HAART and the liver: friend or foe?

The overall effect of HAART on the liver is the result of the balance between hepatotoxicity and the consequences of immunoreconstitution on the evolution of HIV-associated liver diseases, particularly viral hepatitis. HAART may lead to the emergence of acute toxic hepatitis, steatosis, steatohepati...

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Bibliographic Details
Published in:	European journal of medical research Vol. 15; no. 3; p. 93
Main Authors:	Pineda, J A, Macías, J, Mira, J A, Merchante, N, del Valle, J, Neukam, K I
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 30-03-2010 BioMed Central BMC
Subjects:	Antiretroviral Therapy, Highly Active Chemical and Drug Induced Liver Injury - etiology Complications and side effects Development and progression Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Highly active antiretroviral therapy HIV (Viruses) HIV Infections - complications HIV Infections - drug therapy Humans Liver - drug effects Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver diseases Prognosis Review Risk factors
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Summary:	The overall effect of HAART on the liver is the result of the balance between hepatotoxicity and the consequences of immunoreconstitution on the evolution of HIV-associated liver diseases, particularly viral hepatitis. HAART may lead to the emergence of acute toxic hepatitis, steatosis, steatohepatitis, liver fibrosis, and noncirrhotic portal hypertension. On the other hand, HAART use has been associated with slower fibrosis progression in HIV/HCV-coinfected patients in most studies dealing with this issue. As well, an improvement of the clinical outcome of liver disease has been reported in patients taking HAART. For these reasons, the short- and mid-term effects of HAART on the liver are mostly beneficial.
ISSN:	0949-2321 2047-783X 2047-783X
DOI:	10.1186/2047-783x-15-3-93