Search Results - "Neumann, Detlef"

The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut by Schirmer, Bastian, Neumann, Detlef

“…Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds…”
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Probiotics in Naunyn–Schmiedeberg’s Archives of Pharmacology by Neumann, Detlef, Seifert, Roland

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Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice by SCHNEIDER, Erich H, NEUMANN, Detlef, SEIFERT, Roland

“…Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate the immune system, but is also acting as a neurotransmitter…”
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Interleukin‐4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma‐bearing mice by Costamagna, Domiziana, Duelen, Robin, Penna, Fabio, Neumann, Detlef, Costelli, Paola, Sampaolesi, Maurilio

“…Background Anorexia, body wasting, inflammation, muscle, and adipose tissue loss are hallmarks of cancer cachexia, a syndrome that affects the majority of…”
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Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice by SCHNEIDER, Erich H, NEUMANN, Detlef, SEIFERT, Roland

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Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis by Schirmer, Bastian, Rezniczek, Thomas, Seifert, Roland, Neumann, Detlef

“…[Display omitted] Millions of people worldwide are suffering from inflammatory bowel disease (IBD), which severely affects patients’ life qualities and even…”
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Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice by Schirmer, Bastian, Wedekind, Dirk, Glage, Silke, Neumann, Detlef

“…The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop…”
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In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice by Schirmer, Bastian, Bringmann, Luisa, Seifert, Roland, Neumann, Detlef

“…Our previous in vitro studies revealed that histamine via histamine the H4-receptors (H4R), as compared to other stimuli, such as eotaxin or formylpeptides,…”
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An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells by Kyriazi, Despoina, Voth, Lea, Bader, Almke, Ewert, Wiebke, Gerlach, Juliane, Elfrink, Kerstin, Franz, Peter, Tsap, Mariana I., Schirmer, Bastian, Damiano-Guercio, Julia, Hartmann, Falk K., Plenge, Masina, Salari, Azam, Schöttelndreier, Dennis, Strienke, Katharina, Bresch, Nadine, Salinas, Claudio, Gutzeit, Herwig O., Schaumann, Nora, Hussein, Kais, Bähre, Heike, Brüsch, Inga, Claus, Peter, Neumann, Detlef, Taft, Manuel H., Shcherbata, Halyna R., Ngezahayo, Anaclet, Bähler, Martin, Amiri, Mahdi, Knölker, Hans-Joachim, Preller, Matthias, Tsiavaliaris, Georgios

“…Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of…”
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Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity by Seifert, Roland, Schneider, Erich H, Dove, Stefan, Brunskole, Irena, Neumann, Detlef, Strasser, Andrea, Buschauer, Armin

“…The histamine H(4) receptor (H(4)R) is expressed in several cell types of the immune system and is assumed to play an important pro-inflammatory role in…”
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Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation by Beermann, Silke, Glage, Silke, Jonigk, Danny, Seifert, Roland, Neumann, Detlef

“…Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an…”
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Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells by Beermann, Silke, Vauth, Marcus, Hein, Rabea, Seifert, Roland, Neumann, Detlef

“…Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R…”
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Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice by Wunschel, Eva J., Schirmer, Bastian, Seifert, Roland, Neumann, Detlef

“…Inflammatory bowel diseases (IBD) are a growing health problem worldwide, severely affecting patients’ life qualities and life expectancies. Therapeutic…”
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Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor by Deml, Karl-Friedrich, Beermann, Silke, Neumann, Detlef, Strasser, Andrea, Seifert, Roland

“…The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of…”
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Strain‐specific colitis susceptibility in IL10‐deficient mice depends on complex gut microbiota–host interactions by Büchler, Gwen, Wos‐Oxley, Melissa L., Smoczek, Anna, Zschemisch, Nils‐H., Neumann, Detlef, Pieper, Dietmar H., Hedrich, Hans J., Bleich, Andre

“…Background: Colitis susceptibility in Il10−/− mice depends on genetic background and microbiota composition. A major genetic locus mediating colitis…”
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Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation by Mahapatra, Subhashree, Albrecht, Melanie, Behrens, Barbara, Jirmo, Adan, Behrens, Georg, Hartwig, Christina, Neumann, Detlef, Raap, Ulrike, Bähre, Heike, Herrick, Christina, Dittrich, Anna-Maria

“…Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is…”
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IL-18 Activity in Systemic Lupus Erythematosus by Favilli, Flavia, Anzilotti, Consuelo, Martinelli, Lucia, Quattroni, Paola, De Martino, Salvatore, Pratesi, Federico, Neumann, Detlef, Beermann, Silke, Novick, Daniela, Dinarello, Charles A., Boraschi, Diana, Migliorini, Paola

“…Interleukin‐18 (IL‐18) is an inflammation‐related cytokine that plays a central role both in innate defense reactions and in Th1 activation and specific immune…”
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Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling by Kollewe, Christian, Mackensen, Anne-Christin, Neumann, Detlef, Knop, Johannes, Cao, Ping, Li, Shyun, Wesche, Holger, Martin, Michael U.

“…The interleukin-1 receptor-associated kinase 1 (IRAK-1) is an important adapter in the signaling complex of the Toll/interleukin-1 (IL-1) receptor family…”
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Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma? by Neumann, Detlef, Beermann, Silke, Seifert, Roland

“…The histamine H4 receptor is expressed preferentially on immune cells, indicating a possible role of the H4 receptor in inflammation. Studies of inflammation…”
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Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c by Zimmermann, Anna Sophie, Burhenne, Heike, Kaever, Volkhard, Seifert, Roland, Neumann, Detlef

“…Objective Histamine plays a role in several (patho) physiological processes that are commonly studied in mouse models. However, a systematic quantification of…”
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