Search Results - "Neutzner, Albert"

mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division by Karbowski, Mariusz, Neutzner, Albert, Youle, Richard J

“…We identify a mitochondrial E3 ubiquitin ligase, MARCH5, as a critical regulator of mitochondrial fission. MARCH5 RING mutants and MARCH5 RNA interference…”
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Enzymes of ubiquitination and deubiquitination by Neutzner, Melanie, Neutzner, Albert

“…Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by…”
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Changes to the Aqueous Humor Proteome during Glaucoma by Kaeslin, Martha Andrea, Killer, Hanspeter Ezriel, Fuhrer, Cyril Adrian, Zeleny, Nauke, Huber, Andreas Robert, Neutzner, Albert

“…To investigate the aqueous humor proteome in patients with glaucoma and a control group. Aqueous humor was obtained from five human donors diagnosed with…”
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Neurodegeneration as a consequence of failed mitochondrial maintenance by Karbowski, Mariusz, Neutzner, Albert

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Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 by Park, Yong-Yea, Lee, Seungmin, Karbowski, Mariusz, Neutzner, Albert, Youle, Richard J, Cho, Hyeseong

“…Mitochondria constantly divide and combine through fission and fusion activities. MARCH5, a mitochondrial E3 ubiquitin ligase, has been identified as a…”
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Quality control of oxidatively damaged mitochondrial proteins is mediated by p97 and the proteasome by Hemion, Charles, Flammer, Josef, Neutzner, Albert

“…Protein quality control is essential for maintaining mitochondrial fidelity. Proteins damaged by reactive oxygen species necessitate quality control to prevent…”
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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 by Restelli, Lisa Michelle, Oettinghaus, Björn, Halliday, Mark, Agca, Cavit, Licci, Maria, Sironi, Lara, Savoia, Claudia, Hench, Jürgen, Tolnay, Markus, Neutzner, Albert, Schmidt, Alexander, Eckert, Anne, Mallucci, Giovanna, Scorrano, Luca, Frank, Stephan

“…Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not…”
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UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy by Bento, Ana C., Bippes, Claudia C., Kohler, Corina, Hemion, Charles, Frank, Stephan, Neutzner, Albert

“…Clearance of damaged mitochondria through mitophagy is critical for maintaining mitochondrial fidelity and the prevention of neurodegeneration. Here, we report…”
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Impact of aging on meningeal gene expression by Neutzner, Melanie, Kohler, Corina, Frank, Stephan, Killer, Hanspeter E, Neutzner, Albert

“…The three-layered meninges cover and protect the central nervous system and form the interface between cerebrospinal fluid and the brain. They are host to a…”
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Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy by Fogel, Adam I., Dlouhy, Brian J., Wang, Chunxin, Ryu, Seung-Wook, Neutzner, Albert, Hasson, Samuel A., Sideris, Dionisia P., Abeliovich, Hagai, Youle, Richard J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease by Sironi, Lara, Restelli, Lisa Michelle, Tolnay, Markus, Neutzner, Albert, Frank, Stephan

“…The pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial…”
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Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve by Rossinelli, Diego, Fourestey, Gilles, Killer, Hanspeter Esriel, Neutzner, Albert, Iaccarino, Gianluca, Remonda, Luca, Berberat, Jatta

“…Impaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve…”
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Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission by Lussier, Marc P, Herring, Bruce E, Nasu-Nishimura, Yukiko, Neutzner, Albert, Karbowski, Mariusz, Youle, Richard J, Nicoll, Roger A, Roche, Katherine W

“…AMPA receptors (AMPARs) mediate the majority of fast excitatory neurotransmission, and their density at postsynaptic sites determines synaptic strength…”
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Large-scale morphometry of the subarachnoid space of the optic nerve by Rossinelli, Diego, Killer, Hanspeter Esriel, Meyer, Peter, Knott, Graham, Fourestey, Gilles, Kurtcuoglu, Vartan, Kohler, Corina, Gruber, Philipp, Remonda, Luca, Neutzner, Albert, Berberat, Jatta

“…The meninges, formed by dura, arachnoid and pia mater, cover the central nervous system and provide important barrier functions. Located between arachnoid and…”
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IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation by Benard, Giovanni, Neutzner, Albert, Peng, Guihong, Wang, Chunxin, Livak, Ferenc, Youle, Richard J, Karbowski, Mariusz

“…Bax, a pro‐apoptotic protein from the Bcl‐2 family, is central to apoptosis regulation. To suppress spontaneous apoptosis, Bax must be under stringent control…”
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E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP by Bist, Pradeep, Cheong, Wan Shoo, Ng, Aylwin, Dikshit, Neha, Kim, Bae-Hoon, Pulloor, Niyas Kudukkil, Khameneh, Hanif Javanmard, Hedl, Matija, Shenoy, Avinash R., Balamuralidhar, Vanniarajan, Malik, Najib Bin Abdul, Hong, Michelle, Neutzner, Albert, Chin, Keh-Chuang, Kobayashi, Koichi S., Bertoletti, Antonio, Mortellaro, Alessandra, Abraham, Clara, MacMicking, John D., Xavier, Ramnik J., Sukumaran, Bindu

“…Optimal regulation of the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is essential for controlling bacterial…”
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A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis by Neutzner, Albert, Neutzner, Melanie, Benischke, Anne-Sophie, Ryu, Seung-Wook, Frank, Stephan, Youle, Richard J., Karbowski, Mariusz

“…To identify novel regulators of endoplasmic reticulum (ER)-linked protein degradation and ER function, we determined the entire inventory of membrane-spanning…”
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Instability of the Mitofusin Fzo1 Regulates Mitochondrial Morphology during the Mating Response of the Yeast Saccharomyces cerevisiae by Neutzner, Albert, Youle, Richard J.

“…Mitochondria form a highly dynamic network that is shaped by continuous fission and fusion of these organelles. In the yeast Saccharomyces cerevisiae two…”
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PGC-1α determines light damage susceptibility of the murine retina by Egger, Anna, Samardzija, Marijana, Sothilingam, Vithiyanjali, Tanimoto, Naoyuki, Lange, Christina, Salatino, Silvia, Fang, Lei, Garcia-Garrido, Marina, Beck, Susanne, Okoniewski, Michal J, Neutzner, Albert, Seeliger, Mathias W, Grimm, Christian, Handschin, Christoph

“…The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in…”
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Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model by Fang, Lei, Hemion, Charles, Goldblum, David, Meyer, Peter, Orgül, Selim, Frank, Stephan, Flammer, Josef, Neutzner, Albert

“…To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal…”
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