Search Results - "Nestal de Moraes, Gabriela"

FOXM1: A key oncofoetal transcription factor in health and disease by Bella, Laura, Zona, Stefania, Nestal de Moraes, Gabriela, Lam, Eric W.-F

“…Abstract Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which orchestrates complex temporal and spatial gene expression throughout…”
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FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance by Nestal de Moraes, Gabriela, Delbue, Deborah, Silva, Karina L., Robaina, Marcela Cristina, Khongkow, Pasarat, Gomes, Ana R., Zona, Stefania, Crocamo, Susanne, Mencalha, André Luiz, Magalhães, Lídia M., Lam, Eric W.-F., Maia, Raquel C.

“…Drug resistance is a major hurdle for successful treatment of breast cancer, the leading cause of deaths in women throughout the world. The FOXM1 transcription…”
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Ectonucleotidase activity driven by acid ectophosphatase in luminal A MCF‐7 breast cancer cells by Lacerda‐Abreu, Marco Antonio, Mendonça, Bruna dos Santos, Nestal de Moraes, Gabriela, Meyer‐Fernandes, José Roberto

“…Ectophosphatases catalyse the hydrolysis of phosphorylated molecules, such as phospho‐amino acids, in the extracellular environment. Nevertheless, the…”
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Primary diffuse large B‐cell lymphoma of the head and neck in a Brazilian single‐center study by Bernardo, Paula Sabbo, Hancio, Thaís, Vasconcelos, Flavia da Cunha, Nestal de Moraes, Gabriela, Sá Bigni, Ricardo, Wernersbach Pinto, Luciana, Thuler, Luiz Claudio Santos, Maia, Raquel Ciuvalschi

“…Objectives Lymphomas represent around 10% of head and neck neoplasms, among which the diffuse large B‐cell lymphoma (DLBCL) is the most common histologic…”
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Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance by Nestal de Moraes, Gabriela, Bella, Laura, Zona, Stefania, Burton, Matthew J, Lam, Eric W-F

“…FOXO3a and FOXM1 are two forkhead transcription factors with antagonistic roles in cancer and DNA damage response. FOXO3a functions like a typical tumour…”
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FOXK2 Transcription Factor and Its Emerging Roles in Cancer by Nestal de Moraes, Gabriela, Carneiro, Luciana da Torre, Maia, Raquel Ciuvalschi, Lam, Eric Wing-Fai, Sharrocks, Andrew David

“…Forkhead box (FOX) transcription factors compose a large family of regulators of key biological processes within a cell. FOXK2 is a member of FOX family, whose…”
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Osteopontin‑c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity by Brum, Mariana Concentino Menezes, Dos Santos Guimaraes, Isabella, Ferreira, Luciana Bueno, Rangel, Leticia Batista Azevedo, Maia, Raquel Ciuvalschi, Nestal De Moraes, Gabriela, Gimba, Etel R P

“…Osteopontin (OPN) is upregulated in several types of tumor and has been associated with chemoresistance. However, the contribution of OPN splicing isoforms…”
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IKZF1 deletion and co‐occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia by Klumb, Claudete Esteves, Barbosa, Thayana da Conceição, Nestal de Moraes, Gabriela, Schramm, Marcia Trindade, Emerenciano, Mariana, Maia, Raquel Ciuvalschi

“…Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a…”
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Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review) by Brandão Da Silva Assis, Mariane, Nestal De Moraes, Gabriela, De Souza, Kátia Regina

“…The chemistry of pure cerium oxide (CeO ) nanoparticles has been widely studied since the 1970s, especially for chemical catalysis. CeO nanoparticles have been…”
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The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration by Lemos, Lauana Greicy Tonon, Longo, Gabriel Mello da Cunha, Mendonça, Bruna Dos Santos, Robaina, Marcela Cristina, Brum, Mariana Concentino Menezes, Cirilo, Caíque de Assis, Gimba, Etel Rodrigues Pereira, Costa, Paulo Roberto Ribeiro, Buarque, Camilla Djenne, Nestal de Moraes, Gabriela, Maia, Raquel Ciuvalschi

“…Drug resistance represents a major issue in treating breast cancer, despite the identification of novel therapeutic strategies, biomarkers, and subgroups. We…”
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XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells by Silva, Karina Lani, de Souza, Paloma Silva, Nestal de Moraes, Gabriela, Moellmann-Coelho, Arthur, Vasconcelos, Flavia da Cunha, Maia, Raquel Ciuvalschi

“…Abstract P-glycoprotein (Pgp) and XIAP co-expression has been discussed in the process of the acquisition of multidrug resistance (MDR) in cancer. Here, we…”
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FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance by Zona, Stefania, Bella, Laura, Burton, Matthew J., Nestal de Moraes, Gabriela, Lam, Eric W.-F.

“…FOXM1 is a transcription factor required for a wide spectrum of essential biological functions, including DNA damage repair, cell proliferation, cell cycle…”
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Unraveling survivin expression in chronic myeloid leukemia: Molecular interactions and clinical implications by Bernardo, Paula Sabbo, Lemos, Lauana Greicy Tonon, de Moraes, Gabriela Nestal, Maia, Raquel Ciuvalschi

“…Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the BCR-ABL oncoprotein, known to drive leukemogenesis by orchestrating…”
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Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review) by Gimba, Etel R P, Brum, Mariana C M, Nestal De Moraes, Gabriela

“…Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid…”
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Expression of nuclear XIAP associates with cell growth and drug resistance and confers poor prognosis in breast cancer by Delbue, Deborah, Mendonça, Bruna S., Robaina, Marcela C., Lemos, Lauana G.T., Lucena, Pedro I., Viola, João P.B., Magalhães, Lídia M., Crocamo, Susanne, Oliveira, Caio A.B., Teixeira, Felipe R., Maia, Raquel C., Nestal de Moraes, Gabriela

“…Evasion from apoptosis is one of the hallmarks of cancer. X-linked inhibitor of apoptosis protein (XIAP) is known to modulate apoptosis by inhibiting caspases…”
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The pterocarpanquinone LQB‑118 compound induces apoptosis of cytarabine‑resistant acute myeloid leukemia cells by Hancio, Thais, Mazzoccoli, Luciano, Guimaraes, Gustavo, Robaina, Marcela, Dos Santos Mendonqa, Bruna, de Moraes, Gabriela Nestal, da Costa Reis Monte-Mor, Barbara, Gutiyama, Luciana Mayumi, de Carvalho, Luize Otero, Netto, Chaquip Daher, Costa, Paulo R.R, de Faria, Fernanda Costas Casal, Maia, Raquel Ciuvalschi

“…Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates of myeloid…”
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[Corrigendum] The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors by Nestal De Moraes, Gabriela, Pereira Castro, Carolina, Salustiano, Eduardo, Dumas, Matheus, Costas, Fernanda, Wing-Fai Lam, Eric, Ribeiro Costa, Paulo, Maia, Raquel

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Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi–host cell interplay by Chain, Michelle de Oliveira, Paiva, Cefas Augusto de Medeiros, Maciel, Igor Oliveira, Neto, Alberto Nogueira, Castro, Vitória Fernandes de, Oliveira, Caroline Pacheco de, Mendonça, Bruna dos Santos, Nestal de Moraes, Gabriela, Reis, Sheila Albert dos, Carvalho, Marcelo Alex de, De-Melo, Luiz Dione Barbosa

“…Neglected tropical diseases, such as Chagas disease caused by the protozoa Trypanosoma cruzi, affect millions of people worldwide but lack effective treatments…”
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Doxorubicin induces cell death in breast cancer cells regardless of Survivin and XIAP expression levels by Nestal de Moraes, Gabriela, Vasconcelos, Flavia C., Delbue, Deborah, Mognol, Giuliana P., Sternberg, Cinthya, Viola, João P.B., Maia, Raquel C.

“…Breast cancer is the leading cause of deaths in women around the world. Resistance to therapy is the main cause of treatment failure and still little is known…”
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Immunodetection of caspase-3 by Western blot using glutaraldehyde by Nestal de Moraes, Gabriela, Carvalho, Érika, Maia, Raquel C., Sternberg, Cinthya

“…Cell death by apoptosis triggers the engagement of a conserved intracellular machinery of execution, involving mainly the activation of the caspase family of…”
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