Search Results - "Neschen, S."

Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice by Kiefer, F. W., Neschen, S., Pfau, B., Legerer, B., Neuhofer, A., Kahle, M., Hrabé de Angelis, M., Schlederer, M., Mair, M., Kenner, L., Plutzky, J., Zeyda, M., Stulnig, T. M.

“…Aims/hypothesis Obesity is strongly associated with the development of non-alcoholic fatty liver disease (NAFLD). The cytokine osteopontin (OPN) was recently…”
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Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure by Kluth, O., Mirhashemi, F., Scherneck, S., Kaiser, D., Kluge, R., Neschen, S., Joost, H.-G., Schürmann, A.

“…Aims/hypothesis Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a…”
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High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice by Kahle, M, Schäfer, A, Seelig, A, Schultheiß, J, Wu, M, Aichler, M, Leonhardt, J, Rathkolb, B, Rozman, J, Sarioglu, H, Hauck, S.M, Ueffing, M, Wolf, E, Kastenmueller, G, Adamski, J, Walch, A, Hrabé de Angelis, M, Neschen, S

“…Abstract Objective Excess lipid intake has been implicated in the pathophysiology of hepatosteatosis and hepatic insulin resistance. Lipids constitute…”
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Development of diabetes in obese, insulin-resistant mice : essential role of dietary carbohydrate in beta cell destruction by JÜRGENS, H. S, NESCHEN, S, TSCHÖP, M. H, SCHÜRMANN, A, JOOST, H.-G, ORTMANN, S, SCHERNECK, S, SCHMOLZ, K, SCHÜLER, G, SCHMIDT, S, BLÜHER, M, KLAUS, S, PEREZ-TILVE, D

“…The role of dietary carbohydrate in the pathogenesis of type 2 diabetes is still a subject of controversial debate. Here we analysed the effects of diets with…”
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Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes by Mirhashemi, F, Scherneck, S, Kluth, O, Kaiser, D, Vogel, H, Kluge, R, Schürmann, A, Neschen, S, Joost, H-G

“…Obesity and diabetes in mice can be modified by dietary variables. Here we systematically analysed the effect of the sucrose and fat content and of the fat…”
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Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism by Fürnsinn, C, Brunmair, B, Meyer, M, Neschen, S, Furtmüller, R, Roden, M, Kühnle, H F, Nowotny, P, Schneider, B, Waldhäusl, W

“…New thiazolidinediones BM13.1258 and BM15.2054 were studied with regard to their PPARγ‐agonistic activities and to their acute and chronic effects on glucose…”
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Acute non‐insulin‐like stimulation of rat muscle glucose metabolism by troglitazone in vitro by Fürnsinn, C., Neschen, S., Noe, C., Bisschop, M., Roden, M., Vogl, C., Schneider, B., Waldhäusl, W.

“…1 The direct short‐term effects of troglitazone on parameters of glucose metabolism were investigated in rat soleus muscle strips. 2 In muscle strips from…”
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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents by Morino, Katsutaro, Petersen, Kitt Falk, Dufour, Sylvie, Befroy, Douglas, Frattini, Jared, Shatzkes, Nadine, Neschen, Susanne, White, Morris F, Bilz, Stefan, Sono, Saki, Pypaert, Marc, Shulman, Gerald I

“…To further explore the nature of the mitochondrial dysfunction and insulin resistance that occur in the muscle of young, lean, normoglycemic, insulin-resistant…”
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Dual role of proapoptotic BAD in insulin secretion and beta cell survival by Danial, Nika N, Walensky, Loren D, Zhang, Chen-Yu, Choi, Cheol Soo, Fisher, Jill K, Molina, Anthony J A, Datta, Sandeep Robert, Pitter, Kenneth L, Bird, Gregory H, Wikstrom, Jakob D, Deeney, Jude T, Robertson, Kirsten, Morash, Joel, Kulkarni, Ameya, Neschen, Susanne, Kim, Sheene, Greenberg, Michael E, Corkey, Barbara E, Shirihai, Orian S, Shulman, Gerald I, Lowell, Bradford B, Korsmeyer, Stanley J

“…The proapoptotic BCL-2 family member BAD resides in a glucokinase-containing complex that regulates glucose-driven mitochondrial respiration. Here, we present…”
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Metabolic response to anisoosmolarity of rat skeletal muscle in vitro by Brunmair, B, Neschen, S, Gras, F, Roden, M, Nowotny, P, Waldhäusl, W, Fürnsinn, C

“…Isolated rat hepatocytes exhibit an insulin-like anabolic response to hypoosmotic incubation and a glucagon-like catabolic response to hyperosmotic incubation…”
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Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice by NESCHEN, Susanne, MORINO, Katsutaro, ROSSBACHER, Jörg C, PONGRATZ, Rebecca L, CLINE, Gary W, SONO, Saki, GILLUM, Matthew, SHULMAN, Gerald I

“…Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice Susanne Neschen 1 2 , Katsutaro Morino 1…”
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Disruption of Neural Signal Transducer and Activator of Transcription 3 Causes Obesity, Diabetes, Infertility, and Thermal Dysregulation by Gao, Qian, Wolfgang, Michael J., Neschen, Susanne, Morino, Katsutaro, Horvath, Tamas L., Shulman, Gerald I., Fu, Xin-Yuan, Friedman, Jeffrey M.

“…Signal transducer and activator of transcription (STAT)3 is widely expressed in the CNS during development and adulthood. STAT3 has been implicated in the…”
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Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice by Neschen, Susanne, Morino, Katsutaro, Hammond, Linda E., Zhang, Dongyan, Liu, Zhen-Xiang, Romanelli, Anthony J., Cline, Gary W., Pongratz, Rebecca L., Zhang, Xian-Man, Choi, Cheol S., Coleman, Rosalind A., Shulman, Gerald I.

“…In order to investigate the role of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1) in the pathogenesis of hepatic steatosis and…”
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UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats by Oberkofler, H., Neschen, S., Esterbauer, H., Waldhäusl, W., Patsch, W., Fürnsinn, C.

“…Uncoupling protein-3 (UCP3), a mitochondrial carrier protein predominantly expressed in muscle, has been suggested to release stored energy as heat. The…”
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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle by Kim, J K, Michael, M D, Previs, S F, Peroni, O D, Mauvais-Jarvis, F, Neschen, S, Kahn, B B, Kahn, C R, Shulman, G I

“…Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis of type 2 diabetes. Mice with muscle-specific inactivation of the…”
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Mitochondrial Glycerol-3-phosphate Acyltransferase-1 Is Essential in Liver for the Metabolism of Excess Acyl-CoAs by Hammond, Linda E, Neschen, Susanne, Romanelli, Anthony J, Cline, Gary W, Ilkayeva, Olga R, Shulman, Gerald I, Muoio, Deborah M, Coleman, Rosalind A

“…In vitro studies suggest that the mitochondrial glycerol-3-phosphate acyltransferase-1 (mtGPAT1) isoform catalyzes the initial and rate-controlling step in…”
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Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content by Neschen, Susanne, Moore, Irene, Regittnig, Werner, Yu, Chun Li, Wang, Yanlin, Pypaert, Marc, Petersen, Kitt Falk, Shulman, Gerald I

“…To examine the mechanism by which fish oil protects against fat-induced insulin resistance, we studied the effects of control, fish oil, and safflower oil…”
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The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models by Fuchs, H, Gailus-Durner, V, Adler, T, Pimentel, J A Aguilar, Becker, L, Bolle, I, Brielmeier, M, Calzada-Wack, J, Dalke, C, Ehrhardt, N, Fasnacht, N, Ferwagner, B, Frischmann, U, Hans, W, Hölter, S M, Hölzlwimmer, G, Horsch, M, Javaheri, A, Kallnik, M, Kling, E, Lengger, C, Maier, H, Mossbrugger, I, Mörth, C, Naton, B, Nöth, U, Pasche, B, Prehn, C, Przemeck, G, Puk, O, Racz, I, Rathkolb, B, Rozman, J, Schäble, K, Schreiner, R, Schrewe, A, Sina, C, Steinkamp, R, Thiele, F, Willershäuser, M, Zeh, R, Adamski, J, Busch, D H, Beckers, J, Behrendt, H, Daniel, H, Esposito, I, Favor, J, Graw, J, Heldmaier, G, Höfler, H, Ivandic, B, Katus, H, Klingenspor, M, Klopstock, T, Lengeling, A, Mempel, M, Müller, W, Neschen, S, Ollert, M, Quintanilla-Martinez, L, Rosenstiel, P, Schmidt, J, Schreiber, S, Schughart, K, Schulz, H, Wolf, E, Wurst, W, Zimmer, A, Hrabé de Angelis, M

“…The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is…”
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Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes in Gene Expression by BRUNMAIR, Barbara, GRAS, Florian, NESCHEN, Susanne, RODEN, Michael, WAGNER, Ludwig, WALDHÄUSL, Werner, FÜRNSINN, Clemens

“…Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes…”
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Troglitazone directly inhibits CO(2) production from glucose and palmitate in isolated rat skeletal muscle by Fürnsinn, C, Brunmair, B, Neschen, S, Roden, M, Waldhäusl, W

“…Troglitazone is a nuclear peroxisome proliferator-activated receptor-gamma agonist with insulin-sensitizing properties that has been introduced for the…”
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