Abstract 11054: A Novel Method of Conjunctival Vascular Screening to Detect Hemodynamic Alterations in Patients with Coronary Microvascular Disease
IntroductionA large proportion of patients with cardiovascular disease (CVD) remain asymptomatic until presentation with myocardial infarction. Conventional CV risk assessment can be augmented by investigations such as CT coronary artery calcium scoring; but are limited by cost, availability and exp...
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| Published in: | Circulation (New York, N.Y.) Vol. 144; no. Suppl_1; p. A11054 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Lippincott Williams & Wilkins
16-11-2021
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| Online Access: | Get full text |
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| Summary: | IntroductionA large proportion of patients with cardiovascular disease (CVD) remain asymptomatic until presentation with myocardial infarction. Conventional CV risk assessment can be augmented by investigations such as CT coronary artery calcium scoring; but are limited by cost, availability and exposure to ionizing radiation. This study utilizes the conjunctiva as a network of blood vessels that can be assessed non-invasively in order to compare hemodynamic parameters in patients with and without established coronary microvascular disease (MVD). MethodsWe assessed the conjunctival microcirculation of patients diagnosed with angina undergoing invasive coronary angiography and physiological evaluation of epicardial stenoses and MVD. All patients had haemodynamically insignificant epicardial disease (FFR ≥0.80). Conjunctival imaging was performed using an adapted iPhone 11pro and slit-lamp biomicroscope. We compared a cohort of patients with MVD (IMR ≥25); to a group of controls without MVD (IMR <25). ResultsA total of 54 patients were included (19 MVD and 35 controls). Table 1 demonstrates a comparison of baseline demographics and hemodynamics between the groups. A total of 866 conjunctival vessels were analysed (366 MVD and 500 controls) and the differences in microvascular parameters between groups determined (Table 2). Statistically significant differences were observed in axial velocity, cross sectional velocity and blood flow rate. ConclusionThis study demonstrates the ability to non-invasively detect abnormal microvascular function. The conjunctival microcirculation therefore has potential merit to complement conventional CV risk screening. |
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| ISSN: | 0009-7322 1524-4539 |
| DOI: | 10.1161/circ.144.suppl_1.11054 |