Search Results - "Neumann, Jean‐Michel"

Class-B GPCR activation: is ligand helix-capping the key? by Neumann, Jean-Michel, Couvineau, Alain, Murail, Samuel, Lacapère, Jean-Jacques, Jamin, Nadège, Laburthe, Marc

“…The class B family of G-protein-coupled receptors (GPCRs) regulates essential physiological functions such as exocrine and endocrine secretions, feeding…”
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Characterization of the Cholesterol Recognition Amino Acid Consensus Sequence of the Peripheral-Type Benzodiazepine Receptor by Jamin, Nadège, Neumann, Jean-Michel, Ostuni, Mariano A, Vu, Thi Kim Ngoc, Yao, Zhi-Xing, Murail, Samuel, Robert, Jean-Claude, Giatzakis, Christoforos, Papadopoulos, Vassilios, Lacapère, Jean-Jacques

“…We previously defined a cholesterol recognition/interaction amino acid consensus sequence [CRAC: L/V–X (1–5)–Y–X (1–5)-R/K] in the carboxyl terminus of the…”
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Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction by Ceraudo, Emilie, Hierso, Régine, Tan, Yossan‐Var, Murail, Samuel, Rouyer‐Fessard, Christiane, Nicole, Pascal, Robert, Jean‐Claude, Jamin, Nadège, Neumann, Jean‐Michel, Robberecht, Patrick, Laburthe, Marc, Couvineau, Alain

“…Vasoactive intestinal peptide (VIP) plays a major role in pathophysiology. Our previous studies demonstrated that the VIP sequence 6‐28 interacts with the…”
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Structural Basis for the Interaction of Asf1 with Histone H3 and Its Functional Implications by Mousson, Florence, Lautrette, Aurélie, Thuret, Jean-Yves, Agez, Morgane, Courbeyrette, Régis, Amigues, Béatrice, Becker, Emmanuelle, Neumann, Jean-Michel, Guerois, Raphaël, Mann, Carl, Ochsenbein, Françoise, Felsenfeld, Gary

“…Asf1 is a conserved histone chaperone implicated in nucleosome assembly, transcriptional silencing, and the cellular response to DNA damage. We solved the NMR…”
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A New Consensus Sequence for Phosphatidylserine Recognition by Annexins by Montaville, Pierre, Neumann, Jean-Michel, Russo-Marie, Françoise, Ochsenbein, Françoise, Sanson, Alain

“…Annexins are abundant and ubiquitous proteins that bind, by their four structurally identical domain cores, to phosphatidylserine-containing membranes in the…”
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Determining membrane protein structures: still a challenge by Lacapère, Jean-Jacques, Pebay-Peyroula, Eva, Neumann, Jean-Michel, Etchebest, Catherine

“…Determination of structures and dynamics events of transmembrane proteins is important for the understanding of their function. Analysis of such events…”
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The human VPAC1 receptor: identification of the N-terminal ectodomain as a major VIP-binding site by photoaffinity labeling and 3D modeling by Couvineau, Alain, Tan, Yossan-Var, Ceraudo, Emille, Lacapère, Jean-Jacques, Murail, Samuel, Neumann, Jean-Michel, Laburthe, Marc

“…The human VPAC1 receptor for VIP and PACAP is a class II Gprotein-coupled receptor (GPCR). The N-terminal ectodomain of the VPAC1 receptor plays a crucial role…”
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Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding by Murail, Samuel, Robert, Jean-Claude, Coïc, Yves-Marie, Neumann, Jean-Michel, Ostuni, Mariano A., Yao, Zhin-Xing, Papadopoulos, Vassilios, Jamin, Nadège, Lacapère, Jean-Jacques

“…Numerous biological functions are attributed to the peripheral-type benzodiazepine receptor (PBR) recently renamed translocator protein (TSPO). The best…”
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Role of the membrane interface on the conformation of the caveolin scaffolding domain: A CD and NMR study by Lan, Charlotte Le, Neumann, Jean-Michel, Jamin, Nadège

“…Circular dichroism (CD) and NMR spectroscopy were used to study the conformational properties of two synthetic peptides, D82–R101 and D82–I109, encompassing…”
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The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics by Ceraudo, Emilie, Murail, Samuel, Tan, Yossan-Var, Lacapère, Jean-Jacques, Neumann, Jean-Michel, Couvineau, Alain, Laburthe, Marc

“…The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human pathophysiology and does so through interaction with class II G protein-coupled…”
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Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor: PHOTOAFFINITY, NMR, AND MOLECULAR MODELING by Tan, Yossan-Var, Couvineau, Alain, Murail, Samuel, Ceraudo, Emilie, Neumann, Jean-Michel, Lacapère, Jean-Jacques, Laburthe, Marc

“…The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human pathophysiology and does so through interaction with class II G protein-coupled…”
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ACTH binding to phospholipid bilayers: A 1H-NMR study of the 5-14, 1-14, and 1-24 derivatives by Roux, Michel, Neumann, Jean-Michel, Toma, Flavio

“…The interaction of the 5‐14, 1‐14, and 1‐24 fragments of ACTH with sonicated phospholipid bilayers containing egg yolk phosphatidylcholine (EPC) either pure or…”
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Dynamical characterization of residual and non-native structures in a partially folded protein by (15)N NMR relaxation using a model based on a distribution of correlation times by Ochsenbein, Françoise, Neumann, Jean-Michel, Guittet, Eric, van Heijenoort, Carine

“…A spectral density model based on a truncated lorentzian distribution of correlation times is used to analyze the nanosecond time-scale dynamics of the…”
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Slightly modifying pseudoproline dipeptides incorporation strategy enables solid phase synthesis of a 54 AA fragment of caveolin-1 encompassing the intramembrane domain by Coïc, Yves-Marie, Lan, Charlotte Le, Neumann, Jean-Michel, Jamin, Nadège, Baleux, Françoise

“…This work contributes to highlight the benefits of pseudoproline dipeptides introduction in difficult SPPS. We show how a slight modification in the…”
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The Human VPAC1 Receptor by COUVINEAU, ALAIN, TAN, YOSSAN-VAR, CERAUDO, EMILLE, LACAPÈRE, JEAN-JACQUES, MURAIL, SAMUEL, NEUMANN, JEAN-MICHEL, LABURTHE, MARC

“…:  The human VPAC1 receptor for VIP and PACAP is a class II Gprotein–coupled receptor (GPCR).The N‐terminal ectodomain of the VPAC1 receptor plays a crucial…”
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Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor by Tan, Yossan-Var, Couvineau, Alain, Murail, Samuel, Ceraudo, Emilie, Neumann, Jean-Michel, Lacapère, Jean-Jacques, Laburthe, Marc

“…The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human pathophysiology and does so through interaction with class II G protein-coupled…”
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Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant β-sheet structure by Jamin, Nadège, Coı̈c, Yves-Marie, Landon, Céline, Ovtracht, Ludmila, Baleux, Françoise, Neumann, Jean-Michel, Sanson, Alain

“…The conversion of the cellular prion protein into the β-sheet-rich scrapie prion protein is thought to be the key step in the pathogenesis of prion diseases…”
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Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues by Coïc, Yves-Marie, Vincent, Michel, Gallay, Jacques, Baleux, Françoise, Mousson, Florence, Beswick, Veronica, Neumann, Jean-Michel, de Foresta, Béatrice

“…Membrane protein insertion in the lipid bilayer is determining for their activity and is governed by various factors such as specific sequence motifs or key…”
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Deciphering the Role of Individual Acyl Chains in the Interaction Network between Phosphatidylserines and a Single-Spanning Membrane Protein by Mousson, Florence, Coïc, Yves-Marie, Baleux, Françoise, Beswick, Veronica, Sanson, Alain, Neumann, Jean-Michel

“…PMP1 is a small single-spanning membrane protein functioning as a regulatory subunit of the yeast plasma membrane H+-ATPase. This protein forms a unique helix…”
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Dynamical characterization of residual and non‐native structures in a partially folded protein by 15N NMR relaxation using a model based on a distribution of correlation times by Ochsenbein, Françoise, Neumann, Jean‐Michel, Guittet, Eric, Van Heijenoort, Carine

“…A spectral density model based on a truncated lorentzian distribution of correlation times is used to analyze the nanosecond time‐scale dynamics of the…”
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