Search Results - "Neurobiology of aging"

Emerging roles of oxidative stress in brain aging and Alzheimer's disease by Ionescu-Tucker, Andra, Cotman, Carl W.

“…•Oxidative stress is involved in the progression of aging and Alzheimer's disease (AD).•Free radicals damage mitochondria, increasing production of toxic…”
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Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly by Cattaneo, Annamaria, PhD, Cattane, Nadia, PhD, Galluzzi, Samantha, MD, Provasi, Stefania, MSc, Lopizzo, Nicola, MSc, Festari, Cristina, MSc, Ferrari, Clarissa, PhD, Guerra, Ugo Paolo, MD, Paghera, Barbara, MD, Muscio, Cristina, MSc, Bianchetti, Angelo, MD, Volta, Giorgio Dalla, MD, Turla, Marinella, MD, Cotelli, Maria Sofia, MD, Gennuso, Michele, Prelle, Alessandro, MD, Zanetti, Orazio, MD, Lussignoli, Giulia, MD, Mirabile, Dario, MD, Bellandi, Daniele, MD, Gentile, Simona, Belotti, Gloria, MD, Villani, Daniele, MD, Harach, Taoufiq, MSc, Bolmont, Tristan, MD, Padovani, Alessandro, MD, Boccardi, Marina, PhD, Frisoni, Giovanni B., MD

“…Abstract The pathway leading from beta-amyloid deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer’s disease…”
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Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors by Cole, James H.

“…The brain-age paradigm is proving increasingly useful for exploring aging-related disease and can predict important future health outcomes. Most brain-age…”
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Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis by Falck, Ryan S., Davis, Jennifer C., Best, John R., Crockett, Rachel A., Liu-Ambrose, Teresa

“…Exercise plays a key role in healthy aging by promoting both physical and cognitive function. Physical function and cognitive function appear to be…”
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Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience by Stern, Yaakov, Barnes, Carol A., Grady, Cheryl, Jones, Richard N., Raz, Naftali

“…Significant individual differences in the trajectories of cognitive aging and in age-related changes of brain structure and function have been reported in the…”
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A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease by Chou, Ying-hui, Ton That, Viet, Sundman, Mark

“…Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive…”
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A framework for concepts of reserve and resilience in aging by Stern, Yaakov, Albert, Marilyn, Barnes, Carol A, Cabeza, Roberto, Pascual-Leone, Alvaro, Rapp, Peter R.

“…The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as…”
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What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons by Babiloni, Claudio, Blinowska, Katarzyna, Bonanni, Laura, Cichocki, Andrej, De Haan, Willem, Del Percio, Claudio, Dubois, Bruno, Escudero, Javier, Fernández, Alberto, Frisoni, Giovanni, Guntekin, Bahar, Hajos, Mihaly, Hampel, Harald, Ifeachor, Emmanuel, Kilborn, Kerry, Kumar, Sanjeev, Johnsen, Kristinn, Johannsson, Magnus, Jeong, Jaeseung, LeBeau, Fiona, Lizio, Roberta, Lopes da Silva, Fernando, Maestú, Fernando, McGeown, William J., McKeith, Ian, Moretti, Davide Vito, Nobili, Flavio, Olichney, John, Onofrj, Marco, Palop, Jorge J., Rowan, Michael, Stocchi, Fabrizio, Struzik, Zbigniew M, Tanila, Heikki, Teipel, Stefan, Taylor, John Paul, Weiergräber, Marco, Yener, Gorsev, Young-Pearse, Tracy, Drinkenburg, Wilhelmus H., Randall, Fiona

“…Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds)…”
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Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease: a pilot study by Neth, Bryan J., Mintz, Akiva, Whitlow, Christopher, Jung, Youngkyoo, Solingapuram Sai, Kiran, Register, Thomas C., Kellar, Derek, Lockhart, Samuel N., Hoscheidt, Siobhan, Maldjian, Joseph, Heslegrave, Amanda J., Blennow, Kaj, Cunnane, Stephen C., Castellano, Christian-Alexandre, Zetterberg, Henrik, Craft, Suzanne

“…There is currently no established therapy to treat or prevent Alzheimer’s disease. The ketogenic diet supplies an alternative cerebral metabolic fuel, with…”
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Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain by Shahidehpour, Ryan K., Higdon, Rebecca E., Crawford, Nicole G., Neltner, Janna H., Ighodaro, Eseosa T., Patel, Ela, Price, Douglas, Nelson, Peter T., Bachstetter, Adam D.

“…Loss of physiological microglial function may increase the propagation of neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we…”
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Disrupted structural and functional brain networks in Alzheimer's disease by Dai, Zhengjia, Lin, Qixiang, Li, Tao, Wang, Xiao, Yuan, Huishu, Yu, Xin, He, Yong, Wang, Huali

“…Studies have demonstrated that the clinical manifestations of Alzheimer's disease (AD) are associated with abnormal connections in either functional…”
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Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline by Taipa, Ricardo, das Neves, Sofia P., Sousa, Ana L., Fernandes, Joana, Pinto, Claudia, Correia, Ana P., Santos, Ernestina, Pinto, Pedro S., Carneiro, Paula, Costa, Patricio, Santos, Diana, Alonso, Isabel, Palha, Joana, Marques, Fernanda, Cavaco, Sara, Sousa, Nuno

“…Cumulative data suggest that neuroinflammation plays a prominent role in Alzheimer's disease (AD) pathogenesis. The purpose of this work was to assess if…”
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Physical activity, fitness, and gray matter volume by Erickson, Kirk I, Leckie, Regina L, Weinstein, Andrea M

“…Abstract In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on gray matter volume in older adults. We…”
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Sexual dimorphism in predisposition to Alzheimer's disease by Fisher, Daniel W., Bennett, David A., Dong, Hongxin

“…Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in both disease prevalence and rate of symptom progression, but the…”
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Apathy and anxiety are early markers of Alzheimer's disease by Johansson, Maurits, Stomrud, Erik, Lindberg, Olof, Westman, Eric, Johansson, Per Mårten, van Westen, Danielle, Mattsson, Niklas, Hansson, Oskar

“…In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter…”
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Age Differences in the Functional Interactions among the Default, Frontoparietal Control and Dorsal Attention Networks by Grady, Cheryl, Sarraf, Saman, Saverino, Cristina, Campbell, Karen

“…Abstract Older adults typically show weaker functional connectivity within brain networks compared to young adults, but stronger functional connections between…”
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A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology by Pasanen, Petra, Myllykangas, Liisa, Siitonen, Maija, Raunio, Anna, Kaakkola, Seppo, Lyytinen, Jukka, Tienari, Pentti J, Pöyhönen, Minna, Paetau, Anders

“…Abstract We describe the clinical, neuropathological, and genetic features of a Finnish patient with a novel α-synuclein ( SNCA ) mutation A53E. The patient…”
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Get a grip: individual variations in grip strength are a marker of brain health by Carson, Richard G.

“…Demonstrations that grip strength has predictive power in relation to a range of health conditions—even when these are assessed decades later—has motivated…”
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Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer’s disease by Yin, Zhuoran, Raj, Divya, Saiepour, Nasrin, Van Dam, Debby, Brouwer, Nieske, Holtman, Inge R, Eggen, Bart J.L, Möller, Thomas, Tamm, Joseph A, Abdourahman, Aicha, Hol, Elly M, Kamphuis, Willem, Bayer, Thomas A, De Deyn, Peter P, Boddeke, Erik

“…Abstract Alzheimer’s disease (AD) is strongly associated with microglia-induced neuroinflammation. Particularly, Aβ plaque-associated microglia take on an…”
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Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis by Karrer, Teresa M, Josef, Anika K, Mata, Rui, Morris, Evan D, Samanez-Larkin, Gregory R

“…Abstract Many theories of cognitive aging are based on evidence that dopamine (DA) declines with age. Here we performed a systematic meta-analysis of…”
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