Search Results - "Neurobiology of learning and memory"

From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders by VanElzakker, Michael B., Kathryn Dahlgren, M., Caroline Davis, F., Dubois, Stacey, Shin, Lisa M.

“…•Pavlovian fear conditioning and extinction relate to PTSD and other anxiety disorders.•Such studies in rodents inform human psychophysiological and…”
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Tracking the flow of hippocampal computation: Pattern separation, pattern completion, and attractor dynamics by Knierim, James J., Neunuebel, Joshua P.

“…•Experiments testing classic computational theories of hippocampus are reviewed.•LEC and MEC provided conflicting inputs to hippocampus.•DG performed pattern…”
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Acute exercise improves motor memory: Exploring potential biomarkers by Skriver, Kasper, Roig, Marc, Lundbye-Jensen, Jesper, Pingel, Jessica, Helge, Jørn Wulff, Kiens, Bente, Nielsen, Jens Bo

“…•Following either an intense bout of cycling or rest subjects practiced a motor task.•Blood concentrations of specific biomarkers increased after…”
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Cognitive deficits in single App knock-in mouse models by Masuda, Akira, Kobayashi, Yuki, Kogo, Naomi, Saito, Takashi, Saido, Takaomi C., Itohara, Shigeyoshi

“…[Display omitted] •App-KI mice carrying NL-G-F mutations showed deficits in broad cognitive domains.•App-KI mice carrying NL-F mutations showed moderate…”
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Prefrontal–hippocampal pathways underlying inhibitory control over memory by Anderson, Michael C., Bunce, Jamie G., Barbas, Helen

“…•Retrieval suppression is a model for understanding inhibitory control over thought.•Suppression engages dorsolateral prefrontal cortex (DLPFC), reducing…”
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Pattern separation, completion, and categorisation in the hippocampus and neocortex by Rolls, Edmund T.

“…•Pattern separation and completion in the hippocampus and neocortex are described.•A quantitative computational theory of the hippocampus is developed…”
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Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: From adaptive responses to psychopathologies by Finsterwald, Charles, Alberini, Cristina M.

“…A proper response against stressors is critical for survival. In mammals, the stress response is primarily mediated by secretion of glucocorticoids via the…”
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Habituation revisited: An updated and revised description of the behavioral characteristics of habituation by Rankin, Catharine H., Abrams, Thomas, Barry, Robert J., Bhatnagar, Seema, Clayton, David F., Colombo, John, Coppola, Gianluca, Geyer, Mark A., Glanzman, David L., Marsland, Stephen, McSweeney, Frances K., Wilson, Donald A., Wu, Chun-Fang, Thompson, Richard F.

“…The most commonly cited descriptions of the behavioral characteristics of habituation come from two papers published almost 40 years ago [Groves, P. M., &…”
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Temporal binding within and across events by DuBrow, Sarah, Davachi, Lila

“…•Serial recall transitions are reduced across context boundaries versus within events.•Hippocampus and vlPFC show activation at boundaries related to later…”
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Chronic stress, cognitive functioning and mental health by Marin, Marie-France, Lord, Catherine, Andrews, Julie, Juster, Robert-Paul, Sindi, Shireen, Arsenault-Lapierre, Geneviève, Fiocco, Alexandra J., Lupien, Sonia J.

“…► Chronic stress impacts cognition and increases vulnerability to mental illness. ► Findings have first emerged from the field of healthy and pathological…”
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Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases by Liang, Katharine J., Carlson, Erik S.

“…In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic markers of cellular aging in cerebellum accumulate more slowly than in the…”
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Rigor and reproducibility in rodent behavioral research by Gulinello, Maria, Mitchell, Heather A., Chang, Qiang, Timothy O'Brien, W., Zhou, Zhaolan, Abel, Ted, Wang, Li, Corbin, Joshua G., Veeraragavan, Surabi, Samaco, Rodney C., Andrews, Nick A., Fagiolini, Michela, Cole, Toby B., Burbacher, Thomas M., Crawley, Jacqueline N.

“…•Strategies to maximize rigor and reproducibility in rodent behavioral assays.•Replicability of translational rodent models as preclinical research tools.•Key…”
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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease by Ferreira, Sergio T., Klein, William L.

“…► Aβ oligomers comprise a variety species ranging from dimers to 12mers or higher. ► The molecular identity of the oligomer species that cause synapse failure…”
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Hydrogen sulfide slows down progression of experimental Alzheimer’s disease by targeting multiple pathophysiological mechanisms by Giuliani, Daniela, Ottani, Alessandra, Zaffe, Davide, Galantucci, Maria, Strinati, Flavio, Lodi, Renzo, Guarini, Salvatore

“…[Display omitted] •We found that hydrogen sulfide supply improves cognitive functions in three animal models of Alzheimer’s disease.•These effects are…”
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Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles by Dara, Tahereh, Vatanara, Alireza, Sharifzadeh, Mohammad, Khani, Samira, Vakilinezhad, Molood Alsadat, Vakhshiteh, Faezeh, Nabi Meybodi, Mohsen, Sadegh Malvajerd, Soroor, Hassani, Shokoufeh, Mosaddegh, Mohammad Hossein

“…•EPO could prevent Aβ1–42-induced impairment of spatial memory.•EPO reduced the oxidative stress, ADP/ATP ratio, and beta-amyloid plaque deposition in the…”
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Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats by Pietrelli, A., Matković, L., Vacotto, M., Lopez-Costa, J.J., Basso, N., Brusco, A.

“…[Display omitted] •Lifelong aerobic exercise mediated in the amplification of different memory systems.•Regular aerobic exercise upregulated the BDNF and 5-HT…”
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High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss by Duffy, C.M., Hofmeister, J.J., Nixon, J.P., Butterick, T.A.

“…•We tested interaction between diet and cognition in a mouse model of orexin loss.•Mice lacking orexin showed significant impairments in cognition vs…”
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From ventral-medial to dorsal-lateral striatum: Neural correlates of reward-guided decision-making by Burton, Amanda C., Nakamura, Kae, Roesch, Matthew R.

“…The striatum is critical for reward-guided and habitual behavior. Anatomical and interference studies suggest a functional heterogeneity within striatum…”
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Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research by Morris, Gary P., Clark, Ian A., Zinn, Raphael, Vissel, Bryce

“…•A next frontier in learning and memory research is understanding the role of non-neuronal cells at the synapse.•The term ‘resting’ to describe ramified…”
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Episodic future thinking and episodic counterfactual thinking: Intersections between memory and decisions by Schacter, Daniel L., Benoit, Roland G., De Brigard, Felipe, Szpunar, Karl K.

“…This article considers two recent lines of research concerned with the construction of imagined or simulated events that can provide insight into the…”
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