The role of Mannose-binding lectin in leprosy: A systematic review

Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Mannose-binding lectin (MBL) is an acute phase protein associated with the pathophysiology of leprosy. Some studies have shown that there is a correlation between ser...

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Bibliographic Details
Published in:	Infection, genetics and evolution Vol. 93; p. 104945
Main Authors:	do Carmo, Rodrigo Feliciano, Neves, Jaime Rangel Leal, Oliveira, Pablo Rafael Silveira, Vasconcelos, Luydson Richardson Silva, de Souza, Carlos Dornels Freire
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-09-2021
Subjects:	Bacterial Proteins - metabolism Complement system Humans Innate immunity Leprosy Leprosy - metabolism Mannose-Binding Lectin - metabolism MBL2 Mycobacterium leprae - metabolism Polymorphism PB NOS OR MB MBL Leprosy SNPs Innate immunity Complement system MBL2 Polymorphism
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Summary:	Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Mannose-binding lectin (MBL) is an acute phase protein associated with the pathophysiology of leprosy. Some studies have shown that there is a correlation between serum levels of MBL and polymorphisms in its gene associated with susceptibility per se and to different clinical forms. The aim of this study was to conduct a systematic review of publications in the literature that studied the association of MBL with leprosy. Databases were searched until December 2020 (PROSPERO: CRD42020158458), and additional searches were conducted scanning the reference lists of the articles. Two independent reviewers assessed the study quality using the Newcastle-Ottawa Quality Assessment Scale. Finally, 10 eligible articles were included in the study. The overall results indicated that both low MBL serum levels and polymorphisms in the structural or promoter region of its gene seem to be associated as protective factors against the development of severe forms. The results suggest that MBL may play a role in the clinical progression of leprosy. •Evidence has shown that MBL could facilitate the ingestion and spread of intracellular pathogens through C3 opsonization•Genetic polymorphisms associated to low MBL serum levels can be advantageous in some situations.•The findings suggest that MBL2 variants may act as a protective factor for the development of multibacillary leprosy;
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1567-1348 1567-7257
DOI:	10.1016/j.meegid.2021.104945