Search Results - "Netto, Jair Machado Espindola"

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging by Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim

“…Recent reports indicate that intracellular NAD levels decline in tissues during chronological aging, and that therapies aimed at increasing cellular NAD levels…”
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Apoptotic stress causes mtDNA release during senescence and drives the SASP by Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

“…Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP) 1 …”
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Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer by Espindola-Netto, Jair Machado, Chini, Claudia C S, Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N

“…NAD salvage is one of the pathways used to generate NAD in mammals. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway,…”
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Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis by Shi, Bo, Wang, Wenxia, Korman, Benjamin, Kai, Li, Wang, Qianqian, Wei, Jun, Bale, Swarna, Marangoni, Roberta Goncalves, Bhattacharyya, Swati, Miller, Stephen, Xu, Dan, Akbarpour, Mahzad, Cheresh, Paul, Proccissi, Daniele, Gursel, Demirkan, Espindola-Netto, Jair Machado, Chini, Claudia C.S., de Oliveira, Guilherme C., Gudjonsson, Johann E., Chini, Eduardo N., Varga, John

“…The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with…”
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Antidiabetic activity of Sedum dendroideum: Metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin by Silva, Daniel, Casanova, Livia Marques, Marcondes, Mariah Celestino, Espindola‐Netto, Jair Machado, Paixão, Larissa Pereira, Melo, Giany Oliveira, Zancan, Patricia, Sola‐Penna, Mauro, Costa, Sônia Soares

“…The aim of this study was to evaluate the antidiabetic potential of a leaf extract and flavonoids from Sedum dendroideum (SD). Additionally, our goals were to…”
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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging by Hayashi, Yujiro, Asuzu, David T., Bardsley, Michael R., Gajdos, Gabriella B., Kvasha, Sergiy M., Linden, David R., Nagy, Rea A., Saravanaperumal, Siva Arumugam, Syed, Sabriya A., Toyomasu, Yoshitaka, Yan, Huihuang, Chini, Eduardo N., Gibbons, Simon J., Kellogg, Todd A., Khazaie, Khashayarsha, Kuro-o, Makoto, Machado Espindola Netto, Jair, Singh, Mahendra Pal, Tidball, James G., Wehling-Henricks, Michelle, Farrugia, Gianrico, Ordog, Tamas

“…Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells…”
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The Use of NMR Metabolite Profiling and in vivo Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Ocimum Species by Casanova, Livia Marques, Espíndola-Netto, Jair Machado, Tinoco, Luzineide Wanderley, Sola-Penna, Mauro, Costa, Sônia Soares

“…Ocimum basilicum and Ocimum gratissimum (Lamiaceae) are used to treat diabetes mellitus in Africa. In a previous work, we identified chicoric acid as a…”
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Strategies for late phase preclinical and early clinical trials of senolytics by Wissler Gerdes, Erin O., Misra, Avanish, Netto, Jair Machado Espindola, Tchkonia, Tamar, Kirkland, James L.

“…•Accumulation of senescent cells is associated with age-related diseases and disorders.•Senolytics and senomorphics are potential interventions for delaying,…”
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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis by Machado, Daniel Escorsim, Perini, Jamila Alessandra, de Mendonça, Erika Menezes, Branco, Jessica Ristow, Rodrigues-Baptista, Karina Cristina, Alessandra-Perini, Jessica, Espíndola-Netto, Jair Machado, dos Santos, Thiago Alves, Coelho, Wagner Santos, Nasciutti, Luiz Eurico, Sola-Penna, Mauro, Zancan, Patricia

“…The present work aimed to evaluate molecular, angiogenic and inflammatory changes induced by clotrimazole (CTZ) on endometriosis lesions. For this, thirty…”
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Senolytics reduce coronavirus-related mortality in old mice by Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D

“…The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically ill to severe acute respiratory syndrome coronavirus 2…”
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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 by Tripathi, Utkarsh, Nchioua, Rayhane, Prata, Larissa G P Langhi, Zhu, Yi, Gerdes, Erin O Wissler, Giorgadze, Nino, Pirtskhalava, Tamar, Parker, Erik, Xue, Ailing, Espindola-Netto, Jair Machado, Stenger, Steffen, Robbins, Paul D, Niedernhofer, Laura J, Dickinson, Stephanie L, Allison, David B, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and can express a pro-inflammatory, tissue-destructive…”
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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels by Chini, Claudia C. S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.

“…Decreased NAD + levels have been shown to contribute to metabolic dysfunction during aging. NAD + decline can be partially prevented by knockout of the enzyme…”
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The Pharmacology of CD38/NADase: An emerging target for cancer and aging diseases by Chini, Eduardo N., Chini, Claudia C.S., Netto, Jair Machado Espindola, de Oliveira, Guilherme C., van Schooten, Wim

“…Recent reports indicate that intracellular levels of NAD decline in tissues during chronological aging, and that therapies aim at increasing cellular NAD…”
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Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP by Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.

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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans by Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.

“…α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the…”
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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During AgingSummary by Yujiro Hayashi, David T. Asuzu, Michael R. Bardsley, Gabriella B. Gajdos, Sergiy M. Kvasha, David R. Linden, Rea A. Nagy, Siva Arumugam Saravanaperumal, Sabriya A. Syed, Yoshitaka Toyomasu, Huihuang Yan, Eduardo N. Chini, Simon J. Gibbons, Todd A. Kellogg, Khashayarsha Khazaie, Makoto Kuro-o, Jair Machado Espindola Netto, Mahendra Pal Singh, James G. Tidball, Michelle Wehling-Henricks, Gianrico Farrugia, Tamas Ordog

“…Background & Aims: Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells…”
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CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+ and NMN levels by Chini, Claudia C.S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.

“…Decreased nicotinamide adenine dinucleotide (NAD + ) levels have been shown to contribute to metabolic dysfunction during aging. NAD + decline can be partially…”
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