Search Results - "Nettles, James H"

Substrates and Inhibitors of SAMHD1 by Hollenbaugh, Joseph A, Shelton, Jadd, Tao, Sijia, Amiralaei, Sheida, Liu, Peng, Lu, Xiao, Goetze, Russell W, Zhou, Longhu, Nettles, James H, Schinazi, Raymond F, Kim, Baek

“…SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the…”
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The Binding Conformation of Taxol in β-Tubulin: A Model Based on Electron Crystallographic Density by Snyder, James P., Nettles, James H., Cornett, Ben, Downing, Kenneth H., Nogales, Eva

“…The chemotherapeutic drug Taxol is known to interact within a specific site on β-tubulin. Although the general location of the site has been defined by…”
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Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules by Hari, Malathi, Loganzo, Frank, Annable, Tami, Tan, Xingzhi, Musto, Sylvia, Morilla, Daniel B, Nettles, James H, Snyder, James P, Greenberger, Lee M

“…Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well…”
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Drugs that target dynamic microtubules: A new molecular perspective by Stanton, Richard A., Gernert, Kim M., Nettles, James H., Aneja, Ritu

“…Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle…”
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Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition by Judd, Deborah A, Nettles, James H, Nevins, Neysa, Snyder, James P, Liotta, Dennis C, Tang, Jordan, Ermolieff, Jacques, Schinazi, Raymond F, Hill, Craig L

“…Nb-containing polyoxometalates (POMs) of the Wells−Dawson class inhibit HIV-1 protease (HIV-1P) by a new mode based on kinetics, binding, and molecular…”
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Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function by Schafer-Hales, Katherine, Iaconelli, Jon, Snyder, James P, Prussia, Andrew, Nettles, James H, El-Naggar, Adel, Khuri, Fadlo R, Giannakakou, Paraskevi, Marcus, Adam I

“…Farnesyl transferase inhibitors (FTI) exhibit anticancer activity as a single agent in preclinical studies and show promise in combination with other…”
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Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV by Wadford, Debra A, Kauffman, Robert C, Deere, Jesse D, Aoki, Scott T, Stanton, Richard A, Higgins, Joanne, Van Rompay, Koen K A, Villalobos, Andradi, Nettles, James H, Schinazi, Raymond F, Pedersen, Niels C, North, Thomas W

“…RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1…”
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Rational design of the microtubule-targeting anti-breast cancer drug EM015 by ANEJA, Ritu, LOPUS, Manu, CHANDRA, Ramesh, JOSHI, Harish C, JUN ZHOU, VANGAPANDU, Surya N, GHALEB, Amr, YAO, Joyce, NETTLES, James H, BINFEI ZHOU, GUPTA, Meenakshi, PANDA, Dulal

“…We studied in silico docking of noscapine onto tubulin, combined with calculations of surface charge, pi-pi, van der Waals, and hydrogen bonding interactions,…”
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Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase by SCHINAZI, Raymond F, MASSUD, Ivana, RAPP, Kimberly L, CRISTIANO, Meta, DETORIO, Mervi A, STANTON, Richard A, BENNETT, Matthew A, KIERLIN-DUNCAN, Monique, LENNERSTRAND, Johan, NETTLES, James H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition by Nettles, James H, Stanton, Richard A, Broyde, Joshua, Amblard, Franck, Zhang, Hongwang, Zhou, Longhu, Shi, Junxing, McBrayer, Tamara R, Whitaker, Tony, Coats, Steven J, Kohler, James J, Schinazi, Raymond F

“…Symmetric, dimeric daclatasvir (BMS-790052) is the clinical lead for a class of picomolar inhibitors of HCV replication. While specific, resistance-bearing…”
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The Binding Mode of Epothilone A on α,β-Tubulin by Electron Crystallography by Nettles, James H., Li, Huilin, Cornett, Ben, Krahn, Joseph M., Snyder, James P., Downing, Kenneth H.

“…The structure of epothilone A, bound to α,β-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom…”
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Bridging Chemical and Biological Space:  “Target Fishing” Using 2D and 3D Molecular Descriptors by Nettles, James H, Jenkins, Jeremy L, Bender, Andreas, Deng, Zhan, Davies, John W, Glick, Meir

“…Bridging chemical and biological space is the key to drug discovery and development. Typically, cheminformatics methods operate under the assumption that…”
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“Bayes Affinity Fingerprints” Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space:  When Are Multitarget Drugs a Feasible Concept? by Bender, Andreas, Jenkins, Jeremy L, Glick, Meir, Deng, Zhan, Nettles, James H, Davies, John W

“…Conventional similarity searching of molecules compares single (or multiple) active query structures to each other in a relative framework, by means of a…”
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Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors by Stanton, Richard A., Lu, Xiao, Detorio, Mervi, Montero, Catherine, Hammond, Emily T., Ehteshami, Maryam, Domaoal, Robert A., Nettles, James H., Feraud, Michel, Schinazi, Raymond F.

“…[Display omitted] A library of 585 compounds built off a 7-azaindole core was evaluated for anti-HIV-1 activity, and ten hits emerged with submicromolar…”
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Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors by Stanton, Richard A., Nettles, James H., Schinazi, Raymond F.

“…Non-nucleoside reverse transcriptase inhibitors (NNRTI) are allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), a…”
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Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers by Glick, Meir, Jenkins, Jeremy L, Nettles, James H, Hitchings, Hamilton, Davies, John W

“…High-throughput screening (HTS) plays a pivotal role in lead discovery for the pharmaceutical industry. In tandem, cheminformatics approaches are employed to…”
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Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors by Boucle, Sebastien, Tao, Sijia, Amblard, Franck, Stanton, Richard A., Nettles, James H., Li, Chengwei, McBrayer, Tamara R., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.

“…[Display omitted] The design and synthesis of new non-symmetrical NS5A inhibitors with sulfur containing amino acids is reported along with their ability to…”
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Synthesis and evaluation of non-dimeric HCV NS5A inhibitors by Amblard, Franck, Zhang, Hongwang, Zhou, Longhu, Shi, Junxing, Bobeck, Drew R., Nettles, James H., Chavre, Satish, McBrayer, Tamara R., Tharnish, Philip, Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.

“…Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new…”
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Microtubule-interacting drugs for cancer treatment by Checchi, Paula M, Nettles, James H, Zhou, Jun, Snyder, James P, Joshi, Harish C

“…Microtubule-interacting drugs are important agents in cancer chemotherapy. Some of these drugs alter microtubule dynamics and engage the cell cycle…”
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Approaches to hepatitis C treatment and cure using NS5A inhibitors by Kohler, James J, Nettles, James H, Amblard, Franck, Hurwitz, Selwyn J, Bassit, Leda, Stanton, Richard A, Ehteshami, Maryam, Schinazi, Raymond F

“…Recent progress in the understanding of hepatitis C virus (HCV) biology and the availability of in vitro models to study its replication have facilitated the…”
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