Search Results - "Neugebauer, Karla"

Nascent RNA and the Coordination of Splicing with Transcription by Neugebauer, Karla M

“…At each active protein-encoding gene, nascent RNA is tethered to the DNA axis by elongating RNA polymerase II (Pol II) and is continuously altered by splicing…”
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How cell biology can save the planet by Neugebauer, Karla M.

“…Climate change affects us all, and tackling it requires a concerted effort, but it isn’t always evident how cell biologists’ work can impact climate change…”
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Droplet organelles? by Courchaine, Edward M, Lu, Alice, Neugebauer, Karla M

“…Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by lipid bilayers. These compartments are implicated in a wide range…”
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How cells get the message: dynamic assembly and function of mRNA–protein complexes by Müller-McNicoll, Michaela, Neugebauer, Karla M.

“…Key Points Global approaches are defining the full complement of proteins with RNA-binding capacity in living cells. RNA packaging by proteins begins during…”
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Transcription Regulation Through Nascent RNA Folding by Schärfen, Leonard, Neugebauer, Karla M.

“…[Display omitted] •Nascent RNA starts folding as soon as it exits RNA polymerase.•Transcription kinetics modulate the folding pathway.•RNA Structures close to…”
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Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II by Carrillo Oesterreich, Fernando, Herzel, Lydia, Straube, Korinna, Hujer, Katja, Howard, Jonathon, Neugebauer, Karla M.

“…Protein-coding genes in eukaryotes are transcribed by RNA polymerase II (Pol II) and introns are removed from pre-mRNA by the spliceosome. Understanding the…”
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Splicing and transcription touch base: co-transcriptional spliceosome assembly and function by Herzel, Lydia, Ottoz, Diana S. M., Alpert, Tara, Neugebauer, Karla M.

“…Key Points Splicing mainly takes place during transcription. Catalysis is achieved through the stepwise assembly of the spliceosome onto nascent RNA. Recent in…”
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Splicing under stress: A matter of time and place by Podszywalow-Bartnicka, Paulina, Neugebauer, Karla M

“…Excision of introns during splicing regulates gene expression. In this issue, work by Sung et al. (https://doi.org/10.1083/jcb.202111151) demonstrates that the…”
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Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling by Rodenfels, Jonathan, Neugebauer, Karla M., Howard, Jonathon

“…All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic…”
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Long-read sequencing of nascent RNA reveals coupling among RNA processing events by Herzel, Lydia, Straube, Korinna, Neugebauer, Karla M

“…Pre-mRNA splicing is accomplished by the spliceosome, a megadalton complex that assembles de novo on each intron. Because spliceosome assembly and catalysis…”
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Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis by Reimer, Kirsten A., Mimoso, Claudia A., Adelman, Karen, Neugebauer, Karla M.

“…Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with…”
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The promoter as a trip navigator: Guiding alternative polyadenylation site destinations by Bergfort, Alexandra, Neugebauer, Karla M.

“…Alfonso-Gonzalez et al.1 present an innovative combination of long-read-sequencing approaches that reveal coupling of alternative transcription start sites and…”
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RNA tales - how embryos read and discard messages from mom by Despic, Vladimir, Neugebauer, Karla M

“…Following fertilization, embryos develop for a substantial amount of time with a transcriptionally silent genome. Thus, early development is maternally…”
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Uncoupling of nucleo-cytoplasmic RNA export and localization during stress by Hochberg-Laufer, Hodaya, Schwed-Gross, Avital, Neugebauer, Karla M, Shav-Tal, Yaron

“…Abstract Eukaryotic cells contain sub-cellular compartments that are not membrane bound. Some structures are always present, such as nuclear speckles that…”
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Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA by Draycott, Austin S, Schaening-Burgos, Cassandra, Rojas-Duran, Maria F, Wilson, Loren, Schärfen, Leonard, Neugebauer, Karla M, Nachtergaele, Sigrid, Gilbert, Wendy V

“…Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete dihydrouridine landscape is unknown in any organism. We introduce…”
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Multiple roles for AU-rich RNA binding proteins in the development of haematologic malignancies and their resistance to chemotherapy by Podszywalow-Bartnicka, Paulina, Neugebauer, Karla M

“…Post-transcriptional regulation by RNA binding proteins can determine gene expression levels and drive changes in cancer cell proteomes. Identifying mechanisms…”
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RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes by Änkö, Minna-Liisa, Müller-McNicoll, Michaela, Brandl, Holger, Curk, Tomaz, Gorup, Crtomir, Henry, Ian, Ule, Jernej, Neugebauer, Karla M

“…BACKGROUND: The SR proteins comprise a family of essential, structurally related RNA binding proteins. The complexity of their RNA targets and specificity of…”
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The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing by Brody, Yehuda, Neufeld, Noa, Bieberstein, Nicole, Causse, Sebastien Z, Böhnlein, Eva-Maria, Neugebauer, Karla M, Darzacq, Xavier, Shav-Tal, Yaron

“…RNA processing events that take place on the transcribed pre-mRNA include capping, splicing, editing, 3' processing, and polyadenylation. Most of these…”
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Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing by Carrocci, Tucker J, Neugebauer, Karla M

“…Proper gene expression requires the collaborative effort of multiple macromolecular machines to produce functional messenger RNA. As RNA polymerase II (RNA Pol…”
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Perfect timing: splicing and transcription rates in living cells by Alpert, Tara, Herzel, Lydia, Neugebauer, Karla M.

“…An important step toward understanding gene regulation is the elucidation of the time necessary for the completion of individual steps. Measurement of reaction…”
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