Search Results - "Nethery, David E"

Neuregulin-1-Human Epidermal Receptor-2 Signaling Is a Central Regulator of Pulmonary Epithelial Permeability and Acute Lung Injury by Finigan, James H., Faress, Jihane A., Wilkinson, Emily, Mishra, Rangnath S., Nethery, David E., Wyler, David, Shatat, Mohammad, Ware, Lorraine B., Matthay, Michael A., Mason, Robert, Silver, Richard F., Kern, Jeffrey A.

“…The mechanisms behind the loss of epithelial barrier function leading to alveolar flooding in acute lung injury (ALI) are incompletely understood. We…”
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Brainstem inflammation modulates the ventilatory pattern and its variability after acute lung injury in rodents by Hsieh, Yee‐Hsee, Litvin, David G, Zaylor, Abigail R, Nethery, David E, Dick, Thomas E, Jacono, Frank J

“…Key points Compared with sham rats, rats a week after acute lung injury (ALI) express more pro‐inflammatory cytokines in their brainstem respiratory control…”
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Inactivation of neuregulin-1 by nitration by Nethery, David E, Ghosh, Sudakshina, Erzurum, Serpil C, Kern, Jeffrey A

“…Nitration is a posttranslational modification that can compromise protein function. We hypothesized that nitration of growth factors secreted in the lung may…”
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Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats by Campanaro, Cara K, Nethery, David E, Guo, Fei, Kaffashi, Farhad, Loparo, Kenneth A, Jacono, Frank J, Dick, Thomas E, Hsieh, Yee-Hsee

“…Biometrics of common physiologic signals can reflect health status. We have developed analytics to measure the predictability of ventilatory pattern…”
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AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations by Darrah, Rebecca J., Jacono, Frank J., Joshi, Neha, Mitchell, Anna L., Sattar, Abdus, Campanaro, Cara K., Litman, Paul, Frey, Jennifer, Nethery, David E., Barbato, Eric S., Hodges, Craig A., Corvol, Harriet, Cutting, Garry R., Knowles, Michael R., Strug, Lisa J., Drumm, Mitchell L.

“…Pulmonary disease remains the primary cause of morbidity and mortality for individuals with cystic fibrosis (CF). Variants at a locus on the X-chromosome…”
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Cannabinoid Receptor mRNA Expression in Central and Peripheral Tissues in a Rodent Model of Peritonitis by Horton, Kofi-Kermit A, Campanaro, Cara K, Clifford, Caitlyn, Nethery, David E, Strohl, Kingman P, Jacono, Frank J, Dick, Thomas E

“…Our laboratory investigates changes in the respiratory pattern during systemic inflammation in various rodent models. The endogenous cannabinoid system (ECS)…”
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Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation by FINIGAN, James H, MISHRA, Rangnath, VASU, Vihas T, SILVEIRA, Lori J, NETHERY, David E, STANDIFORD, Theodore J, BURNHAM, Ellen L, MOSS, Marc, KERN, Jeffrey A

“…Shedding of neuregulin (NRG)-1 from the pulmonary epithelium leads to activation of the epithelial human epidermal growth factor receptor (HER)2 receptor,…”
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Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2 by Faress, Jihane A, Nethery, David E, Kern, Elizabeth F. O, Eisenberg, Rosana, Jacono, Frank J, Allen, Chris L, Kern, Jeffrey A

“…Divisions of 1 Pulmonary, Critical Care and Sleep Medicine, and 2 Clinical and Molecular Endocrinology, and 3 Departments of Internal Medicine and Pathology,…”
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Development of brainstem inflammation correlates with uncoupling of the cardiorespiratory system in an endotoxemic rodent model by Dick, Thomas E, Hsieh, Yee-Hsee, Litvin, David, Nethery, David E, Zhu, Yenan, Galan, Roberto F, Wilson, Christopher G, Loparo, Kenneth A, Jacono, Frank J

“…[...]we addressed the hypothesis that downstream products in the inflammatory cascade reduced synaptic efficacy in the nTS…”
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Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice by Nethery, David E, Moore, Bethany B, Minowada, George, Carroll, James, Faress, Jihane A, Kern, Jeffrey A

“…1 Department of Internal Medicine, Pulmonary and Critical Care Division, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio; 2…”
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Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis by Callahan, Leigh A, Stofan, Daniel A, Szweda, Luke I, Nethery, David E, Supinski, Gerald S

“…Recent studies indicate that sepsis is associated with enhanced generation of several free radical species (nitric oxide, superoxide, hydrogen peroxide) in…”
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Dynamics of Ventilatory Pattern Variability (VPV), Cardio‐Respiratory Coupling (CRC) and Cytokines in an E. coli Sepsis Model by Tackett, Shiloh H, Solanki, Neha, Nethery, David E, Horton, Kofi‐Kermit A, Bonfield, Tracey L, Jacono, Frank J, Dick, Thomas E

“…Cardio‐respiratory control is disrupted in sepsis. We hypothesized that increases in inflammatory cytokines that are expressed in the brainstem in a rat model…”
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Modulation of mRNA Expression in Peripheral Tissue in a Rodent E. coli Sepsis Model by Horton, Kofi‐Kermit A, Clifford, Caitlyn, Tackett, Shiloh H, Nethery, David E, Dick, Thomas E, Jacono, Frank J, Strohl, Kingman P

“…The endogenous cannabinoid system (ECS) regulates cytokine production and mitigates pathophysiology in many pro‐inflammatory conditions, such as irritable…”
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Modulation of release of reactive oxygen species by the contracting diaphragm by STOFAN, D. A, CALLAHAN, L. A, DIMARCO, A. F, NETHERY, D. E, SUPINSKI, G. S

“…Recent reports have demonstrated that superoxide is released by the contracting diaphragm. Moreover, extracellular scavengers of superoxide (i.e., exogenously…”
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