Search Results - "Neufeld, Gera"

Class-3 Semaphorins and Their Receptors: Potent Multifunctional Modulators of Tumor Progression by Toledano, Shira, Nir-Zvi, Inbal, Engelman, Rotem, Kessler, Ofra, Neufeld, Gera

“…bstract: Semaphorins are the products of a large gene family containing 28 genes of which 21 are found in vertebrates. Class-3 semaphorins constitute a…”
Get full text

Lysyl Oxidase Family Enzymes and Their Role in Tumor Progression by Liburkin-Dan, Tanya, Toledano, Shira, Neufeld, Gera

“…The five genes of the lysyl oxidase family encode enzymes that covalently cross-link components of the extracellular matrix, such as various types of collagen…”
Get full text

Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling by Kigel, Boaz, Rabinowicz, Noa, Varshavsky, Asya, Kessler, Ofra, Neufeld, Gera

“…Plexin-A4 is a receptor for sema6A and sema6B and associates with neuropilins to transduce signals of class-3 semaphorins. We observed that plexin-A1 and…”
Get full text

Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins by Smolkin, Tatyana, Nir-Zvi, Inbal, Duvshani, Nerri, Mumblat, Yelena, Kessler, Ofra, Neufeld, Gera

“…Class-3 semaphorin guidance factors bind to receptor complexes containing neuropilin and plexin receptors. A semaphorin may bind to several receptor complexes…”
Get full text

Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment by Smith, Victoria, Barry-Hamilton, Vivian, Spangler, Rhyannon, Marshall, Derek, McCauley, Scott, Rodriguez, Hector M, Oyasu, Miho, Mikels, Amanda, Vaysberg, Maria, Ghermazien, Haben, Wai, Carol, Garcia, Carlos A, Velayo, Arleene C, Jorgensen, Brett, Biermann, Donna, Tsai, Daniel, Green, Jennifer, Zaffryar-Eilot, Shelly, Holzer, Alison, Ogg, Scott, Thai, Dung, Neufeld, Gera, Van Vlasselaer, Peter

“…Pathologically altered stromas are a common contributing factor to cancer progression and fibrogenesis. This report uncovers the role of LOXL2 in the creation…”
Get full text

Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells by Kigel, Boaz, Varshavsky, Asya, Kessler, Ofra, Neufeld, Gera

“…The class-3 semaphorins (sema3s) include seven family members. Six of them bind to neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the…”
Get full text

Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes by Liburkin-Dan, Tatyana, Nir-Zvi, Inbal, Razon, Hila, Kessler, Ofra, Neufeld, Gera

“…The five lysyl-oxidase genes share similar enzymatic activities and contribute to tumor progression. We have knocked out the five lysyl-oxidase genes in…”
Get full text

A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion by Brekhman, Vera, Neufeld, Gera

“…The induction of tumor cell invasion is an important step in tumor progression. Due to the cost and slowness of in-vivo invasion assays, there is need for…”
Get full text

Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells by Toledano, Shira, Sabag, Adi D., Ilan, Neta, Liburkin-Dan, Tanya, Kessler, Ofra, Neufeld, Gera

“…The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of…”
Get full text

Semaphorin-3A and Semaphorin-3F Work Together to Repel Endothelial Cells and to Inhibit Their Survival by Induction of Apoptosis by Guttmann-Raviv, Noga, Shraga-Heled, Niva, Varshavsky, Asya, Guimaraes-Sternberg, Cinthya, Kessler, Ofra, Neufeld, Gera

“…Semaphorin-3A (sema3A) is a neuropilin-1 (np1) agonist. It inhibits the binding of the 165-amino acid form of VEGF (VEGF165) to np1 and was reported to inhibit…”
Get full text

Semaphorin 3A Is Effective in Reducing Both Inflammation and Angiogenesis in a Mouse Model of Bronchial Asthma by Adi, Sabag D, Eiza, Nasren, Bejar, Jacob, Shefer, Hila, Toledano, Shira, Kessler, Ofra, Neufeld, Gera, Toubi, Elias, Vadasz, Zahava

“…Semaphorin 3A (sema3A) belongs to the sub-family of the immune semaphorins that function as regulators of immune-mediated inflammation. Sema3A is a membrane…”
Get full text

Truncated-semaphorin3A is a potential regulatory molecule to restore immune homeostasis in immune-mediated diseases by Eiza, Nasren, Kessler, Ofra, Sabag, Adi, Neufeld, Gera, Jones, E Yvonne, Vadasz, Zahava

“…Regulatory molecules have recently been recognized for their beneficial effects in the treatment of immune-mediated diseases, rather than using cytotoxic…”
Get full text

Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion by Kraft-Sheleg, Ortal, Zaffryar-Eilot, Shelly, Genin, Olga, Yaseen, Wesal, Soueid-Baumgarten, Sharon, Kessler, Ofra, Smolkin, Tatyana, Akiri, Gal, Neufeld, Gera, Cinnamon, Yuval, Hasson, Peleg

“…For muscles to function, myofibers have to stretch and anchor at the myotendinous junction (MTJ), a region rich in extracellular matrix (ECM). Integrin…”
Get full text

The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain by Vo, Tam, Carulli, Daniela, Ehlert, Erich M.E., Kwok, Jessica C.F., Dick, Gunnar, Mecollari, Vasil, Moloney, Elizabeth B., Neufeld, Gera, de Winter, Fred, Fawcett, James W., Verhaagen, Joost

“…In the adult rodent brain, subsets of neurons are surrounded by densely organised extracellular matrix called perineuronal nets (PNNs). PNNs consist of…”
Get full text

Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain by Sabag, Adi D, Bode, Julia, Fink, Dorit, Kigel, Boaz, Kugler, Wilfried, Neufeld, Gera

“…Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To…”
Get full text

Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus by Vadasz, Zahava, Haj, Tharwat, Halasz, Katalin, Rosner, Itzhak, Slobodin, Gleb, Attias, Dina, Kessel, Aharon, Kessler, Ofra, Neufeld, Gera, Toubi, Elias

“…Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced…”
Get full text

Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres by Perets, Anat, Baruch, Yaacov, Weisbuch, Felix, Shoshany, Gideon, Neufeld, Gera, Cohen, Smadar

“…Site‐specific delivery of angiogenic growth factors from tissue‐engineered devices should provide an efficient means of stimulating localized vessel…”
Get full text

LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression by Jiao, Ji-Wei, Zhan, Xiu-Hui, Wang, Juan-Juan, He, Li-Xia, Guo, Zhen-Chang, Xu, Xiu-E, Liao, Lian-Di, Huang, Xin, Wen, Bing, Xu, Yi-Wei, Hu, Hai, Neufeld, Gera, Chang, Zhi-Jie, Zhang, Kai, Xu, Li-Yan, Li, En-Min

“…Lysyl-oxidase like-2 (LOXL2) regulates extracellular matrix remodeling and promotes tumor invasion and metastasis. Altered metabolism is a core hallmark of…”
Get full text

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1 by Prahst, Claudia, Héroult, Mélanie, Lanahan, Anthony A., Uziel, Noa, Kessler, Ofra, Shraga-Heled, Niva, Simons, Michael, Neufeld, Gera, Augustin, Hellmut G.

“…Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the angiogenic cascade by interacting with its high affinity VEGF receptors…”
Get full text

A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization by Toledano, Shira, Lu, Huayi, Palacio, Agustina, Ziv, Keren, Kessler, Ofra, Schaal, Shlomit, Neufeld, Gera, Barak, Yoreh

“…In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated…”
Get full text