Search Results - "Neugebauer, Sophie"

Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients by Schmerler, Diana, Neugebauer, Sophie, Ludewig, Katrin, Bremer-Streck, Sibylle, Brunkhorst, Frank Martin, Kiehntopf, Michael

“…The occurrence of systemic inflammatory response syndrome (SIRS) remains a major problem in intensive care units with high morbidity and mortality. The…”
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Simultaneous Quantification of Nine Antimicrobials by LC-MS/MS for Therapeutic Drug Monitoring in Critically Ill Patients by Neugebauer, Sophie, Wichmann, Christina, Bremer-Streck, Sibylle, Hagel, Stefan, Kiehntopf, Michael

“…Adequate antibiotic treatment is a prerequisite for the successful treatment of systemic infections. Based on accumulating scientific evidence, a fixed dosage…”
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RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis by Hoff, Jessica, Xiong, Ling, Kammann, Tobias, Neugebauer, Sophie, Micheel, Julia M., Gaßler, Nikolaus, Bauer, Michael, Press, Adrian T.

“…Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various liver…”
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk by Leonhardt, Julia, Dorresteijn, Mirrin J, Neugebauer, Sophie, Mihaylov, Diana, Kunze, Julia, Rubio, Ignacio, Hohberger, Frank-Stephan, Leonhardt, Silke, Kiehntopf, Michael, Stahl, Klaus, Bode, Christian, David, Sascha, Wagener, Frank A D T G, Pickkers, Peter, Bauer, Michael

“…Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying…”
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Quantification of Bile Acids in Cerebrospinal Fluid: Results of an Observational Trial by Harnisch, Lars-Olav, Neugebauer, Sophie, Mihaylov, Diana, Eidizadeh, Abass, Zechmeister, Bozena, Maier, Ilko, Moerer, Onnen

“…(1) Background: Bile acids, known as aids in intestinal fat digestion and as messenger molecules in serum, can be detected in cerebrospinal fluid (CSF),…”
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Transfer of FRozen Encapsulated multi-donor Stool filtrate for active ulcerative Colitis (FRESCO): study protocol for a prospective, multicenter, double-blind, randomized, controlled trial by Stallmach, Andreas, Grunert, Philip, Stallhofer, Johannes, Löffler, Bettina, Baier, Michael, Rödel, Jürgen, Kiehntopf, Michael, Neugebauer, Sophie, Pieper, Dietmar H, Junca, Howard, Tannapfel, Andrea, Merkel, Ute, Schumacher, Ulrike, Breternitz-Gruhne, Maria, Heller, Tabitha, Schauer, Anja, Hartmann, Michael, Steube, Arndt

“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease with significant morbidity and mortality. Although the precise cause remains unknown,…”
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Serum Metabolome Signatures Characterizing Co-Infection of Plasmodium falciparum and HBV in Pregnant Women by Asantewaa, Gloria, Godwin Anabire, Nsoh, Bauer, Michael, Weis, Sebastian, Neugebauer, Sophie, Quaye, Osbourne, Helegbe, Gideon Kofi

“…( ) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with either of these two pathogens results…”
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Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors by Khaliq, Waqas, Großmann, Peter, Neugebauer, Sophie, Kleyman, Anna, Domizi, Roberta, Calcinaro, Sara, Brealey, David, Gräler, Markus, Kiehntopf, Michael, Schäuble, Sascha, Singer, Mervyn, Panagiotou, Gianni, Bauer, Michael

“…[Display omitted] Sepsis remains a major cause of death despite advances in medical care. Metabolic deregulation is an important component of the survival…”
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Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease by Dellbrügge, Friederike, Jesse, Lena D., Medyukhina, Anna, Liu, Na, Neugebauer, Sophie, Freißmuth, Markus, Höppener, Stephanie, Figge, Marc T., Morrison, Helen, Riecken, Lars B., Press, Adrian T.

“…Excretory liver failure is frequently associated with poor prognosis in critically ill patients. It is characterized by the loss of canalicular membrane export…”
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Physical Exercise Induces Specific Adaptations Resulting in Reduced Organ Injury and Mortality During Severe Polymicrobial Sepsis by Sossdorf, Maik, Fischer, Jacqueline, Meyer, Stefan, Dahlke, Katja, Wissuwa, Bianka, Seidel, Carolin, Schrepper, Andrea, Bockmeyer, Clemens L., Lupp, Amelie, Neugebauer, Sophie, Schmerler, Diana, Rödel, Jürgen, Claus, Ralf A., Otto, Gordon P.

“…OBJECTIVES:High physical activity levels are associated with wide-ranging health benefits, disease prevention, and longevity. In the present study, we examined…”
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Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker by Bekfani, Tarek, Bekhite, Mohamed, Neugebauer, Sophie, Derlien, Steffen, Hamadanchi, Ali, Nisser, Jenny, Hilse, Marion S, Haase, Daniela, Kretzschmar, Tom, Wu, Mei-Fang, Lichtenauer, Michael, Kiehntopf, Michael, von Haehling, Stephan, Schlattmann, Peter, Lehmann, Gabriele, Franz, Marcus, Möbius-Winkler, Sven, Schulze, Christian

“…Aims: Metabolic and structural perturbations in skeletal muscle have been found in patients with heart failure (HF) both with preserved (HFpEF) and reduced…”
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Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation by Hilse, Marion S., Kretzschmar, Tom, Pistulli, Rudin, Franz, Marcus, Bekfani, Tarek, Haase, Daniela, Neugebauer, Sophie, Kiehntopf, Michael, Gummert, Jan F., Milting, Hendrik, Schulze, P. Christian

“…Chronic heart failure (HF) is a clinical syndrome characterized by functional impairments of the myocardium. Metabolic and clinical changes develop with…”
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Mo1792 ENRICHMENT OF 3β-HYDROXYSTEROID DEHYDROGENASE CARRYING BACTERIA IN CROHN'S DISEASE WITH RUMINOCOCCUS GNAVUS AS MOST ABUNDANT STRAIN by Stallhofer, Johannes, Semmler, Juliane, Neugebauer, Sophie, Ungelenk, Martin, Huebner, Christian, Stallmach, Andreas, Waschina, Silvio

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Metabolite Profiles in Sepsis: Developing Prognostic Tools Based on the Type of Infection by Neugebauer, Sophie, Giamarellos-Bourboulis, Evangelos J., Pelekanou, Aimilia, Marioli, Androniki, Baziaka, Fotini, Tsangaris, Iraklis, Bauer, Michael, Kiehntopf, Michael

“…OBJECTIVES:Currently used biomarkers insufficiently discriminate between patients with systemic inflammatory response syndrome of non-infectious origin and…”
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Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial by Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, Hohn, Andreas, Weigand, Markus, Michels, Guido, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, König, Christina, Weismann, Dirk, Frey, Otto, Witzke, Dominic, Müller, Carsten, Bauer, Michael, Kiehntopf, Michael, Neugebauer, Sophie, Lehmann, Thomas, Roberts, Jason A., Pletz, Mathias W.

“…Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided…”
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Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis by Sommerfeld, Oliver, Medyukhina, Anna, Neugebauer, Sophie, Ghait, Mohamed, Ulferts, Svenja, Lupp, Amelie, König, Rainer, Wetzker, Reinhard, Schulz, Stefan, Figge, Marc Thilo, Bauer, Michael, Press, Adrian T.

“…Complement factor C5a was originally identified as a powerful promoter of inflammation through activation of the C5a receptor 1 (C5ar1). Recent evidence…”
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Introduction of BD Vacutainer ® Barricor™ tubes in clinical biobanking and application of amino acid and cytokine quality indicators to Barricor plasma by Knutti, Nadine, Neugebauer, Sophie, Scherr, Franziska, Mathay, Conny, Marchese, Monica, Henry, Estelle, Palm, Julia, Betsou, Fay, Kiehntopf, Michael

“…The use of BD Vacutainer Barricor™ tubes (BAR) can reduce turnaround time (TAT) and improve separation of plasma from cellular components using a specific…”
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Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction by Kretzschmar, Tom, Westphal, Julian, Neugebauer, Sophie, Wu, Jasmine M F, Zeller, Max, Bogoviku, Jurgen, Bekhite, Mohamed M, Bekfani, Tarek, Schlattmann, Peter, Kiehntopf, Michael, Franz, Marcus, Schulze, P Christian

“…Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. It has the potential to improve the diagnosis and…”
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Serum Metabolome Signatures Characterizing Co-Infection of IPlasmodium falciparum/I and HBV in Pregnant Women by Asantewaa, Gloria, Anabire, Nsoh Godwin, Bauer, Michael, Weis, Sebastian, Neugebauer, Sophie, Quaye, Osbourne, Helegbe, Gideon Kofi

“…Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with…”
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Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology by Falk, Julia, Rohde, Magdalena, Bekhite, Mohamed M., Neugebauer, Sophie, Hemmerich, Peter, Kiehntopf, Michael, Deufel, Thomas, Hübner, Christian A., Beetz, Christian

“…ABSTRACT Hereditary axonopathies are frequently caused by mutations in proteins that reside in the endoplasmic reticulum (ER). Which of the many ER functions…”
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