Search Results - "Neubert, Alan D"

Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans by Nakajima, Katsumasa, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Coppola, Gary M, Daniels, Thomas, Forster, Cornelia J, Gilmore, Thomas A, Gong, Yongjin, Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, Meyers, Charles D, Neubert, Alan D, Szklennik, Paul, Tedesco, Vivienne, Thompson, James, Truong, David, Yang, Qing, Hubbard, Brian K, Serrano-Wu, Michael H

“…Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include…”
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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme by Wallace, Eli M, Moliterni, John A, Moskal, Michael A, Neubert, Alan D, Marcopulos, Nicholas, Stamford, Lisa B, Trapani, Angelo J, Savage, Paula, Chou, Mary, Jeng, Arco Y

“…Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion…”
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Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides by Serrano-Wu, Michael H, Coppola, Gary M, Gong, Yongjin, Neubert, Alan D, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K

“…High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which…”
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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

“…High-throughput screening identified 5 as a weak inhibitor of 11β-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some with…”
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Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine by Yokoyama, Naokata, Walker, Gordon N, Main, Alan J, Stanton, James L, Morrissey, Michael M, Boehm, Charles, Engle, Allan, Neubert, Alan D, Wasvary, Jong M

“…Aryloxamic acids 7 and 23, (arylamino)acetic acids 29, arylpropionic acids 33, arylthioacetic acids 37, and (aryloxy)acetic acid 41 related to…”
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Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E

“…High-throughput screening identified 5 as a weak inhibitor of 11beta-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some…”
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2-Arylpyrazolo[4,3-c]quinolin-3-ones: a novel agonist, a partial agonist and an antagonist of benzodiazepines by Yokoyama, Naokata, Ritter, Barry, Neubert, Alan D.

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2-arylpyrazolo(4,3-c)quinolin-3-ones: Novel agonist, partial agonist, and antagonist of benzodiazepines by Yokoyama, N, Ritter, B, Neubert, AD

“…The authors wish to report on three novel 2-arylpyrazolo(4,3-c)quinolin-3-ones, all of which possess extremely high affinity for the benzodiazepine receptors,…”
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