Search Results - "Neuroscience"

Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear by Wu, P.Z., Liberman, L.D., Bennett, K., de Gruttola, V., O'Malley, J.T., Liberman, M.C.

“…•Hair-cell and auditory-nerve loss were quantified in 20 “normal” humans 0–86 yrs.•Age-related loss of nerve fibers exceeded the rate of hair cell loss by…”
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A Transfer Learning Approach for Early Diagnosis of Alzheimer’s Disease on MRI Images by Mehmood, Atif, Yang, Shuyuan, Feng, Zhixi, Wang, Min, Ahmad, AL Smadi, Khan, Rizwan, Maqsood, Muazzam, Yaqub, Muhammad

“…•We developed a layer-wise transfer learning model for Alzheimer’s Disease (AD) classification.•We predict the best results on binary class classification such…”
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Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia by Paolicelli, Rosa C., Bergamini, Giorgio, Rajendran, Lawrence

“…•Extracellular vesicles are important mediators of cell-to-cell communication.•Microglia serve as source and recipient of extracellular vesicles in the…”
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Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review by Abrahams, Shameemah, Haylett, William L., Johnson, Glynis, Carr, Jonathan A., Bardien, Soraya

“…The global burden of neurodegenerative disorders has increased substantially over the past 2 decades due to rising rates of population aging. Although…”
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The neural basis of reversal learning: An updated perspective by Izquierdo, A, Brigman, J.L, Radke, A.K, Rudebeck, P.H, Holmes, A

“…Highlights • Reversal learning is a widely used test of cognitive flexibility across species. • The idea that this learning primarily measures response…”
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Neurobiology of fibromyalgia and chronic widespread pain by Sluka, Kathleen A, Clauw, Daniel J

“…Highlights • Fibromyalgia is associated with altered processing in the CNS with enhanced excitability and decreased inhibition. • Animal models mimicking…”
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The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder by Faraone, Stephen V., Banaschewski, Tobias, Coghill, David, Zheng, Yi, Biederman, Joseph, Bellgrove, Mark A., Newcorn, Jeffrey H., Gignac, Martin, Al Saud, Nouf M., Manor, Iris, Rohde, Luis Augusto, Yang, Li, Cortese, Samuele, Almagor, Doron, Stein, Mark A., Albatti, Turki H., Aljoudi, Haya F., Alqahtani, Mohammed M.J., Asherson, Philip, Atwoli, Lukoye, Bölte, Sven, Buitelaar, Jan K., Crunelle, Cleo L., Daley, David, Dalsgaard, Søren, Döpfner, Manfred, Espinet (on behalf of CADDRA), Stacey, Fitzgerald, Michael, Franke, Barbara, Gerlach, Manfred, Haavik, Jan, Hartman, Catharina A., Hartung, Cynthia M., Hinshaw, Stephen P., Hoekstra, Pieter J., Hollis, Chris, Kollins, Scott H., Sandra Kooij, J.J., Kuntsi, Jonna, Larsson, Henrik, Li, Tingyu, Liu, Jing, Merzon, Eugene, Mattingly, Gregory, Mattos, Paulo, McCarthy, Suzanne, Mikami, Amori Yee, Molina, Brooke S.G., Nigg, Joel T., Purper-Ouakil, Diane, Omigbodun, Olayinka O., Polanczyk, Guilherme V., Pollak, Yehuda, Poulton, Alison S., Rajkumar, Ravi Philip, Reding, Andrew, Reif, Andreas, Rubia, Katya, Rucklidge, Julia, Romanos, Marcel, Ramos-Quiroga, J. Antoni, Schellekens, Arnt, Scheres, Anouk, Schoeman, Renata, Schweitzer, Julie B., Shah, Henal, Solanto, Mary V., Sonuga-Barke, Edmund, Soutullo, César, Steinhausen, Hans-Christoph, Swanson, James M., Thapar, Anita, Tripp, Gail, van de Glind, Geurt, van den Brink, Wim, Van der Oord, Saskia, Venter, Andre, Vitiello, Benedetto, Walitza, Susanne, Wang, Yufeng

“…•ADHD occurs in 5.9 % of youth and 2.5 % of adults.•Most cases of ADHD are caused by the combined effects of many genetic and environmental risks.•There are…”
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Great Expectations: Is there Evidence for Predictive Coding in Auditory Cortex? by Heilbron, Micha, Chait, Maria

“…•Predictive coding (PC) aims to offer a unified theory of cortical function.•We evaluate five assumptions of PC in the context of auditory pattern processing…”
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Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress by Liang, S, Wang, T, Hu, X, Luo, J, Li, W, Wu, X, Duan, Y, Jin, F

“…Graphical abstract…”
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Diversity and Specificity of Astrocyte–neuron Communication by Durkee, Caitlin A., Araque, Alfonso

“…•Astrocytes are emerging as important players in synaptic function.•Mechanisms and consequences of astrocyte–neuron signaling is a complex…”
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G-Protein-Coupled Receptors in Astrocyte–Neuron Communication by Kofuji, Paulo, Araque, Alfonso

“…•Astrocytes sense synaptic activity through G protein-coupled receptor activation.•GPCR activation in astrocytes increases their intracellular calcium.•GPCR…”
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Pathogenesis of depression: Insights from human and rodent studies by Ménard, C, Hodes, G.E, Russo, S.J

“…Graphical abstract…”
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The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders by Réus, G.Z, Fries, G.R, Stertz, L, Badawy, M, Passos, I.C, Barichello, T, Kapczinski, F, Quevedo, J

“…Highlights • Microglial activation is evident in psychiatric conditions. • It is not clear if microglia activation can lead to the onset of psychiatric…”
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Influence of maternal thyroid hormones during gestation on fetal brain development by Moog, N.K, Entringer, S, Heim, C, Wadhwa, P.D, Kathmann, N, Buss, C

“…Highlights • Thyroid hormones (THs) are crucial for key maturational processes during early brain development. • Maternal TH deficiency during pregnancy may…”
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The serotonin system in autism spectrum disorder: From biomarker to animal models by Muller, C.L, Anacker, A.M.J, Veenstra-VanderWeele, J

“…Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a…”
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Opioid-induced hyperalgesia: Cellular and molecular mechanisms by Roeckel, Laurie-Anne, Le Coz, Glenn-Marie, Gavériaux-Ruff, Claire, Simonin, Frédéric

“…Highlights • The cellular and molecular mechanisms of opioid-induced hyperalgesia (OIH). • The different factors that influence the development of OIH. • The…”
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Hypoxia Inducible Factor-1α (HIF-1α) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke by Jiang, Qian, Geng, Xiaokun, Warren, Jonathan, Eugene Paul Cosky, Eric, Kaura, Shawn, Stone, Christopher, Li, Fengwu, Ding, Yuchuan

“…[Display omitted] •Activation of NLRP3 inflammasome subsequently activates pyroptosis and apoptosis.•HIF-1α mediates NLRP3 inflammasome-dependent-pyroptotic…”
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The Interaction of Person-Affect-Cognition-Execution (I-PACE) model for addictive behaviors: Update, generalization to addictive behaviors beyond internet-use disorders, and specification of the process character of addictive behaviors by Brand, Matthias, Wegmann, Elisa, Stark, Rudolf, Müller, Astrid, Wölfling, Klaus, Robbins, Trevor W., Potenza, Marc N.

“…•Addictive behaviors are linked to cue-reactivity and craving.•Addictive behaviors are associated with diminished inhibitory control.•Habitual behaviors are…”
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Astrocytes in physiological aging and Alzheimer’s disease by Rodríguez-Arellano, J.J, Parpura, V, Zorec, R, Verkhratsky, A

“…Highlights • Astrocytes are fundamental for homoeostasis, defence and regeneration of the CNS. • In Alzheimer’s disease (AD) astrocytes undergo degeneration…”
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Untreated depression during pregnancy: Short- and long-term effects in offspring. A systematic review by Gentile, S

“…Highlights • Untreated antenatal depression may have devastating effects on the fetus (75). • Negative repercussions were also found in newborns children, and…”
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