Search Results - "Nevala, K"

Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma by Sakemura, Reona, Hefazi, Mehrdad, Siegler, Elizabeth L., Cox, Michelle J., Larson, Daniel P., Hansen, Michael J., Roman, Claudia Manriquez, Schick, Kendall J, Can, Ismail, Tapper, Erin E., Horvei, Paulina, Adada, Mohamad M., Bezerra, Evandro D., Fonkoua, Lionel Aurelien Kankeu, Ruff, Michael W., Nevala, Wendy K., Walters, Denise K., Parikh, Sameer A., Lin, Yi, Jelinek, Diane F., Kay, Neil E., Bergsagel, P. Leif, Kenderian, Saad S.

“…Pivotal clinical trials of B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed/refractory…”
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Understanding heterogeneous tumor microenvironment in metastatic melanoma by Yan, Yiyi, Leontovich, Alexey A, Gerdes, Michael J, Desai, Keyur, Dong, Jinhong, Sood, Anup, Santamaria-Pang, Alberto, Mansfield, Aaron S, Chadwick, Chrystal, Zhang, Rong, Nevala, Wendy K, Flotte, Thomas J, Ginty, Fiona, Markovic, Svetomir N

“…A systemic analysis of the tumor-immune interactions within the heterogeneous tumor microenvironment is of particular importance for understanding the…”
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Immunomodulatory Effects of Sex Hormones: Requirements for Pregnancy and Relevance in Melanoma by Enninga, Elizabeth Ann L., BS, Holtan, Shernan G., MD, Creedon, Douglas J., MD, PhD, Dronca, Roxana S., MD, Nevala, Wendy K., MS, Ognjanovic, Simona, PhD, Markovic, Svetomir N., MD, PhD

“…Abstract Similarities between the pathologic progression of cancer and the physiologic process of placentation (eg, proliferation, invasion, and local/systemic…”
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Evidence of Systemic Th2-Driven Chronic Inflammation in Patients with Metastatic Melanoma by Nevala, Wendy K, Vachon, Celine M, Leontovich, Alexey A, Scott, Christopher G, Thompson, Michael A, Markovic, Svetomir N

“…Purpose: Immunotherapeutic modalities are commonly used for treatment of patients with melanoma. The therapeutic success in preclinical models has not yielded…”
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Identification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma by Maus, Rachel L.G., Jakub, James W., Hieken, Tina J., Nevala, Wendy K., Christensen, Trace A., Sutor, Shari L., Flotte, Thomas J., Markovic, Svetomir N.

“…Epithelial tumors including melanoma often first metastasize to regional, sentinel lymph nodes (SLN). Thus, the presence of SLN metastases is a critical…”
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Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma by Frisch, Harold P, Sprau, Allan, McElroy, Virginia F, Turner, James D, Becher, Laura R E, Nevala, Wendy K, Leontovich, Alexey A, Markovic, Svetomir N

“…Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the…”
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Normal ageing is associated with an increase in Th2 cells, MCP‐1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF‐AA between sexes by Mansfield, A. S., Nevala, W. K., Dronca, R. S., Leontovich, A. A., Shuster, L., Markovic, S. N.

“…Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar…”
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Melanoma-Derived Extracellular Vesicles Induce CD36-Mediated Pre-Metastatic Niche by Suman, Shankar, Nevala, Wendy K, Leontovich, Alexey A, Ward, Caitlin, Jakub, James W, Kim, Yohan, Geng, Liyi, Stueven, Noah A, Atherton, Chathu L, Moore, Raymond M, Schimke, Jill M, Lucien-Matteoni, Fabrice, McLaughlin, Sarah A, Markovic, Svetomir N

“…CD36 expression in both immune and non-immune cells is known to be directly involved in cancer metastasis. Extracellular vesicles (EVs) secreted by malignant…”
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Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases by Markovic, Svetomir N., Enninga, Elizabeth Ann L., Creedon, Douglas J., Kaimal, Rajani, Chen, Y., Holtan, Shernan G., Nevala, Wendy K.

“…Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of…”
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Evidence of Th2 polarization of the sentinel lymph node (SLN) in melanoma by Grotz, Travis E, Jakub, James W, Mansfield, Aaron S, Goldenstein, Rachel, Enninga, Elizabeth Ann L, Nevala, Wendy K, Leontovich, Alexey A, Markovic, Svetomir N

“…Melanoma has a propensity for lymphatogenous metastasis. Improved understanding of the sentinel lymph node (SLN) immunological environment may improve…”
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Differential Response of Human and Mouse Dendritic Cells to VEGF Determines Interspecies Discrepancies in Tumor-Mediated Th1/Th2 Polarity Shift by BLOCK, Matthew S, NEVALA, Wendy K, LEONTOVICH, Alexey A, MARKOVIC, Svetomir N

“…Metastatic cancer patients exhibit systemic dysregulation of immune polarity and are biased toward Th-2 immune responses. This is due, at least in part, to…”
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GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts by Sterner, Rosalie M., Sakemura, Reona, Cox, Michelle J., Yang, Nan, Khadka, Roman H., Forsman, Cynthia L., Hansen, Michael J., Jin, Fang, Ayasoufi, Katayoun, Hefazi, Mehrdad, Schick, Kendall J., Walters, Denise K., Ahmed, Omar, Chappell, Dale, Sahmoud, Tarek, Durrant, Cameron, Nevala, Wendy K., Patnaik, Mrinal M., Pease, Larry R., Hedin, Karen E., Kay, Neil E., Johnson, Aaron J., Kenderian, Saad S.

“…Chimeric antigen receptor T (CAR-T) cell therapy is a new pillar in cancer therapeutics; however, its application is limited by the associated toxicities…”
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A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma by Markovic, Svetomir N, Suman, Vera J, Rao, Ravi A, Ingle, James N, Kaur, Judith S, Erickson, Lori A, Pitot, Henry C, Croghan, Gary A, McWilliams, Robert R, Merchan, Jaime, Kottschade, Lisa A, Nevala, Wendy K, Uhl, Cindy B, Allred, Jacob, Creagan, Edward T

“…Thrombospondins are natural inhibitors of angiogenesis, tumor metastases, and tumor growth (melanoma). ABT-510 is a synthetic analog of thrombospondin-1, well…”
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Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma by Holtan, Shernan G., Creedon, Douglas J., Thompson, Michael A., Nevala, Wendy K., Markovic, Svetomir N.

“…Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated…”
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Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia by Cox, Michelle J., Lucien, Fabrice, Sakemura, Reona, Boysen, Justin C., Kim, Yohan, Horvei, Paulina, Manriquez Roman, Claudia, Hansen, Michael J., Tapper, Erin E., Siegler, Elizabeth L., Forsman, Cynthia, Crotts, Sydney B., Schick, Kendall J., Hefazi, Mehrdad, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Nevala, Wendy K., Braggio, Esteban, Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.

“…Chimeric antigen receptor (CAR) T cell therapy has yielded unprecedented outcomes in some patients with hematological malignancies; however, inhibition by the…”
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Fetal Sex-Based Differences in Maternal Hormones, Angiogenic Factors, and Immune Mediators During Pregnancy and the Postpartum Period by Enninga, Elizabeth Ann L., Nevala, Wendy K., Creedon, Douglas J., Markovic, Svetomir N., Holtan, Shernan G.

“…Problem Several pregnancy complications have disparities based on the sex of the fetus. It is unknown whether the sex of the fetus differentially alters the…”
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Contraction of T cell richness in lung cancer brain metastases by Mansfield, Aaron S., Ren, Hongzheng, Sutor, Shari, Sarangi, Vivekananda, Nair, Asha, Davila, Jaime, Elsbernd, Laura R., Udell, Julia B., Dronca, Roxana S., Park, Sean, Markovic, Svetomir N., Sun, Zhifu, Halling, Kevin C., Nevala, Wendy K., Aubry, Marie Christine, Dong, Haidong, Jen, Jin

“…Very little is known about how the adaptive immune system responds to clonal evolution and tumor heterogeneity in non-small cell lung cancer. We profiled the…”
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CD206‐positive myeloid cells bind galectin‐9 and promote a tumor‐supportive microenvironment by Enninga, Elizabeth Ann L, Chatzopoulos, Kyriakos, Butterfield, John T, Sutor, Shari L, Leontovich, Alexey A, Nevala, Wendy K, Flotte, Thomas J, Markovic, Svetomir N

“…In patients with metastatic melanoma, high blood levels of galectin‐9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state…”
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Antibody-targeted paclitaxel loaded nanoparticles for the treatment of CD20+ B-cell lymphoma by Nevala, Wendy K., Butterfield, John T., Sutor, Shari L., Knauer, Daniel J., Markovic, Svetomir N.

“…We developed a nano-antibody targeted chemotherapy (nATC) delivery strategy in which tumor specific and clinically relevant antibodies (rituximab, anti-CD20)…”
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Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma by Enninga, Elizabeth Ann L, Nevala, Wendy K, Holtan, Shernan G, Leontovich, Alexey A, Markovic, Svetomir N

“…Galectin-9, a β-galactoside-binding protein, is defined as a negative regulator of T helper 1 (Th1) immune responses, favoring Th2 bias. Systemic immunity in…”
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