Search Results - "Neves, Karla B."

Vascular toxicity associated with anti-angiogenic drugs by Neves, Karla B, Montezano, Augusto C, Lang, Ninian N, Touyz, Rhian M

“…Over the past two decades, the treatment of cancer has been revolutionised by the highly successful introduction of novel molecular targeted therapies and…”
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Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients by van Dorst, Daan C.H., Dobbin, Stephen J.H., Neves, Karla B., Herrmann, Joerg, Herrmann, Sandra M., Versmissen, Jorie, Mathijssen, Ron H.J., Danser, A.H. Jan, Lang, Ninian N.

“…The development of a wide range of novel antineoplastic therapies has improved the prognosis for patients with a wide range of malignancies, which has…”
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Tissue sodium excess is not hypertonic and reflects extracellular volume expansion by Rossitto, Giacomo, Mary, Sheon, Chen, Jun Yu, Boder, Philipp, Chew, Khai Syuen, Neves, Karla B., Alves, Rheure L., Montezano, Augusto C., Welsh, Paul, Petrie, Mark C., Graham, Delyth, Touyz, Rhian M., Delles, Christian

“…Our understanding of Na + homeostasis has recently been reshaped by the notion of skin as a depot for Na + accumulation in multiple cardiovascular diseases and…”
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Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension by Lopes, Rhéure A, Neves, Karla B, Tostes, Rita C, Montezano, Augusto C, Touyz, Rhian M

“…Oxidative stress is implicated in vascular dysfunction in hypertension. Although mechanisms regulating vascular pro-oxidants are emerging, there is a paucity…”
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Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity by Costa, Rafael M, Neves, Karla B, Tostes, Rita C, Lobato, Núbia S

“…Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary…”
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Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel by Alves-Lopes, Rhéure, Neves, Karla B., Anagnostopoulou, Aikaterini, Rios, Francisco J., Lacchini, Silvia, Montezano, Augusto C., Touyz, Rhian M.

“…Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are…”
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Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function by Zou, Zhi-Guo, Rios, Francisco J, Neves, Karla B, Alves-Lopes, Rheure, Ling, Jiayue, Baillie, George S, Gao, Xing, Fuller, William, Camargo, Livia L, Gudermann, Thomas, Chubanov, Vladimir, Montezano, Augusto C, Touyz, Rhian M

“…Transient receptor potential (TRP) melastatin 7 (TRPM7) cation channel, a dual-function ion channel/protein kinase, regulates vascular smooth muscle cell…”
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Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis by da Silva, Josiane Fernandes, Alves, Juliano V, Silva-Neto, Julio A, Costa, Rafael M, Neves, Karla B, Alves-Lopes, Rheure, Carmargo, Livia L, Rios, Francisco J, Montezano, Augusto C, Touyz, Rhian M, Tostes, Rita C

“…The mechanisms involved in NOX5 activation in atherosclerotic processes are not completely understood. The present study tested the hypothesis that…”
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SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication by Montezano, Augusto C., Camargo, Livia L., Mary, Sheon, Neves, Karla B, Rios, Francisco J, Stein, Ross, Lopes, Rheure A., Beattie, Wendy, Thomson, Jacqueline, Herder, Vanessa, Szemiel, Agnieszka M., McFarlane, Steven, Palmarini, Massimo, Touyz, Rhian M.

“…COVID-19, caused by SARS-CoV-2, is a respiratory disease associated with inflammation and endotheliitis. Mechanisms underling inflammatory processes are…”
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NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage by Bruder-Nascimento, Thiago, Ferreira, Nathanne S, Zanotto, Camila Z, Ramalho, Fernanda, Pequeno, Isabela O, Olivon, Vania C, Neves, Karla B, Alves-Lopes, Rheure, Campos, Eduardo, Silva, Carlos Alberto A, Fazan, Rubens, Carlos, Daniela, Mestriner, Fabiola L, Prado, Douglas, Pereira, Felipe V, Braga, Tarcio, Luiz, Joao Paulo M, Cau, Stefany B, Elias, Paula C, Moreira, Ayrton C, Câmara, Niels O, Zamboni, Dario S, Alves-Filho, Jose Carlos, Tostes, Rita C

“…BACKGROUND:Inflammation is a key feature of aldosterone-induced vascular damage and dysfunction, but molecular mechanisms by which aldosterone triggers…”
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Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway by Neves, Karla B, Morris, Hannah E, Alves-Lopes, Rhéure, Muir, Keith W, Moreton, Fiona, Delles, Christian, Montezano, Augusto C, Touyz, Rhian M

“…Notch3 mutations cause Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), which predisposes to stroke and…”
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Role of PARP and TRPM2 in VEGF Inhibitor-Induced Vascular Dysfunction by Neves, Karla B, Alves-Lopes, Rheure, Montezano, Augusto C, Touyz, Rhian M

“…Background Hypertension and vascular toxicity are major unwanted side effects of antiangiogenic drugs, such as vascular endothelial growth factor inhibitors…”
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NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function by Montezano, Augusto C, De Lucca Camargo, Livia, Persson, Patrik, Rios, Francisco J, Harvey, Adam P, Anagnostopoulou, Aikaterini, Palacios, Roberto, Gandara, Ana Caroline P, Alves-Lopes, Rheure, Neves, Karla B, Dulak-Lis, Maria, Holterman, Chet E, de Oliveira, Pedro Lagerblad, Graham, Delyth, Kennedy, Christopher, Touyz, Rhian M

“…NADPH Oxidase 5 (Nox5) is a calcium-sensitive superoxide-generating Nox. It is present in lower forms and higher mammals, but not in rodents. Nox5 is expressed…”
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Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus by Silva, Marcondes Alves B, Cau, Stefany Bruno A, Lopes, Rheure Alves M, Manzato, Carla P, Neves, Karla B, Bruder-Nascimento, Thiago, Mestriner, Fabiola Leslie Antunes C, Montezano, Augusto C, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M, Tostes, Rita C

“…Mineralocorticoid receptors (MRs), which are activated by mineralocorticoids and glucocorticoids, actively participate in mechanisms that affect the structure…”
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Comprehensive Characterization of the Vascular Effects of Cisplatin-Based Chemotherapy in Patients With Testicular Cancer by Cameron, Alan C., McMahon, Kelly, Hall, Mark, Neves, Karla B., Rios, Francisco J., Montezano, Augusto C., Welsh, Paul, Waterston, Ashita, White, Jeff, Mark, Patrick B., Touyz, Rhian M., Lang, Ninian N.

“…Cisplatin-based chemotherapy increases the risk of cardiovascular and renal disease. We aimed to define the time course, pathophysiology, and approaches to…”
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TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt by Rios, Francisco J., Zou, Zhi-Guo, Harvey, Adam P., Harvey, Katie Y., Camargo, Livia L., Neves, Karla B., Nichol, Sarah E. F., Alves-Lopes, Rheure, Cheah, Alexius, Zahraa, Maram, Ryazanov, Alexey G., Ryazanova, Lillia, Gudermann, Thomas, Chubanov, Vladimir, Montezano, Augusto C., Touyz, Rhian M.

“…Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg 2+ -permeable…”
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Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation by Alves-Lopes, Rh Ure, Neves, Karla B, Silva, Marcondes Ab, Olivon, Vânia C, Ruginsk, Silvia G, Antunes-Rodrigues, José, Ramalho, Leandra Nz, Tostes, Rita C, Carneiro, Fernando Silva

“…Androgen deficiency is strongly associated with erectile dysfunction (ED). Inadequate penile arterial blood flow is one of the major causes of ED. The blood…”
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Testosterone and vascular function in aging by Lopes, Rhéure A M, Neves, Karla B, Carneiro, Fernando S, Tostes, Rita C

“…Androgen receptors are widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Through classic cytosolic androgen…”
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Oxidative Stress: A Unifying Paradigm in Hypertension by Touyz, Rhian M., Rios, Francisco J., Alves-Lopes, Rhéure, Neves, Karla B., Camargo, Livia L., Montezano, Augusto C.

“…The etiology of hypertension involves complex interactions among genetic, environmental, and pathophysiologic factors that influence many regulatory systems…”
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VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes by Neves, Karla B, Rios, Francisco J, van der Mey, Lucas, Alves-Lopes, Rheure, Cameron, Alan C, Volpe, Massimo, Montezano, Augusto C, Savoia, Carmine, Touyz, Rhian M

“…Although VEGF (vascular endothelial growth factor) inhibitors (VEGFIs), are effective anticancer therapies, they cause hypertension through unknown mechanisms…”
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