Search Results - "Neuberger, Michael S"

Molecular mechanisms of antibody somatic hypermutation by Di Noia, Javier M, Neuberger, Michael S

“…Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation…”
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Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice by Kemmerich, Kristin, Dingler, Felix A, Rada, Cristina, Neuberger, Michael S

“…Deamination of cytosine (C), 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) occurs spontaneously in mammalian DNA with several hundred deaminations…”
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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis by Taylor, Benjamin Jm, Nik-Zainal, Serena, Wu, Yee Ling, Stebbings, Lucy A, Raine, Keiran, Campbell, Peter J, Rada, Cristina, Stratton, Michael R, Neuberger, Michael S

“…Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several…”
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Antibody diversification by somatic mutation: from Burnet onwards by Neuberger, Michael S

“…The clonal selection theory proposed by Burnet required a genetic process, for which there was then no precedent, which randomizes the region of the gene(s)…”
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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID by Wang, Meng, Rada, Cristina, Neuberger, Michael S

“…High-affinity antibodies are generated by somatic hypermutation with nucleotide substitutions introduced into the IgV in a semirandom fashion, but with…”
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The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice by Xue, Kanmin, Rada, Cristina, Neuberger, Michael S

“…Immunoglobulin (Ig) class switching is initiated by deamination of C-->U within the immunoglobulin heavy chain locus, catalyzed by activation-induced deaminase…”
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Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A) by Häsler, Julien, Rada, Cristina, Neuberger, Michael S

“…Activation-induced cytidine deaminase (AID) is a B lymphocyte-specific DNA deaminase that acts on the Ig loci to trigger antibody gene diversification. Most…”
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stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence by Geisberger, Roland, Rada, Cristina, Neuberger, Michael S

“…The carboxyterminal region of activation-induced deaminase (AID) is required for its function in Ig class switch recombination (CSR) and also contains a…”
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Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy by Sato, Yusuke, Probst, Hans Christian, Tatsumi, Ryuichi, Ikeuchi, Yoshihide, Neuberger, Michael S., Rada, Cristina

“…The apoB RNA-editing enzyme, catalytic polypeptide-like (APOBEC) family of proteins includes APOBEC1, APOBEC3, and activation-induced deaminase, all of which…”
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Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases by Conticello, Silvestro G, Thomas, Cornelia J F, Petersen-Mahrt, Svend K, Neuberger, Michael S

“…The AID/APOBEC family (comprising AID, APOBEC1, APOBEC2, and APOBEC3 subgroups) contains members that can deaminate cytidine in RNA and/or DNA and exhibit…”
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DNA Deamination Mediates Innate Immunity to Retroviral Infection by Harris, Reuben S, Bishop, Kate N, Sheehy, Ann M, Craig, Heather M, Petersen-Mahrt, Svend K, Watt, Ian N, Neuberger, Michael S, Malim, Michael H

“…CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV)…”
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Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1 by Conticello, Silvestro G., Ganesh, Karuna, Xue, Kanmin, Lu, Mason, Rada, Cristina, Neuberger, Michael S.

“…Activation-induced deaminase (AID) deaminates deoxycytidine residues in immunoglobulin genes, triggering antibody diversification. Here, by use of two-hybrid…”
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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase by Neuberger, Michael S, Di Noia, Javier

“…A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region (IgV) genes are diversified…”
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AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity by Neuberger, Michael S, Wang, Meng, Yang, Zizhen, Rada, Cristina

“…AID is a DNA cytidine deaminase that participates in the generation of antibody diversity. AID's mutagenic activity is carefully controlled by transcriptional…”
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The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G by Conticello, Silvestro G, Harris, Reuben S, Neuberger, Michael S

“…APOBEC3G is a human cellular enzyme that is incorporated into retroviral particles and acts to restrict retroviral replication in infected cells by deaminating…”
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Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo by Takeda, Eri, Tsuji-Kawahara, Sachiyo, Sakamoto, Mayumi, Langlois, Marc-André, Neuberger, Michael S., Rada, Cristina, Miyazawa, Masaaki

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The AKV Murine Leukemia Virus Is Restricted and Hypermutated by Mouse APOBEC3 by LANGLOIS, Marc-André, KEMMERICH, Kristin, RADA, Cristina, NEUBERGER, Michael S

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The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification by Ganesh, Karuna, Neuberger, Michael S.

“…ABSTRACT The origin of antibody diversity has intrigued scientists for nearly a century. We now know that the diversity is achieved through a 2‐stage process…”
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DNA deamination in immunity: AID in the context of its APOBEC relatives by Conticello, Silvestro G, Langlois, Marc-Andre, Yang, Zizhen, Neuberger, Michael S

“…The activation-induced cytidine deaminase (AID)/apolipoprotein B RNA-editing catalytic component (APOBEC) family is a vertebrate-restricted subgrouping of a…”
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Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1 by LANGLOIS, Marc-André, NEUBERGER, Michael S

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