Search Results - "Netto, Luis Eduardo S."
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Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions
Published in Free radical research (01-02-2016)“…Thiol-disulfide exchange reactions are highly reversible, displaying nucleophilic substitutions mechanism (S(N)2 type). For aliphatic, low molecular thiols,…”
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Amperometric microsensor based on nanoporous gold for ascorbic acid detection in highly acidic biological extracts
Published in Analytica chimica acta (25-01-2020)“…Tuning the electrocatalytic properties of high surface area porous metallic frameworks like Nanoporous Gold (NPG) by tailoring the structure is a convenient…”
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3
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity
Published in The FEBS journal (01-09-2022)“…Protein phosphorylation is a major post‐translational modification involved in cell signalling that regulates many physiological and pathological processes…”
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Ohr – OhrR, a neglected and highly efficient antioxidant system: Structure, catalysis, phylogeny, regulation, and physiological roles
Published in Free radical biology & medicine (20-05-2022)“…Ohrs (organic hydroperoxide resistance proteins) are antioxidant enzymes that play central roles in the response of microorganisms to organic peroxides. Here,…”
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On the binding of auranofin to Prdx6 and its potential role in cancer cell sensitivity to treatment
Published in Free radical biology & medicine (01-11-2024)“…In this study, we demonstrate that ferroptosis is a component of the cell death mechanism induced by auranofin in HT-1080 cells, in contrast to the gold(III)…”
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The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence
Published in PLoS pathogens (01-07-2020)“…Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which…”
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Breastmilk-Saliva Interactions Boost Innate Immunity by Regulating the Oral Microbiome in Early Infancy
Published in PloS one (01-09-2015)“…Xanthine oxidase (XO) is distributed in mammals largely in the liver and small intestine, but also is highly active in milk where it generates hydrogen…”
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Additive contributions of two manganese-cored superoxide dismutases (MnSODs) to antioxidation, UV tolerance and virulence of Beauveria bassiana
Published in PloS one (18-01-2012)“…The biocontrol potential of entomopathogenic fungi against arthropod pests depends on not only their virulence to target pests but tolerance to outdoor high…”
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Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity
Published in PloS one (12-01-2015)“…The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing…”
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The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1
Published in PloS one (14-09-2015)“…Starch biosynthesis in Arabidopsis thaliana is strictly regulated. In leaf extracts, starch synthase 1 (AtSS1) responds to the redox potential within a…”
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GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR
Published in PloS one (07-07-2017)“…Glutathione reductase (GSR), a key member of the glutathione antioxidant defense system, converts oxidized glutathione (GSSG) to reduced glutathione (GSH) and…”
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Characterization and mutational analysis of omega-class GST (GSTO1) from Apis cerana cerana, a gene involved in response to oxidative stress
Published in PloS one (25-03-2014)“…The Omega-class of GSTs (GSTOs) is a class of cytosolic GSTs that have specific structural and functional characteristics that differ from those of other GST…”
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Gene expression changes for antioxidants pathways in the mouse cochlea: relations to age-related hearing deficits
Published in PloS one (28-02-2014)“…Age-related hearing loss - presbycusis - is the number one neurodegenerative disorder and top communication deficit of our aged population. Like many aging…”
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Ohr Protects Corynebacterium glutamicum against Organic Hydroperoxide Induced Oxidative Stress
Published in PloS one (29-06-2015)“…Ohr, a bacterial protein encoded by the Organic Hydroperoxide Resistance (ohr) gene, plays a critical role in resistance to organic hydroperoxides. In the…”
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Atypical protein disulfide isomerases (PDI): Comparison of the molecular and catalytic properties of poplar PDI-A and PDI-M with PDI-L1A
Published in PloS one (31-03-2017)“…Protein disulfide isomerases are overwhelmingly multi-modular redox catalysts able to perform the formation, reduction or isomerisation of disulfide bonds. We…”
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The 1.6 Å crystal structure of pyranose dehydrogenase from Agaricus meleagris rationalizes substrate specificity and reveals a flavin intermediate
Published in PloS one (2013)“…Pyranose dehydrogenases (PDHs) are extracellular flavin-dependent oxidoreductases secreted by litter-decomposing fungi with a role in natural recycling of…”
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Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action
Published in PloS one (11-09-2013)“…A chance discovery of the tumoricidal action of a human milk fraction led to the characterization of the active component as oleic acid complex of the…”
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YjcC, a c-di-GMP phosphodiesterase protein, regulates the oxidative stress response and virulence of Klebsiella pneumoniae CG43
Published in PloS one (23-07-2013)“…This study shows that the expression of yjcC, an in vivo expression (IVE) gene, and the stress response regulatory genes soxR, soxS, and rpoS are paraquat…”
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Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma
Published in PloS one (26-05-2015)“…Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis…”
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A 1-Cys Peroxiredoxin from a Thermophilic Archaeon Moonlights as a Molecular Chaperone to Protect Protein and DNA against Stress-Induced Damage
Published in PloS one (01-05-2015)“…Peroxiredoxins (Prxs) act against hydrogen peroxide (H2O2), organic peroxides, and peroxynitrite. Thermococcus kodakaraensis KOD1, an anaerobic archaeon,…”
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