the Virtual Cell…”
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Interconnected network motifs control podocyte morphology and kidney function by Azeloglu, Evren U, Hardy, Simon V, Eungdamrong, Narat John, Chen, Yibang, Jayaraman, Gomathi, Chuang, Peter Y, Fang, Wei, Xiong, Huabao, Neves, Susana R, Jain, Mohit R, Li, Hong, Ma'ayan, Avi, Gordon, Ronald E, He, John Cijiang, Iyengar, Ravi

“…Podocytes are kidney cells with specialized morphology that is required for glomerular filtration. Diseases, such as diabetes, or drug exposure that causes…”
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Modeling of spatially-restricted intracellular signaling by Neves, Susana R.

“…Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but also because of the…”
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G Protein-regulated Inducer of Neurite Outgrowth (GRIN) Modulates Sprouty Protein Repression of Mitogen-activated Protein Kinase (MAPK) Activation by Growth Factor Stimulation by Hwangpo, Tracy Anh, Jordan, J. Dedrick, Premsrirut, Prem K., Jayamaran, Gomathi, Licht, Jonathan D., Iyengar, Ravi, Neves, Susana R.

“…Gαo/i interacts directly with GRIN (G protein-regulated inducer of neurite outgrowth). Using the yeast two-hybrid system, we identified Sprouty2 as an…”
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Modeling of spatial intracellular signaling events in neurons by Wenderski, Wendy C, Neves, Susana R

“…A neuron is able to seamlessly respond to a number of signals, in a timely and specific manner. This process, of integrating multiple inputs, relays on the…”
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Specification of Spatial Relationships in Directed Graphs of Cell Signaling Networks by Lipshtat, Azi, Neves, Susana R., Iyengar, Ravi

“…Graph theory provides a useful and powerful tool for the analysis of cellular signaling networks. Intracellular components such as cytoplasmic signaling…”
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Role of the Go/i signaling network in the regulation of neurite outgrowth by He, John Cijiang, Neves, Susana R, Jordan, J Dedrick, Iyengar, Ravi

“…Neurite outgrowth is a complex differentiation process stimulated by many neuronal growth factors and transmitters and by electrical activity. Among these…”
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An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells by Aaronson, David S., Muller, Melissa, Neves, Susana R., Chung, Wen-Chen, Jayaram, Gomathi, Iyengar, Ravi, Ram, Prahlad T.

“…Dynamic modulation of information flow within signaling networks allows the cell to respond to micro-environmental changes. This property of the cell, while…”
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Phosphodiesterase Diversity and Signal Processing Within cAMP Signaling Networks by Neves-Zaph, Susana R

“…A large number of neuromodulators activate G-protein coupled receptors (GPCRs) and mediate their cellular actions via the regulation of intracellular cAMP, the…”
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