Search Results - "Neuenschwander, Kent"

RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase by Amin, D, Rutledge, R Z, Needle, S N, Galczenski, H F, Neuenschwander, K, Scotese, A C, Maguire, M P, Bush, R C, Hele, D J, Bilder, G E, Perrone, M H

“…Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl pyrophosphate to form squalene and is the first committed step in sterol…”
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Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

“…One common synthetic route creates small‐molecule libraries directed toward two functionally distinct target families. The novel structural template 1 can…”
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Design and synthesis of D1 agonist/D2 antagonist for treatment of schizophrenia by Giovanni, Andrew, Roehr, Joachim, Dwyer, Shannon, Neuenschwander, Kent, Scotese, Anthony, Moorcroft, Neil D., Davis, Larry, Gao, Zhongli

“…A series of tetrahydroisoquinolines were designed, synthesized and evaluated as the first non-natural product type of compounds with dual D1 receptor (D1R)…”
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Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation by Hopkins, Corey, Neuenschwander, Kent, Scotese, Anthony, Jackson, Sharon, Nieduzak, Thaddeus, Pauls, Henry, Liang, Guyan, Sides, Keith, Cramer, Dona, Cairns, Jennifer, Maignan, Sebastien, Mathieu, Magali

“…[Display omitted] In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization…”
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Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template by Groneberg, Robert D, Burns, Christopher J, Morrissette, Matthew M, Ullrich, John W, Morris, Robert L, Darnbrough, Shelley, Djuric, Stevan W, Condon, Stephen M, McGeehan, Gerard M, Labaudiniere, Richard, Neuenschwander, Kent, Scotese, Anthony C, Kline, Jane A

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Quaternary Ammonium Salts as Chromophores for Exciton-Coupled Circular Dichroism: Absolute Configuration of Hypocholesterolemic Quinuclidines by Zhao, Ning, Kumar, Narendra, Neuenschwander, Kent, Nakanishi, Koji, Berova, Nina

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Facile synthesis of N-acyl-2-pyrrolines by Kraus, George A, Neuenschwander, Kent

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THE SYNTHESIS OF PYRROLIZIDINE ALKALOIDS by NEUENSCHWANDER, KENT WILLIAM

“…The pyrrolizidine alkaloids constitute an exceptionally large class of naturally occurring compounds. A number of the alkaloids are hepatotoxic and…”
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Conversion of lactones into ethers by Kraus, George A, Frazier, Kevin A, Roth, Bruce D, Taschner, Michael J, Neuenschwander, Kent

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Synthese von Inhibitoren für zwei Familien biologischer Targets in einer Sequenz: ein nächster Schritt beim Aufbau kombinatorischer Bibliotheken? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

“…Über nureinen Syntheseweg lassen sich Bibliotheken aus niedermolekularen Verbindungen aufbauen, die auf zwei Targetfamilien mit unterschiedlichen…”
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RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent by Amin, D, Gustafson, S K, Weinacht, J M, Cornell, S A, Neuenschwander, K, Kosmider, B, Scotese, A C, Regan, J R, Perrone, M H

“…RG 12561 (dalvastatin) is a prodrug which converts to its open hydroxyacid form in the body. The Na salt of RG 12561 (RG 12561-Na) is a potent inhibitor of…”
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Metal atom reactions with fluorocarbons. 9. Preparation and spectral analyses of (perfluoroalkyl)- and (perfluoroaryl)palladium halides by Klabunde, Kenneth J, Anderson, Bruce B, Neuenschwander, Kent

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Synthese von Inhibitoren für zwei Familien biologischer Targets in einer Sequenz: ein nächster Schritt beim Aufbau kombinatorischer Bibliotheken? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

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