Search Results - "Neumeyer, J. L."

A non-anhydrous, minimally basic protocol for the simplification of nucleophilic 18F-fluorination chemistry by Inkster, J. A. H., Akurathi, V., Sromek, A. W., Chen, Y., Neumeyer, J. L., Packard, A. B.

“…Fluorine-18 radiolabeling typically includes several conserved steps including elution of the [ 18 F]fluoride from an anion exchange cartridge with a basic…”
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Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane by Madras, B K, Spealman, R D, Fahey, M A, Neumeyer, J L, Saha, J K, Milius, R A

“…The potent cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)-tropane (CFT, also designated WIN 35,428) was tritiated and evaluated as a molecular…”
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Single Photon Emission Computed Tomographic Imaging Demonstrates Loss of Striatal Dopamine Transporters in Parkinson Disease by Innis, R. B., Seibyl, J. P., Scanley, B. E., Laruelle, M., Abi-Dargham, A., Wallace, E., Baldwin, R. M., Zea-Ponce, Y., Zoghbi, S., Wang, S., Gao, Y., Neumeyer, J. L., Charney, D. S., Hoffer, P. B., Marek, K. L.

“…[123][(1R)-2β-carbomethoxy-3β-(4-iodophenyl)tropane] ([k123I]β-CIT) labels dopamine transporters and is, therefore, a marker of neurons that degenerate in…”
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Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects by Laruelle, M, Wallace, E, Seibyl, J P, Baldwin, R M, Zea-Ponce, Y, Zoghbi, S S, Neumeyer, J L, Charney, D S, Hoffer, P B, Innis, R B

“…The in vivo kinetics of the dopamine (DA) transporter probe 123I-labeled 2 beta-carboxymethoxy-3 beta-(4-iodophenyl) tropane ([123I] beta-CIT) in striatum was…”
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SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of β-CIT by ABI-DARGHAM, A, GANDELMAN, M. S, INNIS, R. B, DEERAUSQUIN, G. A, ZEA-PONCE, Y, ZOGHBI, S. S, BALDWIN, R. M, LARUELLE, M, CHARNEY, D. S, HOFFER, P. B, NEUMEYER, J. L

“…Iodine-123-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) is a useful SPECT tracer for imaging the dopamine transporter. Its slow kinetics,…”
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Synthesis and Opioid Receptor Affinity of Morphinan and Benzomorphan Derivatives:  Mixed κ Agonists and μ Agonists/Antagonists as Potential Pharmacotherapeutics for Cocaine Dependence by Neumeyer, John L, Bidlack, Jean M, Zong, Rushi, Bakthavachalam, Venkatesalu, Gao, Peng, Cohen, Dana J, Negus, S. Stevens, Mello, Nancy K

“…This report concerns the synthesis and preliminary pharmacological evaluation of a novel series of κ agonists related to the morphinan (−)-cyclorphan (3a) and…”
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N-ω-Fluoroalkyl analogs of (1R)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane (β-CIT) : radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters by NEUMEYER, J. L, WANG, S, YIGONG GAO, MILIUS, R. A, KULA, N. S, CAMPBELL, A, BALDESSARINI, R. J, ZEA-PONCE, Y, BALDWIN, R. M, INNIS, R. B

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[ 3H]β-CIT: a radioligand for dopamine transporters in rat brain tissue by Kula, Nora S, Baldessarini, Ross J, Tarazi, Frank I, Fisser, Raoul, Wang, Shaoyin, Trometer, Joseph, Neumeyer, John L

“…[ 3H]2-β-carbomethoxy-3-β-[4′-iodophenyl]tropane (β-CIT) was prepared and evaluated. With rat forebrain tissue, [ 3H]β-CIT showed high affinity for dopamine…”
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Visualization of multiple imidazoline/guanidinium-receptive sites by LANIER, S. M, IVKOVIC, B, SINGH, I, NEUMEYER, J. L, VENKATESALU BAKTHAVACHALAM

“…Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many…”
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Radiosynthesis of [ 18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography by Chaly, Thomas, Dhawan, Vijay, Kazumata, Ken, Antonini, Angelo, Margouleff, Claude, Dahl, J.Robert, Belakhlef, Abdelfatihe, Margouleff, Donald, Yee, Archie, Wang, Shaoyin, Tamagnan, Gilles, Neumeyer, John L., Eidelberg, David

“…A procedure for the routine preparation of [ 18F]FP-CIT has been developed. Purification of the final product was achieved by preparative HPLC using phenethyl…”
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Simplified multidose preparation of iodine-123-β-CIT : a marker for dopamine transporters by ZEA-PONCE, Y, BALDWIN, R. M, LARUELLE, M, SHAOYIN WANG, NEUMEYER, J. L, INNIS, R. B

“…Iodine-123-beta-CIT is a SPECT radioligand for dopamine and 5-HT transporters with potential use in Parkinson's disease, schizophrenia and cocaine addiction…”
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Reproducibility of iodine-123-β-CIT SPECT brain measurement of dopamine transporters by SEIBYL, J. P, LARUELLE, M, INNIS, R. B, VAN DYCK, C. H, WALLACE, E, BALDWIN, R. M, ZOGHBI, S, ZEA-PONCE, Y, NEUMEYER, J. L, CHARNEY, D. S, HOFFER, P. B

“…Iodine-123-beta-CIT has been used as a probe of monoamine transporters in human and nonhuman primates utilizing SPECT. To assess the utility of this tracer for…”
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Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions by Laruelle, M, Giddings, S S, Zea-Ponce, Y, Charney, D S, Neumeyer, J L, Baldwin, R M, Innis, R B

“…Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate ([123I]beta-CIT) is a single photon emission computed tomographic radiotracer for in vivo labeling…”
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Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test by Reindl, J D, Rowan, K, Carey, A N, Peng, X, Neumeyer, J L, McLaughlin, J P

“…Previous studies have demonstrated that kappa opioid receptor (KOR) antagonists reduce stress- and depression-like behaviors. We hypothesized that…”
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[ O-methyl- 11C]β-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: Preparation, autoradiography, metabolite studies, and positron emission tomography examinations by Lundkvist, Camilla, Halldin, Christer, Swahn, Carl-Gunnar, Hall, Håkan, Karlsson, Per, Nakashima, Yoshifumi, Wang, Shaoyin, Milius, Richard A., Neumeyer, John L., Farde, Lars

“…β-CIT-FP [ N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane] is a cocaine analogue with a high affinity for the dopamine transporter. [ O-methyl-…”
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Synthesis and radiopharmacological characterization of 2β-carbo-2′-[ 18F]fluoroethoxy-3β-(4-bromo-phenyl)tropane ([ 18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT) by Wuest, F., Berndt, M., Strobel, K., van den Hoff, J., Peng, X., Neumeyer, J.L., Bergmann, R.

“…The simple single-step radiosynthesis and radiopharmacological characterization of [ 18F]MCL-322 as novel radiotracer for imaging DAT is described. The…”
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Further characterization of [3H]ifenprodil binding in rat brain by Hashimoto, K, Mantione, C R, Spada, M R, Neumeyer, J L, London, E D

“…The present study was undertaken to characterize [3H]ifenprodil binding in rat brain. [3H]Ifenprodil showed saturable, high-affinity binding at 4 degrees C…”
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Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain : autoradiographic assessment of D2-like and D3 sites by YEGHIAYAN, S. K, GONGWER, M. A, BALDESSARINI, R. J, KULA, N. S, ZONG, R, NEUMEYER, J. L

“…N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT), 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), or fluphenazine were…”
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[ 123I]IPCIT and [ 123I]β-CIT as SPECT tracers for the dopamine transporter : A comparative analysis in nonhuman primates by Scanley, B.E, Gandelman, M.S, Laruelle, M, Al-Tikriti, M.S, Baldwin, R.M, Zoghbi, S.S, Hoffer, P.B, Wang, S, Neumeyer, J.L, Innis, R.B

“…[ 123I]2β-Carbomethoxy-3β-(4-iodophenyl)tropane ([ 123I]β-CIT) and its isopropylester analog [ 123I]IPCIT, both of which are phenyltropane derivatives of…”
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Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects by Seibyl, J P, Wallace, E, Smith, E O, Stabin, M, Baldwin, R M, Zoghbi, S, Zea-Ponce, Y, Gao, Y, Zhang, W Y, Neumeyer, J L

“…SPECT imaging with 123I-labeled methyl 3 beta-(4-iodophenyl)tropane-2 beta-carboxylate ([123I]beta-CIT) in nonhuman primates has shown brain striatal activity,…”
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