Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Tuberculosis and intestinal parasites affect primarily low social and economic level populations, living clustered in precarious habitational settings. One of the interesting aspects of this interaction is the parasitism influence in cellular response to tuberculosis. In the present study, we evalua...

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Published in:The Brazilian journal of infectious diseases Vol. 13; no. 6; pp. 427 - 432
Main Authors: Neto, Luanda M S, Oliveira, Raquel de Vasconcellos Carvalhaes de, Totino, Paulo Renato, Sant'Anna, Flavia Marinho, Coelho, Viviane de Oliveira, Rolla, Valeria Cavalcanti, Zanini, Graziela Maria
Format: Journal Article
Language:English
Published: Brazil Brazilian Society of Infectious Diseases 01-12-2009
Elsevier
Subjects:
Adult
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - mortality
Brazil - epidemiology
Female
Helminthiasis - epidemiology
Helminthiasis - mortality
Humans
INFECTIOUS DISEASES
Intestinal Diseases, Parasitic - epidemiology
Intestinal Diseases, Parasitic - mortality
intestinal parasites
Male
Middle Aged
Parasitemia - epidemiology
Parasitemia - mortality
Prevalence
Protozoan Infections - epidemiology
Protozoan Infections - mortality
survival
tuberculin skin test
Tuberculin Test
Tuberculosis
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - mortality
Brazil
intestinal parasites
Tuberculosis
tuberculin skin test
survival
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Summary:Tuberculosis and intestinal parasites affect primarily low social and economic level populations, living clustered in precarious habitational settings. One of the interesting aspects of this interaction is the parasitism influence in cellular response to tuberculosis. In the present study, we evaluated the prevalence of enteroparasitosis in tuberculosis patients, HIV-infected and non HIV infected, and we observed the influence of helminth presence in the response to tuberculin skin test (TST) and tuberculosis clinical outcomes. From 607 clinical records reviewed, 327 individuals met the study inclusion criteria and did not present any exclusion criteria. The prevalence of enteroparasites observed was 19.6%. There was no significant association among TST result and the variables related to the presence of: helminthes, protozoa, and stool test for parasites result (p>0.5). Considering the survival of this cohort, we may observe that there is no significant difference (p>0.05) between the survival curves of parasited and non parasited individuals. Solely the variable "eosinophils" presents a statistically significant association (p<0.001) with helminthes, all other associations are considered not significant. Our findings neither show an association between helminthic infection and a favorable tuberculosis outcome, nor between parasitism and TST response, unlike other in vitro studies. Apparently, experimental data do not correspond to the clinical findings.
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ISSN:1678-4391
1678-4391
DOI:10.1590/S1413-86702009000600008