Search Results - "Nettesheim, David G."

Solution Structure of the Antiapoptotic Protein bcl-2 by Petros, Andrew M., Medek, Ales, Nettesheim, David G., Kim, Daniel H., Yoon, Ho Sup, Swift, Kerry, Matayoshi, Edmund D., Oltersdorf, Tilman, Fesik, Stephen W.

“…The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in…”
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Discovery of a novel small molecule binding site of human survivin by Wendt, Michael D., Sun, Chaohong, Kunzer, Aaron, Sauer, Daryl, Sarris, Kathy, Hoff, Ethan, Yu, Liping, Nettesheim, David G., Chen, Jun, Jin, Sha, Comess, Kenneth M., Fan, Yihong, Anderson, Steven N., Isaac, Binumol, Olejniczak, Edward T., Hajduk, Philip J., Rosenberg, Saul H., Elmore, Steven W.

“…Survivin is one of the most tumor-specific genes in the human genome and is an attractive target for cancer therapy. However, small-molecule ligands for…”
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours by Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

“…Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed…”
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis by Petros, Andrew M, Dinges, Jurgen, Augeri, David J, Baumeister, Steven A, Betebenner, David A, Bures, Mark G, Elmore, Steven W, Hajduk, Philip J, Joseph, Mary K, Landis, Shelley K, Nettesheim, David G, Rosenberg, Saul H, Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W

“…The antiapoptotic proteins Bcl-xL and Bcl-2 play key roles in the maintenance of normal cellular homeostasis. However, their overexpression can lead to…”
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Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator by Hansen, Andrew P, Petros, Andrew M, Meadows, Robert P, Nettesheim, David G, Mazar, Andrew P, Olejniczak, Edward T, Xu, Robert X, Pederson, Terry M, Henkin, Jack, Fesik, Stephen W

“…The amino-terminal fragment (ATF) of urokinase-type plasminogen activator is a two domain protein which consists of a growth factor and a kringle domain. The…”
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The Secondary Structure of the Ets Domain of Human Fli-1 Resembles that of the Helix-Turn-Helix DNA-Binding Motif of the Escherichia coli Catabolite Gene Activator Protein by Liang, H, Olejniczak, E T, Mao, X, Nettesheim, D G, Yu, L, Thompson, C B, Fesik, S W

“…The ets family of eukaryotic transcription factors is characterized by a conserved DNA-binding domain of ≈85 amino acids for which the three-dimensional…”
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NMR-Based Modification of Matrix Metalloproteinase Inhibitors with Improved Bioavailability by Hajduk, Philip J, Shuker, Suzanne B, Nettesheim, David G, Craig, Richard, Augeri, David J, Betebenner, David, Albert, Daniel H, Guo, Yan, Meadows, Robert P, Xu, Lianhong, Michaelides, Michael, Davidsen, Steven K, Fesik, Stephen W

“…The NMR-based discovery of biaryl hydroxamate inhibitors of the matrix metalloproteinase stromelysin (MMP-3) has been previously described (Hajduk et al. J…”
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Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data by Zuiderweg, Erik R. P, Nettesheim, David G, Mollison, Karl W, Carter, George W

“…The tertiary structure for the region 1-63 of the 74 amino acid human complement protein C5a in solution was calculated from a large number of distance…”
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Improved NMR Structures of Protein/Ligand Complexes Using Residual Dipolar Couplings by Olejniczak, Edward T, Meadows, Robert P, Wang, Hong, Cai, Mengli, Nettesheim, David G, Fesik, Stephen W

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Solution structure of the ets domain of Fli-1 when bound to DNA by Liang, Heng, Mao, Xiaohong, Olejniczak, Edward T, Nettesheim, David G, Yu, Liping, Meadows, Robert P, Thompson, Craig B, Fesik, Stephen W

“…Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the…”
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Solution Structure of a Low Molecular Weight Protein Tyrosine Phosphatase by Logan, Timothy M, Zhou, Ming-Ming, Nettesheim, David G, Meadows, Robert P, Van Etten, Robert L, Fesik, Stephen W

“…Protein tyrosine phosphatases (PTPs) are important enzymes involved in signal transduction, cell cycle regulation, and the control of differentiation. Despite…”
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis by Petros, Andrew M., Dinges, Jurgen, Augeri, David J., Baumeister, Steven A., Betebenner, David A., Bures, Mark G., Elmore, Steven W., Hajduk, Philip J., Joseph, Mary K., Landis, Shelley K., Nettesheim, David G., Rosenberg, Saul H., Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W.

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Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR by Meadows, Robert P, Nettesheim, David G, Xu, Robert X, Olejniczak, Edward T, Petros, Andrew M, Holzman, Thomas F, Severin, Jean, Gubbins, Earl, Smith, Harriet, Fesik, Stephen W

“…A high-resolution three-dimensional solution structure of the FKBP/ascomycin complex has been determined using heteronuclear multidimensional nuclear magnetic…”
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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies by PETROS, ANDREW M., NETTESHEIM, DAVID G., WANG, YI, OLEJNICZAK, EDWARD T., MEADOWS, ROBERT P., MACK, JAMEY, SWIFT, KERRY, MATAYOSHI, EDMUND D., ZHANG, HAICHAO, THOMPSON, CRAIG B., FESIK, STEPHEN W.

“…The three-dimensional structure of the anti-apoptotic protein Bcl-xL complexed to a 25-residue peptide from the death promoting region of Bad was determined…”
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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies by PETROS, ANDREW M., NETTESHEIM, DAVID G., WANG, YI, OLEJNICZAK, EDWARD T., MEADOWS, ROBERT P., MACK, JAMEY, SWIFT, KERRY, MATAYOSHI, EDMUND D., ZHANG, HAICHAO, THOMPSON, CRAIG B., FESIK, STEPHEN W.

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Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12 by Wiedeman, Paul E, Fesik, Stephen W, Petros, Andrew M, Nettesheim, David G, Mollison, Karl W, Lane, Benjamin C, Or, Yat Sun, Luly, Jay R

“…C24-Deoxyascomycin was prepared in a two-step process from ascomycin and evaluated for its immunosuppressant activity relative to ascomycin and FK506. An…”
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Sequential resonance assignments of oxidized high-potential iron-sulfur protein from Chromatium vinosum by Nettesheim, David G, Harder, Scott R, Feinberg, Benjamin A, Otvos, James D

“…2D NMR spectra of the high-potential iron-sulfur protein (HiPIP) from Chromatium vinosum have been used to obtain partial resonance assignments for the…”
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Products of metal exchange reactions of metallothionein by Nettesheim, David G, Engeseth, Helen R, Otvos, James D

“…Hepatic metallothionein (MT) isolated from Cd-exposed animals always contains Zn (2-3 mol/mol of protein) in addition to Cd (4-5 mol/mol of protein), and the…”
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Proton nuclear magnetic resonance studies on the variant-3 neurotoxin from Centruroides sculpturatus Ewing: sequential assignment of resonances by Nettesheim, David G, Klevit, Rachel E, Drobny, Gary, Watt, Dean D, Krishna, N. Rama

“…We report the sequential assignment of resonances to specific residues in the proton nuclear magnetic resonance spectrum of the variant-3 neurotoxin from the…”
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Proton nuclear magnetic resonance characterization of the aromatic residues in the variant-3 neurotoxin from Centruroides sculpturatus Ewing by Krishna, N. Rama, Nettesheim, David G, Klevit, Rachel E, Drobny, Gary, Watt, Dean D, Bugg, Charles E

“…The amino acid sequence for the variant-3 (CsE-v3) toxin from the venom of the scorpion Centruroides sculpturatus Ewing contains eight aromatic residues. By…”
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