Search Results - "Neto, Nuno G. B"
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A preclinical model of cutaneous melanoma based on reconstructed human epidermis
Published in Scientific reports (29-09-2022)“…Malignant melanoma is among the tumor entities with the highest increase of incidence worldwide. To elucidate melanoma progression and develop new effective…”
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2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified
Published in Stem cell research & therapy (12-12-2023)“…Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated…”
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Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning
Published in eLife (18-10-2022)“…In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting…”
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Core-Assisted Formation of Porphyrin J-Aggregates in pH-Sensitive Polyelectrolyte Microcapsules Followed by Fluorescence Lifetime Imaging Microscopy
Published in Langmuir (08-08-2017)“…A strategy assisted by an inorganic template was developed to promote the organized self-assembly of meso-(tetrakis)-(p-sulfonatophenyl)porphyrin (TPPS) on…”
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The Trypanosoma brucei -Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells
Published in Antioxidants (15-01-2022)“…The extracellular parasite and causative agent of African sleeping sickness ( ) has evolved a number of strategies to avoid immune detection in the host. One…”
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Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages
Published in Atherosclerosis (01-07-2022)“…Metabolic reprogramming of innate immune cells is emerging as a key player in the progression of a number of chronic diseases, including atherosclerosis, where…”
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Macrophage metabolic profile is altered by hydroxyapatite particle size
Published in Acta biomaterialia (01-04-2023)“…Since the recent observation that immune cells undergo metabolic reprogramming upon activation, there has been immense research in this area to not only…”
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Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
Published in Science advances (27-09-2024)“…This study performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), "individuals at…”
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Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis
Published in Biochemistry and biophysics reports (01-03-2023)“…Thoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the myostatin (MSTN) gene which determines aptitude for certain…”
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SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
Published in Life science alliance (01-05-2020)“…Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the…”
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