Search Results - "Neuwald, A F"

HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions by Neuwald, A F, Hirano, T

“…HEAT repeats correspond to tandemly arranged curlicue-like structures that appear to serve as flexible scaffolding on which other components can assemble…”
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Barth syndrome may be due to an acyltransferase deficiency by Neuwald, Andrew F

“…Barth syndrome is an X-linked inherited disorder characterized by short stature, cardioskeletal myopathy, neutropenia, abnormal mitochondria, and…”
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Extracting protein alignment models from the sequence database by Neuwald, A.F, Liu, J.S, Lipman, D.J, Lawrence, C.E

“…Biologists often gain structural and functional insights into a protein sequence by constructing a multiple alignment model of the family. Here a program…”
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An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases by Neuwald, Andrew F.

“…The mechanism of a membrane‐bound enzyme important in phospholipid signaling, type 2 phosphatidic acid phosphatase, is suggested by sequence motifs shared with…”
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Gibbs motif sampling: Detection of bacterial outer membrane protein repeats by Neuwald, Andrew F., Liu, Jun S., Lawrence, Charles E.

“…The detection and alignment of locally conserved regions (motifs) in multiple sequences can provide insight into protein structure, function, and evolution. A…”
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PSI-BLAST searches using hidden markov models of structural repeats: prediction of an unusual sliding DNA clamp and of beta-propellers in UV-damaged DNA-binding protein by Neuwald, A F, Poleksic, A

“…We have designed hidden Markov models (HMMs) of structurally conserved repeats that, based on pairwise comparisons, are unconserved at the sequence level. To…”
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Differential Contributions of Condensin I and Condensin II to Mitotic Chromosome Architecture in Vertebrate Cells by Ono, Takao, Losada, Ana, Hirano, Michiko, Myers, Michael P., Neuwald, Andrew F., Hirano, Tatsuya

“…The canonical condensin complex (henceforth condensin I) plays an essential role in mitotic chromosome assembly and segregation from yeast to humans. We report…”
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Detecting patterns in protein sequences by Neuwald, A F, Green, P

“…The detection of conserved sequence patterns (motifs) in related proteins often yields valuable structural and functional insights. We describe a method that…”
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AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes by Neuwald, A F, Aravind, L, Spouge, J L, Koonin, E V

“…Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein sequences related to the AAA…”
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cysQ, a gene needed for cysteine synthesis in Escherichia coli K-12 only during aerobic growth by NEUWALD, A. F, RAJENDRA KRISHNAN, B, BRIKUN, I, KULAKAUSKAS, S, SUZIEDELIS, K, TOMCSANYI, T, LEYH, T. S, BERG, D. E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein by Neuwald, Andrew F., Landsman, David

“…Acetylation of histone amino-terminal tail domains has long been associated with transcriptionally active chromatin. Recently, histone acetyltransferase (HAT)…”
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Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain by NEUWALD, A. F, KOONIN, E. V

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Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling by Aravind, L., Neuwald, Andrew F., Ponting, Chris P.

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Detection of likely transmembrane beta strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler by Mannella, C A, Neuwald, A F, Lawrence, C E

“…The mitochondrial channel VDAC is presumed to fold as a beta-barrel although the number and identity of transmembrane beta-strands in the protein are…”
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A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins by Bork, Peer, Hofmann, Kay, Bucher, Philipp, Neuwald, Andrew F., Altschul, Stephen F., Koonin, Eugene V.

“…Computer analysis of a conserved domain, BRCT, first described at the carboxyl ter‐minus of the breast cancer protein BRCA1, a p53 binding protein (53BP1), and…”
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Purification and biochemical characterization of interchromatin granule clusters by Mintz, Paul J, Patterson, Scott D, Neuwald, Andrew F, Spahr, Chris S, Spector, David L

“…Components of the pre‐mRNA splicing machinery are localized in interchromatin granule clusters (IGCs) and perichromatin fibrils (PFs). Here we report the…”
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Detecting Subtle Sequence Signals: A Gibbs Sampling Strategy for Multiple Alignment by Lawrence, Charles E., Altschul, Stephen F., Boguski, Mark S., Liu, Jun S., Neuwald, Andrew F., Wootton, John C.

“…A wealth of protein and DNA sequence data is being generated by genome projects and other sequencing efforts. A crucial barrier to deciphering these sequences…”
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Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPases by Neuwald, Andrew F

“…Ring-shaped sliding clamps encircle DNA and bind to DNA polymerase, thereby preventing it from falling off during DNA replication. In eukaryotes, sliding…”
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Diverse proteins homologous to inositol monophosphatase by Neuwald, Andrew F., York, John D., Majerus, Philip W.

“…Bovine inositol monophosphatase (IMP) and several homologous proteins were found to share two sequence motifs with bovine inositol polyphosphate 1-phosphatase…”
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A shared domain between a spindle assembly checkpoint protein and Ypt/Rab-specific GTPase-activators by Neuwald, Andrew F.

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