Search Results - "Neufeld, Megan"

Immobilization of Metal–Organic Framework Copper(II) Benzene-1,3,5-tricarboxylate (CuBTC) onto Cotton Fabric as a Nitric Oxide Release Catalyst by Neufeld, Megan J, Harding, Jacqueline L, Reynolds, Melissa M

“…Immobilization of metal–organic frameworks (MOFs) onto flexible polymeric substrates as secondary supports expands the versatility of MOFs for surface coatings…”
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High‐Z Metal–Organic Frameworks for X‐ray Radiation‐Based Cancer Theranostics by Neufeld, Megan J., Lutzke, Alec, Pratx, Guillem, Sun, Conroy

“…X‐ray radiation is commonly employed in clinical practice for diagnostic and therapeutic applications. Over the past decade, developments in nanotechnology…”
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The quest for blood-compatible materials: Recent advances and future technologies by Hedayati, Mohammadhasan, Neufeld, Megan J., Reynolds, Melissa M., Kipper, Matt J.

“…The development of blood-compatible materials represents a grand challenge in biomaterials science. Blood is a complex fluid containing many types of living…”
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Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa by Neufeld, Bella H., Neufeld, Megan J., Lutzke, Alec, Schweickart, Sarah M., Reynolds, Melissa M.

“…An 85% reduction in the bacterial attachment of Pseudomonas aeruginosa is achieved using a water‐stable metal–organic framework (MOF) blended with chitosan…”
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Metal–Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S‑Nitrosoglutathione in Aqueous Solution by Neufeld, Megan J, Lutzke, Alec, Tapia, Jesus B, Reynolds, Melissa M

“…It has been previously demonstrated that copper-based metal–organic frameworks (MOFs) accelerate formation of the therapeutically active molecule nitric oxide…”
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Lanthanide Metal-Organic Frameworks for Multispectral Radioluminescent Imaging by Neufeld, Megan J, Winter, Hayden, Landry, Madeleine R, Goforth, Andrea M, Khan, Syamantak, Pratx, Guillem, Sun, Conroy

“…In this report, we describe the X-ray luminescent properties of two lanthanide-based nanoscale metal-frameworks (nMOFs) and their potential as novel platforms…”
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Nitric Oxide Generation from Endogenous Substrates Using Metal–Organic Frameworks: Inclusion within Poly(vinyl alcohol) Membranes To Investigate Reactivity and Therapeutic Potential by Neufeld, Megan J, Lutzke, Alec, Jones, W. Matthew, Reynolds, Melissa M

“…Cu-BTTri (H3BTTri = 1,3,5-tris­[1H-1,2,3-triazol-5-yl]­benzene) is a water-stable, copper-based metal–organic framework (MOF) that exhibits the ability to…”
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Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer by DuRoss, Allison N., Landry, Madeleine R., Thomas, Charles R., Neufeld, Megan J., Sun, Conroy

“…Colorectal cancer (CRC) is a leading cause of cancer-related death for both men and women, highlighting the need for new treatment strategies. Advanced disease…”
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Integrating nanomedicine into clinical radiotherapy regimens by DuRoss, Allison N., Neufeld, Megan J., Rana, Shushan, Thomas, Charles R., Sun, Conroy

“…While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational…”
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Sustained Nitric Oxide Release from a Tertiary S‑Nitrosothiol-based Polyphosphazene Coating by Lutzke, Alec, Tapia, Jesus B, Neufeld, Megan J, Reynolds, Melissa M

“…Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing…”
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Water-Stable Metal–Organic Framework/Polymer Composites Compatible with Human Hepatocytes by Neufeld, Megan J, Ware, Brenton R, Lutzke, Alec, Khetani, Salman R, Reynolds, Melissa M

“…Metal–organic frameworks (MOFs) have demonstrated promise in biomedical applications as vehicles for drug delivery, as well as for the ability of copper-based…”
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Co-delivery of PARP and PI3K inhibitors by nanoscale metal–organic frameworks for enhanced tumor chemoradiation by Neufeld, Megan J., DuRoss, Allison N., Landry, Madeleine R., Winter, Hayden, Goforth, Andrea M., Sun, Conroy

“…Due to their complementary activity, the use of DNA damage repair (DDR) inhibitors during radiotherapy (RT) has yielded promising results. Unfortunately, this…”
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Nitric oxide generation from S-nitrosoglutathione: New activity of indium and a survey of metal ion effects by Lutzke, Alec, Melvin, Alyssa C., Neufeld, Megan J., Allison, Christopher L., Reynolds, Melissa M.

“…S-Nitrosothiols (RSNOs) such as S-nitrosoglutathione (GSNO) are known to produce nitric oxide (NO) through thermal, photolytic, and metal ion-promoted…”
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The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples by Penner-Goeke, Signe, Lichtensztejn, Zelda, Neufeld, Megan, Ali, Jennifer L, Altman, Alon D, Nachtigal, Mark W, McManus, Kirk J

“…Epithelial ovarian cancer (EOC) is the most prevalent form of ovarian cancer and has the highest mortality rate. Novel insight into EOC is required to minimize…”
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Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy by DuRoss, Allison N, Neufeld, Megan J, Landry, Madeleine R, Rosch, Justin G, Eaton, Colin T, Sahay, Gaurav, Thomas, Charles R, Sun, Conroy

“…Chemoradiation is an effective combined modality therapeutic approach that utilizes principles of spatial cooperation to combat the adaptability associated…”
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A metal organic framework reduces thrombus formation and platelet aggregation ex vivo by Roberts, Teryn R, Neufeld, Megan J, Meledeo, Michael A, Cap, Andrew P, Cancio, Leopoldo C, Reynolds, Melissa M, Batchinsky, Andriy I

“…Management of hemostasis is a key challenge during extracorporeal life support (ECLS). Metal organic frameworks are being investigated for use as nitric oxide…”
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Antibacterial Surfaces: Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa (Adv. Funct. Mater. 34/2017) by Neufeld, Bella H., Neufeld, Megan J., Lutzke, Alec, Schweickart, Sarah M., Reynolds, Melissa M.

“…This image represents the impediment of bacterial attachment onto the materials described by Melissa M. Reynolds and co‐workers in article number 1702255…”
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Preclinical data on co-delivery of temozolomide and talazoparib by fucodain-coated nanoscale metal organic frameworks for colorectal cancer chemoradiation by DuRoss, Allison N., Landry, Madeleine R., Thomas, Charles R., Neufeld, Megan J., Sun, Conroy

“…Nanoparticle characterization and in vitro data on the effects of combined PARP inhibition and DNA damage by chemoradiation are shown. This data accompanies…”
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Synthesis of Radioluminescent CaF2:Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics by Winter, Hayden, Neufeld, Megan J., Makotamo, Lydia, Sun, Conroy, Goforth, Andrea M.

“…X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious…”
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Nanoscale Hafnium Metal–Organic Frameworks Enhance Radiotherapeutic Effects by Upregulation of Type I Interferon and TLR7 Expression by Choi, Eunseo, Landry, Madeleine, Pennock, Nathan, Neufeld, Megan, Weinfurter, Katherine, Goforth, Andrea, Walker, Joshua, Sun, Conroy

“…Recent preclinical and clinical studies have highlighted the improved outcomes of combination radiotherapy and immunotherapy. Concurrently, the development of…”
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