Search Results - "Neuberg, Donna"

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome by Roemer, Margaretha G M, Advani, Ranjana H, Ligon, Azra H, Natkunam, Yasodha, Redd, Robert A, Homer, Heather, Connelly, Courtney F, Sun, Heather H, Daadi, Sarah E, Freeman, Gordon J, Armand, Philippe, Chapuy, Bjoern, de Jong, Daphne, Hoppe, Richard T, Neuberg, Donna S, Rodig, Scott J, Shipp, Margaret A

“…Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-Sternberg cells within an extensive but ineffective inflammatory/immune cell…”
Get full text

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices by Bird, Gregory H, Mazzola, Emanuele, Opoku-Nsiah, Kwadwo, Lammert, Margaret A, Godes, Marina, Neuberg, Donna S, Walensky, Loren D

“…Detailed biophysical, microscopy, and statistical analyses of hydrocarbon-stapled peptide variants revealed how a combination of critical parameters such as…”
Get full text

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma by Roemer, Margaretha G M, Redd, Robert A, Cader, Fathima Zumla, Pak, Christine J, Abdelrahman, Sara, Ouyang, Jing, Sasse, Stephanie, Younes, Anas, Fanale, Michelle, Santoro, Armando, Zinzani, Pier Luigi, Timmerman, John, Collins, Graham P, Ramchandren, Radhakrishnan, Cohen, Jonathon B, De Boer, Jan Paul, Kuruvilla, John, Savage, Kerry J, Trneny, Marek, Ansell, Stephen, Kato, Kazunobu, Farsaci, Benedetto, Sumbul, Anne, Armand, Philippe, Neuberg, Donna S, Pinkus, Geraldine S, Ligon, Azra H, Rodig, Scott J, Shipp, Margaret A

“…Purpose Hodgkin Reed-Sternberg (HRS) cells evade antitumor immunity by multiple means, including gains of 9p24.1/ CD274(PD-L1)/ PDCD1LG2(PD-L2) and perturbed…”
Get full text

Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas by Kluk, Michael J, Chapuy, Bjoern, Sinha, Papiya, Roy, Alyssa, Dal Cin, Paola, Neuberg, Donna S, Monti, Stefano, Pinkus, Geraldine S, Shipp, Margaret A, Rodig, Scott J

“…Diffuse large B cell lymphoma (DLBCL) is a clinically and genetically heterogeneous disease. A small subset of DLBCLs has translocations involving the MYC…”
Get full text

Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer by Parsons, Heather A, Rhoades, Justin, Reed, Sarah C, Gydush, Gregory, Ram, Priyanka, Exman, Pedro, Xiong, Kan, Lo, Christopher C, Li, Tianyu, Fleharty, Mark, Kirkner, Gregory J, Rotem, Denisse, Cohen, Ofir, Yu, Fangyan, Fitarelli-Kiehl, Mariana, Leong, Ka Wai, Hughes, Melissa E, Rosenberg, Shoshana M, Collins, Laura C, Miller, Kathy D, Blumenstiel, Brendan, Trippa, Lorenzo, Cibulskis, Carrie, Neuberg, Donna S, DeFelice, Matthew, Freeman, Samuel S, Lennon, Niall J, Wagle, Nikhil, Ha, Gavin, Stover, Daniel G, Choudhury, Atish D, Getz, Gad, Winer, Eric P, Meyerson, Matthew, Lin, Nancy U, Krop, Ian, Love, J Christopher, Makrigiorgos, G Mike, Partridge, Ann H, Mayer, Erica L, Golub, Todd R, Adalsteinsson, Viktor A

“…Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for…”
Get full text

A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation by Lazarian, Gregory, Yin, Shanye, ten Hacken, Elisa, Sewastianik, Tomasz, Uduman, Mohamed, Font-Tello, Alba, Gohil, Satyen H., Li, Shuqiang, Kim, Ekaterina, Joyal, Heather, Billington, Leah, Witten, Elizabeth, Zheng, Mei, Huang, Teddy, Severgnini, Mariano, Lefebvre, Valerie, Rassenti, Laura Z., Gutierrez, Catherine, Georgopoulos, Katia, Ott, Christopher J., Wang, Lili, Kipps, Thomas J., Burger, Jan A., Livak, Kenneth J., Neuberg, Donna S., Baran-Marszak, Fanny, Cymbalista, Florence, Carrasco, Ruben D., Wu, Catherine J.

“…Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic lymphocytic leukemia (CLL), but its function remains unknown. Here,…”
Get full text

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage by Hill, Sarah J., Mordes, Daniel A., Cameron, Lisa A., Neuberg, Donna S., Landini, Serena, Eggan, Kevin, Livingston, David M.

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron dysfunction disease that leads to paralysis and death. There is currently no established…”
Get full text

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes by Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Kim, Jaegil, Kamburov, Atanas, Redd, Robert A., Lawrence, Mike S., Roemer, Margaretha G. M., Li, Amy J., Ziepert, Marita, Staiger, Annette M., Wala, Jeremiah A., Ducar, Matthew D., Leshchiner, Ignaty, Rheinbay, Ester, Taylor-Weiner, Amaro, Coughlin, Caroline A., Hess, Julian M., Pedamallu, Chandra S., Livitz, Dimitri, Rosebrock, Daniel, Rosenberg, Mara, Tracy, Adam A., Horn, Heike, van Hummelen, Paul, Feldman, Andrew L., Link, Brian K., Novak, Anne J., Cerhan, James R., Habermann, Thomas M., Siebert, Reiner, Rosenwald, Andreas, Thorner, Aaron R., Meyerson, Matthew L., Golub, Todd R., Beroukhim, Rameen, Wulf, Gerald G., Ott, German, Rodig, Scott J., Monti, Stefano, Neuberg, Donna S., Loeffler, Markus, Pfreundschuh, Michael, Trümper, Lorenz, Getz, Gad, Shipp, Margaret A.

“…Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further…”
Get full text

Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis by Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas

“…Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting…”
Get full text

JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism by Zon, Rebecca L., Sekar, Aswin, Clapham, Katharine, Oren, Ohad, Niroula, Abhishek, Bick, Alexander G., Gibson, Christopher J., Griffin, Gabriel, Uddin, Md Mesbah, Neuberg, Donna, Natarajan, Pradeep, Ebert, Benjamin L.

“…•JAK2-mutant clonal hematopoiesis is associated with a strong risk of VTE.•JAK2-mutant CHIP confers a greater risk of VTE than heterozygous thrombophilia but…”
Get full text

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma by Carey, Christopher D., Gusenleitner, Daniel, Lipschitz, Mikel, Roemer, Margaretha G.M., Stack, Edward C., Gjini, Evisa, Hu, Xihao, Redd, Robert, Freeman, Gordon J., Neuberg, Donna, Hodi, F. Stephen, Liu, Xiaole Shirley, Shipp, Margaret A., Rodig, Scott J.

“…Signaling between programmed cell death protein 1 (PD-1) and the PD-1 ligands (PD-L1, PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS) cells to…”
Get full text

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy by Landau, Dan A., Sun, Clare, Rosebrock, Daniel, Herman, Sarah E. M., Fein, Joshua, Sivina, Mariela, Underbayev, Chingiz, Liu, Delong, Hoellenriegel, Julia, Ravichandran, Sarangan, Farooqui, Mohammed Z. H., Zhang, Wandi, Cibulskis, Carrie, Zviran, Asaf, Neuberg, Donna S., Livitz, Dimitri, Bozic, Ivana, Leshchiner, Ignaty, Getz, Gad, Burger, Jan A., Wiestner, Adrian, Wu, Catherine J.

“…Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by…”
Get full text

Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l -asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial by Place, Andrew E, MD, Stevenson, Kristen E, MS, Vrooman, Lynda M, MD, Harris, Marian H, MD, Hunt, Sarah K, MPH, O'Brien, Jane E, BA, Supko, Jeffrey G, PhD, Asselin, Barbara L, MD, Athale, Uma H, MD, Clavell, Luis A, Prof, Cole, Peter D, MD, Kelly, Kara M, Prof, Laverdiere, Caroline, MD, Leclerc, Jean-Marie, MD, Michon, Bruno, MD, Schorin, Marshall A, Prof, Welch, Jennifer J G, MD, Lipshultz, Steven E, Prof, Kutok, Jeffery L, MD, Blonquist, Traci M, MS, Neuberg, Donna S, ScD, Sallan, Stephen E, Prof, Silverman, Lewis B, Dr

“…Summary Background l -asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered…”
Get full text

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy by GREEN, Michael R, RODIG, Scott, JUSZCZYNSKI, Przemyslaw, JING OUYANG, SINHA, Papiya, O'DONNELL, Evan, NEUBERG, Donna, SHIPP, Margaret A

“…Programmed cell death ligand 1 (PD-L1) is a molecule expressed on antigen-presenting cells that engages the PD-1 receptor on T cells and inhibits T-cell…”
Get full text

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias by Hinze, Laura, Pfirrmann, Maren, Karim, Salmaan, Degar, James, McGuckin, Connor, Vinjamur, Divya, Sacher, Joshua, Stevenson, Kristen E., Neuberg, Donna S., Orellana, Esteban, Stanulla, Martin, Gregory, Richard I., Bauer, Daniel E., Wagner, Florence F., Stegmaier, Kimberly, Gutierrez, Alejandro

“…Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a…”
Get full text

Clinical Effect of Point Mutations in Myelodysplastic Syndromes by Bejar, Rafael, Stevenson, Kristen, Abdel-Wahab, Omar, Galili, Naomi, Nilsson, Björn, Garcia-Manero, Guillermo, Kantarjian, Hagop, Raza, Azra, Levine, Ross L, Neuberg, Donna, Ebert, Benjamin L

“…About half the patients with a myelodysplastic syndrome have one of several genetic mutations. The authors describe some new genetic lesions and show that the…”
Get full text

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients by Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L.

“…Only a minority of myelodysplastic syndrome (MDS) patients respond to hypomethylating agents (HMAs), but strong predictors of response are unknown. We…”
Get full text

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations by Lindsley, R. Coleman, Mar, Brenton G., Mazzola, Emanuele, Grauman, Peter V., Shareef, Sarah, Allen, Steven L., Pigneux, Arnaud, Wetzler, Meir, Stuart, Robert K., Erba, Harry P., Damon, Lloyd E., Powell, Bayard L., Lindeman, Neal, Steensma, David P., Wadleigh, Martha, DeAngelo, Daniel J., Neuberg, Donna, Stone, Richard M., Ebert, Benjamin L.

“…Acute myeloid leukemia (AML) can develop after an antecedent myeloid malignancy (secondary AML [s-AML]), after leukemogenic therapy (therapy-related AML…”
Get full text

Intermediate‐dose anticoagulation, aspirin, and in‐hospital mortality in COVID‐19: A propensity score‐matched analysis by Meizlish, Matthew L., Goshua, George, Liu, Yiwen, Fine, Rebecca, Amin, Kejal, Chang, Eric, DeFilippo, Nicholas, Keating, Craig, Liu, Yuxin, Mankbadi, Michael, McManus, Dayna, Wang, Stephen Y., Price, Christina, Bona, Robert D., Ochoa Chaar, Cassius Iyad, Chun, Hyung J., Pine, Alexander B., Rinder, Henry M., Siner, Jonathan M., Neuberg, Donna S., Owusu, Kent A., Lee, Alfred Ian

“…Thrombotic complications occur at high rates in hospitalized patients with COVID‐19, yet the impact of intensive antithrombotic therapy on mortality is…”
Get full text

Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin by Mantia, Charlene, Uhlmann, Erik J., Puligandla, Maneka, Weber, Griffin M., Neuberg, Donna, Zwicker, Jeffrey I.

“…Venous thromboembolism occurs in up to one-third of patients with primary brain tumors. Spontaneous intracranial hemorrhage (ICH) is also a frequent occurrence…”
Get full text