Search Results - "Neuroscience letters"

The cerebellum and cognition by Schmahmann, Jeremy D.

“…•Cerebrocerebellar connections confer functional topography on cerebellar organization.•Sensorimotor processing is represented principally in the cerebellar…”
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The role of mitochondria in amyotrophic lateral sclerosis by Smith, Emma F., Shaw, Pamela J., De Vos, Kurt J.

“…•Mitochondrial dysfunction is one of the earliest pathophysiological events in amyotrophic lateral sclerosis (ALS).•ALS-associated mutant proteins accumulate…”
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The complexity of tau in Alzheimer’s disease by Naseri, Nima N., Wang, Hong, Guo, Jennifer, Sharma, Manu, Luo, Wenjie

“…•Pathogenic tau species disrupt synaptic functions at the pre-and-post-synapse.•Acetylation has emerged as a novel pathological modification of tau.•Seeding…”
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Blood-brain barrier regulation in psychiatric disorders by Kealy, John, Greene, Chris, Campbell, Matthew

“…•The blood-brain barrier (BBB) forms a critical interface between the brain and blood circulation.•Loss of BBB integrity appears to be a common pathological…”
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Neurological issues in children with COVID-19 by Lin, Jieru E., Asfour, Arsenoi, Sewell, Taylor B., Hooe, Benjamin, Pryce, Patrice, Earley, Chelsea, Shen, Min Ye, Kerner-Rossi, Mallory, Thakur, Kiran T., Vargas, Wendy S., Silver, Wendy G., Geneslaw, Andrew S.

“…•Headache, altered mental status and weakness are the most common reported neurological symptoms in children.•Severe complications such as demyelinating…”
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Development of the emotional brain by Casey, B.J., Heller, Aaron S., Gee, Dylan G., Cohen, Alexandra O.

“…[Display omitted] •Adolescence is a period of increased reactivity to emotional and social cues.•Subcortical limbic connectivity is associated with cue-driven…”
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Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? by Bourassa, Megan W., Alim, Ishraq, Bultman, Scott J., Ratan, Rajiv R.

“…•Interest in how diet influences brain function via the gut microbiome is growing.•Butyrate can protect the brain and enhance plasticity in neurological…”
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α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies by Henderson, Michael X., Trojanowski, John Q., Lee, Virginia M.-Y.

“…•α-Synuclein is the major component of Lewy bodies and is thought to be pathogenic in Parkinson’s and related diseases.•Work in humans and model systems has…”
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The hippocampus and related neocortical structures in memory transformation by Sekeres, Melanie J., Winocur, Gordon, Moscovitch, Morris

“…•Recent evidence on memory consolidation and transformation in humans and rodents is reviewed and theories are evaluated.•With time and experience, memory…”
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Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease by Ota, Miho, Matsuo, Junko, Ishida, Ikki, Takano, Harumasa, Yokoi, Yuma, Hori, Hiroaki, Yoshida, Sumiko, Ashida, Kinya, Nakamura, Kentaro, Takahashi, Takeshi, Kunugi, Hiroshi

“…•Single intake of ketogenic formula increases the concentration of ketone bodies.•Chronic consumption of the ketogenic formula ameliorate the cognition of AD…”
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What can we learn from brain autopsies in COVID-19? by Mukerji, Shibani S., Solomon, Isaac H.

“…•Chronic neurological disease and acute abnormalities are present in COVID-19 brain autopsies.•Acute hypoxic-injury, hemorrhage, and minimal inflammation are…”
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Variability in non-invasive brain stimulation studies: Reasons and results by Guerra, Andrea, López-Alonso, Virginia, Cheeran, Binith, Suppa, Antonio

“…•Mechanisms responsible for TBS, PAS and tDCS-induced plasticity are described.•Measures of intra and inter subject variability in NIBS studies are…”
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Astrocyte activation and reactive gliosis—A new target in stroke? by Pekny, Milos, Wilhelmsson, Ulrika, Tatlisumak, Turgut, Pekna, Marcela

“…•The response of astrocytes to injury is a major determinant of the outcome after stroke.•In the acute phase, reactive astrocytes are neuroprotective.•In the…”
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The dual role of astrocyte activation and reactive gliosis by Pekny, Milos, Wilhelmsson, Ulrika, Pekna, Marcela

“…•Astrocyte activation (AA) and reactive gliosis (RG) accompany many CNS pathologies.•AA and RG alter the expression of many genes and astrocyte function.•RG…”
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Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways by Park, Junghyung, Min, Ju-Sik, Kim, Bokyung, Chae, Un-Bin, Yun, Jong Won, Choi, Myung-Sook, Kong, Il-Keun, Chang, Kyu-Tae, Lee, Dong-Seok

“…•Mito-TEMPO attenuates LPS-induced increase of mitochondrial ROS levels in microglia.•Mito-TEMPO prevents elevated levels of intracellular ROS in activated…”
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The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research by Fox, Andrew S., Shackman, Alexander J.

“…•Central extended amygdala (EAc) encompasses Ce and BST.•EAc is engaged by a range of threat-relevant cues.•Optogenetic/chemogenetic studies reveal key…”
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Cortico-limbic pain mechanisms by Thompson, Jeremy M., Neugebauer, Volker

“…Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain represents a complex disorder with anxio-depressive symptoms and…”
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Stroke in patients with COVID-19: Clinical and neuroimaging characteristics by Vogrig, Alberto, Gigli, Gian Luigi, Bnà, Claudio, Morassi, Mauro

“…•Stroke is an infrequent, but potentially life-threatening, complication of COVID-19.•Typical features include large vessel occlusion and multi-territory…”
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Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms? by Carozzi, V.A., Canta, A., Chiorazzi, A.

“…•Platins, taxanes, vincalkaloids, proteasome inhibitors are effective anticancer drugs.•Clinical use causes peripheral neurotoxicity impairing patients’…”
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Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia by Liu, Yang, Dai, Yue, Li, Qing, Chen, Chen, Chen, Hao, Song, Yuanjian, Hua, Fang, Zhang, Zuohui

“…•Aβ1−42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ1−42-induced…”
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