Search Results - "Neto, Joao Agostinho"

Territorialization using georreferencing and stratification of the social vulnerability of families in Primary Care by Oliveira Calistro, Monyelle de, Teixeira, Ygor, Silva Lacerda, Izabel Ricaelle Argentino, Mendes de Sousa, Samara, Neto, Joao Agostinho, Pimentel Duavy, Sandra Mara, Brito, Francisco Elizaudo, Jr. de

“…This article describes a process of territorialization undertaken in Family Health Strategy micro-areas by a team of residents from the Interprofessional…”
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Stathmin 1, a Therapeutic Target in Esophageal Carcinoma? by Machado-Neto, Joao Agostinho

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Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes by Bruna Oliveira De Almeida, João Agostinho Machado-neto

“…ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain…”
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Stathmin 1 in normal and malignant hematopoiesis by Machado-Neto, Joao Agostinho, Saad, Sara Teresinha Olalla, Traina, Fabiola

“…Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and…”
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Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms by Takei, Hisashi, Coelho‐Silva, Juan Luiz, Tavares Leal, Cristina, Queiroz Arantes Rocha, Adriana, Mantello Bianco, Thiago, Welner, Robert S., Mishima, Yuta, Kobayashi, Ikei S., Mullally, Ann, Lima, Keli, Machado‐Neto, João Agostinho, Kobayashi, Susumu S., Lobo de Figueiredo‐Pontes, Lorena

“…Several lines of research suggest that Bcl‐xL‐mediated anti‐apoptotic effects may contribute to the pathogenesis of myeloproliferative neoplasms driven by…”
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Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development by Salata, Giovanna Cassone, Malagó, Isabella D, Carvalho Dartora, Vanessa F. M, Marçal Pessoa, Ana Flávia, Fantini, Márcia Carvalho de Abreu, Costa, Soraia K. P, Machado-Neto, João Agostinho, Lopes, Luciana B

“…The need of pharmacological strategies to preclude breast cancer development motivated us to develop a non-aqueous microemulsion (ME) capable of forming a…”
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Data mining in acute myeloid leukemia: identification of disease biomarkers, prognostic factors, novel targets, and potential drugs by Machado-Neto, João Agostinho, do Nascimento, Mariane Cristina, Garnique, Anali Del Milagro Bernabe, Lima, Keli

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Autophagy and inflammasome activation are associated with poor response to FLT3 inhibitors in patients with FLT3-ITD acute myeloid leukemia by Santos de Macedo, Brunno Gilberto, Albuquerque de Melo, Manuela, Pereira-Martins, Diego Antonio, Machado-Neto, João Agostinho, Traina, Fabíola

“…Beyond its clinical diversity and severity, acute myeloid leukemia (AML) is known for its complex molecular background and for rewiring biological processes to…”
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Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression by Roversi, Fernanda Marconi, Olalla Saad, Sara Teresinha, Machado-Neto, João Agostinho

“…Understanding the molecular basis and mechanisms involved in neoplastic transformation and progression is important for the development of novel selective…”
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IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells by Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Fenerich, Bruna Alves, Coelho-Silva, Juan Luiz, Scheucher, Priscila Santos, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Ridley, Anne J., Machado-Neto, João Agostinho, Traina, Fabiola

“…The IGF1R/IRS1 signaling is activated in acute lymphoblastic leukemia (ALL) and can be targeted by the pharmacological inhibitors NT157 (IGF1R-IRS1/2…”
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IRS1/β‐Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells by Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Machado‐Neto, João Agostinho, Scopim‐Ribeiro, Renata, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola

“…ABSTRACT Insulin‐like growth factor 1 (IGF1) and its receptor IGF1R regulate normal cell growth and contribute to cell transformation through activation of…”
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Cellular and Molecular Effects of Eribulin in Preclinical Models of Hematologic Neoplasms by Vicari, Hugo Passos, Lima, Keli, Costa-Lotufo, Leticia Veras, Machado-Neto, João Agostinho

“…Despite the advances in understanding the biology of hematologic neoplasms which has resulted in the approval of new drugs, the therapeutic options are still…”
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NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells by de Miranda, Lívia Bassani Lins, Lima, Keli, Coelho-Silva, Juan Luiz, Traina, Fabiola, Kobayashi, Susumu S., Machado-Neto, João Agostinho

“…Combination therapies or multi-targeted drugs have been pointed out as an option to prevent the emergence of resistant clones, which could make long-term…”
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Up‐regulation of SPINT2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion by Roversi, Fernanda Marconi, Cury, Nathalia Moreno, Lopes, Matheus Rodrigues, Ferro, Karla Priscila, Machado‐Neto, João Agostinho, Alvarez, Marisa Claudia, Santos, Gabriela Pereira, Giardini Rosa, Renata, Longhini, Ana Leda, Duarte, Adriana da Silva Santos, Pericole, Fernando Vieira, Favaro, Patricia, Yunes, José Andres, Saad, Sara Teresinha Olalla

“…The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal…”
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FMNL1 promotes proliferation and migration of leukemia cells by Favaro, Patricia, Traina, Fabiola, Machado‐Neto, João Agostinho, Lazarini, Mariana, Lopes, Matheus Rodrigues, Pereira, João Kleber Novais, Costa, Fernando Ferreira, Infante, Elvira, Ridley, Anne J., Saad, Sara Teresinha Olalla

“…FMNL1 regulates leukemic cell proliferation, clonogenicity, migration, and interaction with endothelial cells, supporting a potential role in leukemogenesis…”
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Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes by Almeida, Bruna Oliveira de, Machado-Neto, João Agostinho

“…ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain…”
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Pharmacological Inhibition of PIP4K2 Potentiates Venetoclax-Induced Apoptosis in Acute Myeloid Leukemia by Lima, Keli, Carvalho, Maria Fernanda Lopes, Pereira-Martins, Diego Antonio, Nogueira, Frederico Lisboa, de Miranda, Lívia Bassani Lins, Nascimento, Mariane Cristina do, Cavaglieri, Rita de Cássia, Schuringa, Jan Jacob, Machado-Neto, João Agostinho, Rego, Eduardo Magalhães

“…Phosphatidylinositol-5-phosphate 4-kinase type 2 (PIP4K2) protein family members (PIP4K2A, PIP4K2B, and PIP4K2C) participate in the generation of PIP , P ,…”
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Chromomycin A5 induces bona fide immunogenic cell death in melanoma by Florêncio, Katharine Gurgel Dias, Edson, Evelline Araújo, Fernandes, Keilla Santana da Silva, Luiz, João Paulo Mesquita, Pinto, Francisco das Chagas Lima, Pessoa, Otília Deusdênia Loiola, Cunha, Fernando de Queiroz, Machado-Neto, João Agostinho, Wilke, Diego Veras

“…PurposeSome first-line cytotoxic chemotherapics, e.g. doxorubicin, paclitaxel and oxaliplatin, induce activation of the immune system through immunogenic cell…”
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Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas by Hirata, Amanda S, Rezende-Teixeira, Paula, Machado-Neto, João Agostinho, Jimenez, Paula C, Clair, James J La, Fenical, William, Costa-Lotufo, Leticia V

“…Isolated from the marine bacteria sp., seriniquinone ( ) has been characterized by its selective activity in melanoma cell lines marked by its modulation of…”
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Stathmin 1 in normal and malignant hematopoiesis by Machado-Neto, João Agostinho, Saad, Sara Teresinha Olalla, Traina, Fabiola

“…Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and…”
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