Search Results - "Neuhoff, S."

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine by Jamei, M., Bajot, F., Neuhoff, S., Barter, Z., Yang, J., Rostami-Hodjegan, A., Rowland-Yeo, K.

“…Background and Objectives The interplay between liver metabolising enzymes and transporters is a complex process involving system-related parameters such as…”
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Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model by Darwich, A S, Neuhoff, S, Jamei, M, Rostami-Hodjegan, A

“…Bioavailability of orally administered drugs can be influenced by a number of factors including release from the formulation, dissolution, stability in the…”
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Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions by Burt, H.J., Neuhoff, S., Almond, L., Gaohua, L., Harwood, M.D., Jamei, M., Rostami-Hodjegan, A., Tucker, G.T., Rowland-Yeo, K.

“…Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs with new chemical entities. The aim of the current study was to…”
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Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis by Burt, Howard J, Riedmaier, Arian Emami, Harwood, Matthew D, Crewe, H Kim, Gill, Katherine L, Neuhoff, Sibylle

“…This study aimed to derive quantitative abundance values for key hepatic transporters suitable for in vitro-in vivo extrapolation within a physiologically…”
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Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption by Harwood, M. D., Neuhoff, S., Carlson, G. L., Warhurst, G., Rostami-Hodjegan, A.

“…ABSTRACT The use of whole body physiological‐based pharmacokinetic (PBPK) models linked with in vitro‐in vivo extrapolation (IVIVE) of kinetic parameters from…”
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In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells by Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey

“…Over the last 5 years the quantification of transporter-protein absolute abundances has dramatically increased in parallel to the expanded use of in vitro-in…”
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In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition by Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

“…Relative expression factors (REFs) are used to scale in vitro transporter kinetic data via in vitro-in vivo extrapolation linked to physiologically based…”
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Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1‐Related Variability in Pharmacodynamics of Rosuvastatin by Rose, RH, Neuhoff, S, Abduljalil, K, Chetty, M, Rostami‐Hodjegan, A, Jamei, M

“…Typically, pharmacokinetic–pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability…”
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Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter by Emoto, C, Fukuda, T, Johnson, TN, Neuhoff, S, Sadhasivam, S, Vinks, AA

“…Morphine shows large interindividual variability in its pharmacokinetics; however, the cause of this has not been fully addressed. The variability in morphine…”
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Initiation of Clement Surface Conditions on the Earliest Earth by Sleep, N. H., Zahnle, K., Neuhoff, P. S.

“…In the beginning the surface of the Earth was extremely hot, because the Earth as we know it is the product of a collision between two planets, a collision…”
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Low-temperature hydrothermal metamorphic mineralization of island-arc volcanics, South Apuseni Mountains, Romania by Miron, George Dan, Neuhoff, Philip S, Amthauer, Georg

“…The island-arc volcanics situated in the eastern part of the Capilnas-Techereu nappe (South Apuseni Mountains, Romania) were studied to evaluate the…”
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Impact of extracellular protein binding on passive and active drug transport across caco-2 cells by NEUHOFF, Sibylle, ANURSSON, Per, ZAMORA, Ismael, UNGELL, Anna-Lena

“…The objective of the study is to evaluate the mechanism behind alterations in passive and active transport of drugs in the presence of basolaterally applied…”
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Mechanisms and geochemical significance of Si–Al substitution in zeolite solid solutions by Neuhoff, Philip S., Ruhl, Laura S.

“…Rock-forming zeolites often exhibit complex solid solutions reflecting isomorphous substitutions between Si and Al in tetrahedral framework sites, between…”
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Enhanced resolution and quantitation from `ultrahigh' field NMR spectroscopy of glasses by Kroeker, Scott, Neuhoff, Philip S., Stebbins, Jonathan F.

“…The utilization of higher magnetic fields for nuclear magnetic resonance (NMR) (e.g., 14.1 and 18.8 T) can enhance both resolution and sensitivity in studies…”
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Conduit enlargement in an eogenetic karst aquifer by Moore, Paul J., Martin, Jonathan B., Screaton, Elizabeth J., Neuhoff, Philip S.

“…Most concepts of conduit development have focused on telogenetic karst aquifers, where low matrix permeability focuses flow and dissolution along joints,…”
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Pyroclastic deposits within the East Greenland Tertiary flood basalts by Heister, L. E, O'Day, P. A, Brooks, C. K, Neuhoff, P. S, Bird, D. K

“…Stratigraphic, geochemical and mineralogical characterization of pyroclastic deposits on the Gronau West Nunatak of East Greenland indicates that both alkaline…”
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Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers by Neuhoff, S., Artursson, P., Ungell, A.-L.

“…The effects of Cremophor EL (CEL) and bovine serum albumin (BSA) on the active and passive permeation of BCS class II compounds (felodipine, asimadoline) were…”
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Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites by Neuhoff, S, Langguth, P, Dressler, C, Andersson, T B, Regårdh, C G, Spahn-Langguth, H

“…The multidrug transporter P-glycoprotein (P-gp) appears to play a significant role in drug absorption and disposition. Hence, it is of interest to evaluate…”
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Zeolite Parageneses in the North Atlantic Igneous Province: Implications for Geotectonics and Groundwater Quality of Basaltic Crust by Neuhoff, Philip S., Fridriksson, Thráinn, Bird, Dennis K.

“…Zeolites are among the most common products of chemical interaction between groundwaters and the Earth's crust during diagenesis and low-grade metamorphism…”
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A solid solution model for Si–Al substitution in disordered FAU and LTA zeolites by Neuhoff, Philip S., Stebbins, Jonathan F.

“…Configurational entropies ( S con) arising from disordering of Si and Al in the frameworks of FAU and LTA zeolites were calculated from published 29 Si MAS NMR…”
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