Search Results - "Netea, Mihai G."

Considering BCG vaccination to reduce the impact of COVID-19 by Curtis, Nigel, Sparrow, Annie, Ghebreyesus, Tedros A, Netea, Mihai G

“…In addition to its specific effect against tuberculosis, the BCG vaccine has beneficial nonspecific (off-target) effects on the immune system that protect…”
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The immunopathology of sepsis and potential therapeutic targets by van der Poll, Tom, van de Veerdonk, Frank L., Scicluna, Brendon P., Netea, Mihai G.

“…Key Points Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The sepsis-associated host response is…”
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Trained immunity-related vaccines: innate immune memory and heterologous protection against infections by Ziogas, Athanasios, Netea, Mihai G.

“…The innate immune system is able to build memory-like features in response to certain infections or vaccines, resulting in enhanced responsiveness upon…”
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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens by Netea, Mihai G., Schlitzer, Andreas, Placek, Katarzyna, Joosten, Leo A.B., Schultze, Joachim L.

“…Immunological memory is an important evolutionary trait that improves host survival upon reinfection. Memory is a characteristic recognized within both the…”
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Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection by Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Domínguez-Andrés, Jorge, Curtis, Nigel, van Crevel, Reinout, van de Veerdonk, Frank L., Bonten, Marc

“…SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased…”
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Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship by Netea-Maier, Romana T., Smit, Johannes W.A., Netea, Mihai G.

“…In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building…”
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Trained Immunity: Reprogramming Innate Immunity in Health and Disease by Bekkering, Siroon, Domínguez-Andrés, Jorge, Joosten, Leo A.B, Riksen, Niels P, Netea, Mihai G

“…Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has…”
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Blocking IL-1 to prevent respiratory failure in COVID-19 by van de Veerdonk, Frank L, Netea, Mihai G

“…COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it…”
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The Intersection of Epigenetics and Metabolism in Trained Immunity by Fanucchi, Stephanie, Domínguez-Andrés, Jorge, Joosten, Leo A.B., Netea, Mihai G., Mhlanga, Musa M.

“…The last few years have witnessed an increasing body of evidence that challenges the traditional view that immunological memory is an exclusive trait of the…”
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IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections by Slaats, Jeroen, Ten Oever, Jaap, van de Veerdonk, Frank L, Netea, Mihai G

“…The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate…”
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Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities by Li, Xiaofei, Wang, Hui, Yu, Xiang, Saha, Gundappa, Kalafati, Lydia, Ioannidis, Charalampos, Mitroulis, Ioannis, Netea, Mihai G., Chavakis, Triantafyllos, Hajishengallis, George

“…Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and…”
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Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses by Boutens, Lily, Hooiveld, Guido J., Dhingra, Sourabh, Cramer, Robert A., Netea, Mihai G., Stienstra, Rinke

“…Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory…”
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Impact of Historic Migrations and Evolutionary Processes on Human Immunity by Domínguez-Andrés, Jorge, Netea, Mihai G.

“…The evolution of mankind has constantly been influenced by the pathogens encountered. The various populations of modern humans that ventured out of Africa…”
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Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly by Giamarellos-Bourboulis, Evangelos J., Tsilika, Maria, Moorlag, Simone, Antonakos, Nikolaos, Kotsaki, Antigone, Domínguez-Andrés, Jorge, Kyriazopoulou, Evdoxia, Gkavogianni, Theologia, Adami, Maria-Evangelia, Damoraki, Georgia, Koufargyris, Panagiotis, Karageorgos, Athanassios, Bolanou, Amalia, Koenen, Hans, van Crevel, Reinout, Droggiti, Dionyssia-Irene, Renieris, George, Papadopoulos, Antonios, Netea, Mihai G.

“…BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE…”
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BCG-induced protection: Effects on innate immune memory by Netea, Mihai G, van Crevel, Reinout

“…Highlights • BCG vaccine is the only vaccine proved to be effective against tuberculosis. • BCG also exerts non-specific protective effects against…”
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Trained immunity: A program of innate immune memory in health and disease by Netea, Mihai G., Joosten, Leo A. B., Latz, Eicke, Mills, Kingston H. G., Natoli, Gioacchino, Stunnenberg, Hendrik G., O'Neill, Luke A. J., Xavier, Ramnik J.

“…The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in…”
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Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases by Sanna, Serena, van Zuydam, Natalie R., Mahajan, Anubha, Kurilshikov, Alexander, Vich Vila, Arnau, Võsa, Urmo, Mujagic, Zlatan, Masclee, Ad A. M., Jonkers, Daisy M. A. E., Oosting, Marije, Joosten, Leo A. B., Netea, Mihai G., Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Wijmenga, Cisca, McCarthy, Mark I.

“…Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2…”
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Induction of innate immune memory: the role of cellular metabolism by Domínguez-Andrés, Jorge, Joosten, Leo AB, Netea, Mihai G

“…[Display omitted] •Cells from the innate immune system can undergo functional reprogramming.•Trained immunity involves rewiring the intracellular immune…”
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Trained immunity: a memory for innate host defense by Netea, Mihai G, Quintin, Jessica, van der Meer, Jos W M

“…Immune responses in vertebrates are classically divided into innate and adaptive, with only the latter being able to build up immunological memory. However,…”
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Gut microbiome in ADHD and its relation to neural reward anticipation by Aarts, Esther, Ederveen, Thomas H A, Naaijen, Jilly, Zwiers, Marcel P, Boekhorst, Jos, Timmerman, Harro M, Smeekens, Sanne P, Netea, Mihai G, Buitelaar, Jan K, Franke, Barbara, van Hijum, Sacha A F T, Arias Vasquez, Alejandro

“…Microorganisms in the human intestine (i.e. the gut microbiome) have an increasingly recognized impact on human health, including brain functioning…”
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