Hippocampal subfield plasticity is associated with improved spatial memory

Hippocampal subfield plasticity is associated with improved spatial memory

Physical exercise studies are generally underrepresented in young adulthood. Seventeen subjects were randomized into an intervention group (24.2 ± 3.9 years; 3 trainings/week) and 10 subjects into a passive control group (23.7 ± 4.2 years), over a duration of 6 months. Every two months, performance...

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Published in:Communications biology Vol. 7; no. 1; p. 271
Main Authors: Boecker, Henning, Daamen, Marcel, Kunz, Lukas, Geiß, Melanie, Müller, Moritz, Neuss, Thomas, Henschel, Leonie, Stirnberg, Rüdiger, Upadhyay, Neeraj, Scheef, Lukas, Martin, Jason A., Stöcker, Tony, Radbruch, Alexander, Attenberger, Ulrike, Axmacher, Nikolai, Maurer, Angelika
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 05-03-2024
Nature Publishing Group
Nature Portfolio
Subjects:
59/57
631/378/1595/1554
631/378/2612
Adult
Ammon's horn
Biomedical and Life Sciences
Body Composition
Cardiorespiratory fitness
Cognition
Dentate gyrus
Exercise
Hippocampal plasticity
Hippocampus
Hippocampus - diagnostic imaging
Humans
Life Sciences
Magnetic resonance imaging
Physical fitness
Physical training
Spatial Memory
Subiculum
Young Adult
Young adults
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Summary:Physical exercise studies are generally underrepresented in young adulthood. Seventeen subjects were randomized into an intervention group (24.2 ± 3.9 years; 3 trainings/week) and 10 subjects into a passive control group (23.7 ± 4.2 years), over a duration of 6 months. Every two months, performance diagnostics, computerized spatial memory tests, and 3 Tesla magnetic resonance imaging were conducted. Here we find that the intervention group, compared to controls, showed increased cardiorespiratory fitness, spatial memory performance and subregional hippocampal volumes over time. Time-by-condition interactions occurred in right cornu ammonis 4 body and (trend only) dentate gyrus, left hippocampal tail and left subiculum. Increases in spatial memory performance correlated with hippocampal body volume changes and, subregionally, with left subicular volume changes. In conclusion, findings support earlier reports of exercise-induced subregional hippocampal volume changes. Such exercise-related plasticity may not only be of interest for young adults with clinical disorders of hippocampal function, but also for sedentary normal cohorts. A structural MRI study suggests that regular exercise training induces plasticity in hippocampal subregions also in young adults. Hippocampal plasticity correlates with changes in spatial memory precision.
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ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-05949-5