Search Results - "Neuhaus, Eva M."

Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes by Gelis, Lian, Jovancevic, Nikolina, Veitinger, Sophie, Mandal, Bhubaneswar, Arndt, Hans-Dieter, Neuhaus, Eva M., Hatt, Hanns

“…Olfactory receptors, which belong to the family of G-protein-coupled receptors, are found to be ectopically expressed in non-sensory tissues mediating a…”
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Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells by Neuhaus, Eva M., Zhang, Weiyi, Gelis, Lian, Deng, Ying, Noldus, Joachim, Hatt, Hanns

“…Olfactory receptors (ORs) are expressed not only in the sensory neurons of the olfactory epithelium, where they detect volatile substances, but also in various…”
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Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis by Gelis, Lian, Jovancevic, Nikolina, Bechara, Falk G., Neuhaus, Eva M., Hatt, Hanns

“…We identified the olfactory receptor 51E2 in human melanoma and have measured both OR51E2 mRNA and protein expression in melanoma tissue sections. qPCR…”
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Deep sequencing of the murine olfactory receptor neuron transcriptome by Kanageswaran, Ninthujah, Demond, Marilen, Nagel, Maximilian, Schreiner, Benjamin S P, Baumgart, Sabrina, Scholz, Paul, Altmüller, Janine, Becker, Christian, Doerner, Julia F, Conrad, Heike, Oberland, Sonja, Wetzel, Christian H, Neuhaus, Eva M, Hatt, Hanns, Gisselmann, Günter

“…The ability of animals to sense and differentiate among thousands of odorants relies on a large set of olfactory receptors (OR) and a multitude of accessory…”
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An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase by Pelz, Thomas, Drose, Daniela R, Fleck, David, Henkel, Bastian, Ackels, Tobias, Spehr, Marc, Neuhaus, Eva M

“…TMEM16 proteins are a recently identified protein family comprising Ca2+-activated Cl- channels that generate outwardly rectifying ionic currents in response…”
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Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models by Kurtenbach, Stefan, Wewering, Sonja, Hatt, Hanns, Neuhaus, Eva M, Lübbert, Hermann

“…Various genetic or toxin-induced mouse models are frequently used for investigation of early PD pathology. Although olfactory impairment is known to precede…”
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The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila by Deng, Ying, Zhang, Weiyi, Farhat, Katja, Oberland, Sonja, Gisselmann, Günter, Neuhaus, Eva M

“…Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant receptors have seven…”
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Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster by Neuhaus, Eva M, Gisselmann, Günter, Zhang, Weiyi, Dooley, Ruth, Störtkuhl, Klemens, Hatt, Hanns

“…Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the largest subfamily, odorant…”
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Co-expression of anoctamins in cilia of olfactory sensory neurons by Henkel, Bastian, Drose, Daniela R, Ackels, Tobias, Oberland, Sonja, Spehr, Marc, Neuhaus, Eva M

“…Vertebrates can sense and identify a vast array of chemical cues. The molecular machinery involved in chemodetection and transduction is expressed within the…”
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The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia by Kurtenbach, Stefan, Gießl, Andreas, Strömberg, Siv, Kremers, Jan, Atorf, Jenny, Rasche, Sebastian, Neuhaus, Eva M., Hervé, Denis, Brandstätter, Johann Helmut, Asan, Esther, Hatt, Hanns, Kilimann, Manfred W.

“…BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA…”
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CD36 is involved in oleic acid detection by the murine olfactory system by Oberland, Sonja, Ackels, Tobias, Gaab, Stefanie, Pelz, Thomas, Spehr, Jennifer, Spehr, Marc, Neuhaus, Eva M

“…Olfactory signals influence food intake in a variety of species. To maximize the chances of finding a source of calories, an animal's preference for fatty…”
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Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons by Untiet, Verena, Moeller, Lisa M, Ibarra-Soria, Ximena, Sánchez-Andrade, Gabriela, Stricker, Miriam, Neuhaus, Eva M, Logan, Darren W, Gensch, Thomas, Spehr, Marc

“…In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ…”
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Particulate Adenylate Cyclase Plays a Key Role in Human Sperm Olfactory Receptor-mediated Chemotaxis by Spehr, Marc, Schwane, Katlen, Riffell, Jeffrey A., Barbour, Jon, Zimmer, Richard K., Neuhaus, Eva M., Hatt, Hanns

“…Human sperm chemotaxis is a critical component of the fertilization process, but the molecular basis for this behavior remains unclear. Recent evidence shows…”
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Molecular evolution of a chordate specific family of G protein-coupled receptors by Kurtenbach, Stefan, Mayer, Christoph, Pelz, Thomas, Hatt, Hanns, Leese, Florian, Neuhaus, Eva M

“…Chordate evolution is a history of innovations that is marked by physical and behavioral specializations, which led to the development of a variety of forms…”
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ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa by Dietz, André, Senf, Katja, Neuhaus, Eva M.

“…Barrier‐forming olfactory glia cells, termed sustentacular cells, play important roles for immune defense of the olfactory mucosa, for example as entry sites…”
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Purinergic receptor antagonists inhibit odorant-mediated CREB phosphorylation in sustentacular cells of mouse olfactory epithelium by Dooley, Ruth, Mashukova, Anastasia, Toetter, Bastian, Hatt, Hanns, Neuhaus, Eva M

“…Extracellular nucleotides have long been known to play neuromodulatory roles and to be involved in intercellular signalling. In the olfactory system, ATP is…”
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Chemokine signaling is required for homeostatic and injury‐induced neurogenesis in the olfactory epithelium by Senf, Katja, Karius, Julia, Stumm, Ralf, Neuhaus, Eva M.

“…The olfactory epithelium (OE) possesses unique lifelong neuroregenerative capacities and undergoes constitutive neurogenesis throughout mammalian lifespan. Two…”
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Prediction of a Ligand-Binding Niche within a Human Olfactory Receptor by Combining Site-Directed Mutagenesis with Dynamic Homology Modeling by Gelis, Lian, Wolf, Steffen, Hatt, Hanns, Neuhaus, Eva M., Gerwert, Klaus

“…Reprogramming a smell receptor: The ligand‐binding niche within a three‐dimensional model of a human olfactory receptor has been predicted by dynamic homology…”
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A Myosin I Is Involved in Membrane Recycling from Early Endosomes by Neuhaus, Eva M., Soldati, Thierry

“…Geometry-based mechanisms have been proposed to account for the sorting of membranes and fluid phase in the endocytic pathway, yet little is known about the…”
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The Stimulatory Gαs Protein Is Involved in Olfactory Signal Transduction in Drosophila by Deng, Ying, Zhang, Weiyi, Farhat, Katja, Oberland, Sonja, Gisselmann, Günter, Neuhaus, Eva M.

“…Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant receptors have seven…”
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