Search Results - "Neuman, Keir C"

propagating ATPase gradient drives transport of surface-confined cellular cargo by Vecchiarelli, Anthony G., Neuman, Keir C., Mizuuchi, Kiyoshi

“…The faithful segregation of duplicated genetic material into daughter cells is critical to all organisms. In many bacteria, the segregation of chromosomes…”
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Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD by Vecchiarelli, Anthony G., Li, Min, Mizuuchi, Michiyo, Hwang, Ling Chin, Seol, Yeonee, Neuman, Keir C., Mizuuchi, Kiyoshi

“…The Escherichia coli Min system self-organizes into a cell-pole to cell-pole oscillator on the membrane to prevent divisions at the cell poles. Reconstituting…”
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Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism by Sarkar, Susanta K., Marmer, Barry, Goldberg, Gregory, Neuman, Keir C.

“…Collagen, the most abundant human protein, is the principal component of the extracellular matrix and plays important roles in maintaining tissue and organ…”
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Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β by Yang, Xi, Saha, Sourav, Yang, Wei, Neuman, Keir C., Pommier, Yves

“…In metazoans, topoisomerase 3β (TOP3B) regulates R-loop dynamics and mRNA translation, which are critical for genome stability, neurodevelopment and normal…”
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Direct observation of topoisomerase IA gate dynamics by Mills, Maria, Tse-Dinh, Yuk-Ching, Neuman, Keir C.

“…Type IA topoisomerases cleave single-stranded DNA and relieve negative supercoils in discrete steps corresponding to the passage of the intact DNA strand…”
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Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids by Hu, Longhua, Vecchiarelli, Anthony G., Mizuuchi, Kiyoshi, Neuman, Keir C., Liu, Jian

“…Bacterial plasmids are extrachromosomal DNA that provides selective advantages for bacterial survival. Plasmid partitioning can be remarkably robust. For…”
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Polydopamine Encapsulation of Fluorescent Nanodiamonds for Biomedical Applications by Jung, Hak‐Sung, Cho, Kyung‐Jin, Seol, Yeonee, Takagi, Yasuharu, Dittmore, Andrew, Roche, Paul A., Neuman, Keir C.

“…Fluorescent nanodiamonds (FNDs) are promising bioimaging probes compared with other fluorescent nanomaterials such as quantum dots, dye‐doped nanoparticles,…”
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UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency by Chapman, Joseph H, Youle, Alice M, Grimme, Acadia L, Neuman, Keir C, Hogg, J Robert

“…The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and…”
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Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases by Jian, Jeffrey Y, McCarty, Kevin D, Byl, Jo Ann W, Guengerich, F Peter, Neuman, Keir C, Osheroff, Neil

“…Abstract To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this…”
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Silica Encapsulation of Fluorescent Nanodiamonds for Colloidal Stability and Facile Surface Functionalization by Bumb, Ambika, Sarkar, Susanta K, Billington, Neil, Brechbiel, Martin W, Neuman, Keir C

“…Fluorescent nanodiamonds (FNDs) emit in the near-IR and do not photobleach or photoblink. These properties make FNDs better suited for numerous imaging…”
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Activities of gyrase and topoisomerase IV on positively supercoiled DNA by Ashley, Rachel E, Dittmore, Andrew, McPherson, Sylvia A, Turnbough, Jr, Charles L, Neuman, Keir C, Osheroff, Neil

“…Although bacterial gyrase and topoisomerase IV have critical interactions with positively supercoiled DNA, little is known about the actions of these enzymes…”
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Directed and persistent movement arises from mechanochemistry of the ParA/ParB system by Hu, Longhua, Vecchiarelli, Anthony G., Mizuuchi, Kiyoshi, Neuman, Keir C., Liu, Jian

“…The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves…”
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Surface Modification of Fluorescent Nanodiamonds for Biological Applications by Jung, Hak-Sung, Neuman, Keir C

“…Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging,…”
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Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq by Morgan, Ian L, McKie, Shannon J, Kim, Rachel, Seol, Yeonee, Xu, Jing, Harami, Gabor M, Maxwell, Anthony, Neuman, Keir C

“…Abstract Type II topoisomerases (topos) are a ubiquitous and essential class of enzymes that form transient enzyme-bound double-stranded breaks on DNA called…”
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UPF1 mutants with intact ATPase but deficient helicase activities promote efficient nonsense-mediated mRNA decay by Chapman, Joseph H, Craig, Jonathan M, Wang, Clara D, Gundlach, Jens H, Neuman, Keir C, Hogg, J Robert

“…The conserved RNA helicase UPF1 coordinates nonsense-mediated mRNA decay (NMD) by engaging with mRNAs, RNA decay machinery and the terminating ribosome. UPF1…”
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CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning by Taylor, James A, Seol, Yeonee, Budhathoki, Jagat, Neuman, Keir C, Mizuuchi, Kiyoshi

“…ParABS partition systems, comprising the centromere-like DNA sequence parS , the parS -binding ParB-CTPase, and the nucleoid-binding ParA-ATPase, ensure…”
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Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion by Craig, Jonathan M, Mills, Maria, Kim, Hwanhee C, Huang, Jesse R, Abell, Sarah J, Mount, Jonathan W, Gundlach, Jens H, Neuman, Keir C, Laszlo, Andrew H

“…Helicases are essential for nearly all nucleic acid processes across the tree of life, yet detailed understanding of how they couple ATP hydrolysis to…”
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The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops by Harami, Gábor M., Pálinkás, János, Seol, Yeonee, Kovács, Zoltán J., Gyimesi, Máté, Harami-Papp, Hajnalka, Neuman, Keir C., Kovács, Mihály

“…Homologous recombination (HR) is a ubiquitous and efficient process that serves the repair of severe forms of DNA damage and the generation of genetic…”
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General Method to Increase Carboxylic Acid Content on Nanodiamonds by Shenoy, Ganesh, Ettedgui, Jessica, Mushti, Chandrasekhar, Hong, Jennifer, Lane, Kelly, Blackman, Burchelle, Jung, Hak-Sung, Takagi, Yasuharu, Seol, Yeonee, Brechbiel, Martin, Swenson, Rolf E, Neuman, Keir C

“…Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation…”
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Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy by Melters, Daniël P, Neuman, Keir C, Bentahar, Reda S, Rakshit, Tatini, Dalal, Yamini

“…Chromatin accessibility is modulated in a variety of ways to create open and closed chromatin states, both of which are critical for eukaryotic gene…”
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