Search Results - "Neubauer, B L"

Growth Regulation of Prostatic Stromal Cells by Prostate-Specific Antigen by Sutkowski, Debra M., Goode, Robin L., Baniel, Jack, Teater, Carroll, Cohen, Pinchas, McNulty, Ann M., Hsiung, Hansen M., Becker, Gerald W., Neubauer, Blake Lee

“…BACKGROUND: Prostate-specific antigen (PSA) is a serine protease that can cleave insulin-like growth factor-binding protein-3 (IGFBP3), thereby decreasing its…”
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Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen by Adlington, Robert M, Baldwin, Jack E, Becker, Gerald W, Chen, Beining, Cheng, Leifeng, Cooper, Stephen L, Hermann, Robert B, Howe, Trevor J, McCoull, William, McNulty, Ann M, Neubauer, Blake L, Pritchard, Gareth J

“…A homology derived molecular model of prostate specific antigen (PSA) was created and refined. The active site region was investigated for specific interacting…”
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LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5α- Reductase Type 1 by Hirsch, Kenneth S., Jones, Charles D., Audia, James E., Andersson, Stefan, McQuaid, Loretta, Stamm, Nancy B., Neubauer, Blake L., Pennington, Pam, Toomey, Richard E., Russell, David W.

“…Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT…”
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Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase by Jones, Charles D, Audia, James E, Lawhorn, David E, McQuaid, Loretta A, Neubauer, Blake L, Pike, Andrew J, Pennington, Pamela A, Stamm, Nancy B, Toomey, Richard E, Hirsch, Kenneth S

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Epithelial-Mesenchymal Interactions in Prostatic Development. I. Morphological Observations of Prostatic Induction by Urogenital Sinus Mesenchyme in Epithelium of the Adult Rodent Urinary Bladder by Cunha, Gerald R., Fujii, Hirohiko, Neubauer, Blake L., Shannon, John M., Sawyer, Linwood, Reese, Beth A.

“…Tissue recombinants of embryonic urogenital sinus mesenchyme (UGM) and epithelium of the urinary bladder (urothelium, BLE) of adult rats and mice were grown…”
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LY191704 inhibits type I steroid 5α-reductase in human scalp by NEUBAUER, B. L, GRAY, H. M, TINDALL, D. J, TOOMEY, R. E, YAO, R. C, AUDIA, J. E, HANKE, C. W, HIRSCH, K. S, HSIAO, K. C, JONES, C. D, KUMAR, M. V, LAWHORN, D. E, LINDZEY, J, MCQUAID, L

“…Conversion of testosterone to dihydrotestosterone (DHT) has been demonstrated to be catalyzed by two isoforms of steroid 5 alpha-reductase, designated types I…”
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AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon by ZINDA, Michael J, JOHNSON, Mac A, GRAFF, Jeremy R, PAUL, Jonathan D, HORN, Candice, KONICEK, Bruce W, LU, Zhao Hai, SANDUSKY, George, THOMAS, James E, NEUBAUER, Blake Lee, LAI, Mei T

“…Purpose: The AKT/PKB kinase controls many of the intracellular processes that are dysregulated in human cancer, including the suppression of apoptosis and…”
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Expression of Group IIa Secretory Phospholipase A2 Increases with Prostate Tumor Grade by GRAFF, Jeremy R, KONICEK, Bruce W, DEDDENS, James A, CHEDID, Marcio, HURST, Bernadette M, COLLIGAN, Bruce, NEUBAUER, Blake Lee, CARTER, Harry W, CARTER, Julia H

“…Purpose: Arachidonate release contributes to prostate tumor progression as arachidonate is metabolized into prostaglandins and leukotrienes, potent mediators…”
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Ambulatory blood pressure monitoring during pregnancy. Establishment of standards of normalcy by Ferguson, J H, Neubauer, B L, Shaar, C J

“…Ambulatory blood pressure monitoring (ABPM) was used as an effective methodology by a primary care physician to assess normalcy of blood pressure (BP) and…”
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Characterization of type I 5α-reductase activity in DU145 human prostatic adenocarcinoma cells by Kaefer, Martin, Audia, James E., Bruchovsky, Nicholas, Goode, Robin L., Hsiao, Kenneth C., Leibovitch, Ilan Y., Krushinski, Joseph H., Lee, Chung, Steidle, Christopher P., Sutkowski, Debra M., Neubauer, Blake Lee

“…The conversion of testosterone (T) to dihydrotestosterone (DHT) has been demonstrated to be catalysed by at least two isoforms of human steroid 5α-reductase,…”
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Raloxifene (LY156758) produces antimetastatic responses and extends survival in the PAIII rat prostatic adenocarcinoma model by Neubauer, B L, Best, K L, Counts, D F, Goode, R L, Hoover, D M, Jones, C D, Sarosdy, M F, Shaar, C J, Tanzer, L R, Merriman, R L

“…The benzothiophene antiestrogen, raloxifene (LY156758), has selective estrogen pharmacological antagonist activity in rats. The PAIII rat prostatic…”
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Experimental induction of neoplasia in the accessory sex organs of male lobund-wistar rats by HOOVER, D. M, BEST, K. L, MCKENNEY, B. K, TAMURA, R. N, NEUBAUER, B. L

“…Experimental induction of neoplasia in the urogenital tract was studied in male Lobund-Wistar rats. Animals were given single 30.0-mg/kg i.v. injections of…”
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Epithelial-Mesenchymal Interactions in Prostatic Development. II. Biochemical Observations of Prostatic Induction by Urogenital Sinus Mesenchyme in Epithelium of the Adult Rodent Urinary Bladder by Neubauer, Blake Lee, Leland W. K. Chung, McCormick, Kathy A., Taguchi, Osamu, Thompson, Timothy C., Cunha, Gerald R.

“…Adult bladder epithelium (BLE) is induced to differentiate into glandular epithelium after association with urogenital sinus mesenchyme (UGM) and subsequent in…”
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Inhibition of PAIII rat prostatic adenocarcinoma growth and metastasis by a new diarylsulfonylurea antitumor agent, LY181984 by Neubauer, B L, Merriman, R L, Best, K L, Goode, R L, Sarosdy, M F, Tanzer, L R, Howbert, J J

“…LY181984 is a compound in a series of orally active diarylsulfonylureas with broad spectrum in vivo activity against syngeneic rodent and human xenograft tumor…”
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Inhibition of experimentally induced mouse prostatic hyperplasia by castration or steroid antagonist administration by Sikes, R A, Thomsen, S, Petrow, V, Neubauer, B L, Chung, L W

“…Mouse prostatic hyperplasia has been induced experimentally by implanting fetal urogenital sinus tissue into the prostate gland of syngeneic mice. We compared…”
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Bradykinin-induced contractions of canine prostate and bladder: effect of angiotensin-converting enzyme inhibition by Steidle, C P, Cohen, M L, Neubauer, B L

“…Alpha-adrenergic, cholinergic, and serotonergic receptor-mediated contractile responses have been well characterized in the genitourinary tissues of several…”
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Selective estrogen receptor modulators for the chemoprevention of prostate cancer by Steiner, Mitchell S, Raghow, Sharan, Neubauer, Blake L

“…The ability to interfere with prostate carcinogenesis, and as a consequence, prevent prostate cancer with drugs is the basis for chemoprevention. The prostate…”
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Endocrine and antiprostatic effects of raloxifene (LY156758) in the male rat by Neubauer, B L, Best, K L, Clemens, J A, Gates, C A, Goode, R L, Jones, C D, Laughlin, M E, Shaar, C J, Toomey, R E, Hoover, D M

“…The benzothiophene anti-estrogen, raloxifene [LY156758; (6-hydroxy-2-(4-hydroxyphenyl) benzo(b)thien-3-yl)(4-(2-1-piperidinyl)ethoxy)phenyl methanone…”
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Recombinant DNA-derived human insulin-like growth factor II (hIGF-II) stimulates growth in hypophysectomized rats by Shaar, C J, Tinsley, F C, Smith, M C, Clemens, J A, Neubauer, B L

“…Sustained subcutaneous administration of recombinant DNA-derived insulin-like growth factor II to immature female hypophysectomized rats stimulated significant…”
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LY207320 (6-methylene-4-pregnene-3,20-dione) inhibits testosterone biosynthesis, androgen uptake, 5 alpha-reductase, and produces prostatic regression in male rats by Neubauer, B L, Best, K L, Blohm, T R, Gates, C, Goode, R L, Hirsch, K S, Laughlin, M E, Petrow, V, Smalstig, E B, Stamm, N B

“…LY207320 is an in vitro inhibitor (estimated IC50 = 0.06 microM) of steroid 5 alpha-reductase that catalyzes the conversion of testosterone (T) to…”
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